| Identification |
|---|
| BMDB Protein ID
| BMDBP00768 |
| Secondary Accession Numbers
| None |
| Name
| V-type proton ATPase subunit S1 |
| Synonyms
|
Not Available
|
| Gene Name
| ATP6AP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles. Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity. Involved in membrane trafficking and Ca(2+)-dependent membrane fusion. May play a role in the assembly of the V-type ATPase complex. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| X |
| Locus
| Not Available |
| SNPs
| ATP6AP1 |
| Gene Sequence
|
>1407 bp
ATGATGGCGGCGACCGCGGCGGCTCAGGTGCGGGCGGGGACGCGGTGGGCTCCAGCGCTC
TGCCGGATGCCATGGCTGCCGCTGATGCTGGTGGCGGCGGCAGCGGCGACGTCGGAGCAG
CAGGTGCCGCTGGTGCTGTGGTCGAGTGACCGAGGCCTGTGGGCTCCTGCGGCCGACACC
CACGAGGGCCATATCACCAGCGACATGCAGCTCTCCACCTACTTAGACCCCGCCCTGGAG
CTGGGCCCCCGAAATGTGCTGCTGTTCCTGCAGGACAAGCTGAGCATTGAGGACTTCACA
GCATATGGTGGCGTGTTTGGAAACAAGCAAGACAGCGCCTTTTCTAACCTGGAGAACGCC
CTGGACCTGGCCCCCTCCTCTCTGGTGCTTCCTGCTGTTGACTGGTACGCGATCAGCACT
CTGACCACTTACCTGCAGGAGAAGCTCGGGGCCAGCCCCCTGCACGTGGACTTGGCCACT
CTCCAGGAACTGAAGCTCAATGCCAGCATCCCGGCCTTGCTGCTCATCCGCCTGCCCTAC
ACAGCCAGCTCGGGTCTGATGGCACCGAAGGAAGTCCTCATGGGCAATGATGAGGTCATT
GGGCAGGTGCTGAGCACACTCAAGTCAGAAGACATCCCCTACACGGCGGCCCTCACGGCG
GTCCGCCCTTCTAGGGTGGCCCGCGATGTAGCCATGGTGACTGGGGGGCTGGGTCGCCAG
CTGTTGCAGAGAACGGTGGTGCCGCCTACAATGAATGTCCCCGTGAGTTACAATGACAGT
TACGACACCCGGATCCTCTTCTGGGCCCAAAACTTCTCAGTGGCCTACGGGGAGCACTGG
GAGGACCTGACCTCCCGCACCTTTGGGGTCCAGGACCTCAACCTGACTGGCTCCTTCTGG
AATGACACCGTTGCCAGGCTGGTGCTGACATATGACTCACTCTTTGGGACCATGGTGACA
TTCAAGTTCATTCTGGCTAACAGCTACTACTCAGTGTCTGCCCGGCACTGGTTTACCTTG
GAGAACCTGGAAATCCACAGCAATGGCTCCGTCGCCTACTTCAATGCCTCCCAGGTCACG
GGGCCCAGCATTTATTCCTTCCACTGTGAGCATGTCAGCAGTGAAAACGAGGATGGCAAC
CTCCTTGTGCCTGACACGCAGCCCTCTCTTTGGCAGATGACTTTTCGGGACTTCCAGATC
CAGGCCTTCAATGTGACAGACAAGAAGTTCTCCTATGCTAGCGACTGTGCAGGCTTCTTC
TCCCCGGGTATCTGGATGGGGTTGCTCACCTCCTTGTTCATGCTGTTCATCTTCACCTAC
GGCCTGCACATGATCCTCAGCCTCAAGACCATGGATCGCTTCGATGACCACAAGGGCCCC
ACCATCACTTTGACCCAGATCGTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 468 |
| Molecular Weight
| 51781.0 |
| Theoretical pI
| 4.78 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>V-type proton ATPase subunit S1
MMAATAAAQVRAGTRWAPALCRMPWLPLMLVAAAAATSEQQVPLVLWSSDRGLWAPAADT
HEGHITSDMQLSTYLDPALELGPRNVLLFLQDKLSIEDFTAYGGVFGNKQDSAFSNLENA
LDLAPSSLVLPAVDWYAISTLTTYLQEKLGASPLHVDLATLQELKLNASIPALLLIRLPY
TASSGLMAPKEVLMGNDEVIGQVLSTLKSEDIPYTAALTAVRPSRVARDVAMVTGGLGRQ
LLQRTVVPPTMNVPVSYNDSYDTRILFWAQNFSVAYGEHWEDLTSRTFGVQDLNLTGSFW
NDTVARLVLTYDSLFGTMVTFKFILANSYYSVSARHWFTLENLEIHSNGSVAYFNASQVT
GPSIYSFHCEHVSSENEDGNLLVPDTQPSLWQMTFRDFQIQAFNVTDKKFSYASDCAGFF
SPGIWMGLLTSLFMLFIFTYGLHMILSLKTMDRFDDHKGPTITLTQIV
|
| External Links |
|---|
| GenBank ID Protein
| AAA50752.1 |
| UniProtKB/Swiss-Prot ID
| P40682 |
| UniProtKB/Swiss-Prot Entry Name
| VAS1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U10039 |
| GeneCard ID
| ATP6AP1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
