1.0 2018-05-07 22:23:59 UTC 2020-05-20 21:52:38 UTC BMDBP00783 BMDBP03035 Enzyme PLA2G4A Involved in calcium ion binding Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (By similarity). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway. In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific. Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides. Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (By similarity). BMDB0000086 Glycerophosphocholine BMDB0007883 PC(14:0/20:4(5Z,8Z,11Z,14Z)) BMDB0002111 Water BMDB0001043 Arachidonic acid BMDB0010379 LysoPC(14:0) BMDB0008923 PE(16:0/16:0) BMDB0011503 LysoPE(16:0/0:0) 16 >2250 bp ATGTCATTTATAGATCCTTATCAACACATTATAGTGGAGCACCATTATTCCCACAAGTTC ACAGTAGTGGTGCTGCGTGCCACAAAAGTGACAAAGGGAACCTTTGGTGACATGCTTGAC ACTCCAGACCCCTATGTGGAACTTTTCATCTCTTCAACCCCCGACAGCAGGAAGAGAACA AGACACTTCAATAATGACATAAACCCTGTGTGGAATGAGACCTTTGAATTTATTTTGGAT CCTAATCAGGAAAATATTTTGGAGATCACTTTAATGGATGCCAATTATGTTATGGATGAA ACTCTTGGGACGACAACGTTTCCCATATCTTCTATGAAAGTGGGAGAGAAGAAACAGGTT CCTTTTATTTTCAATCAAGTCACTGAAATGATTCTGGAAATGTCTCTTGAAGTTTGTTCA TCCCCAGACCTCCGGTTTAGTATGGCTCTGTGTGACCAGGAGAAAGCTTTCAGACAACAG AGAAAGGAAAACATAAAGGAAAACATGAAGAAACTGCTGGGTCCAAAGAATAGTGAAGGC TTGCATTCTACACGTGATGTGCCTGTGGTGGCCATACTGGGCTCAGGTGGGGGATTTCGA GCCATGGTAGGATTCTCTGGTGTGATGAAGGCACTGTATGAGTCAGGGATTTTGGACTGT GCTACCTACATTGCTGGTCTTTCTGGATCCACATGGTATATGTCGACCTTATATTCTCAC CCTGATTTTCCAGAGAAAGGGCCAGAGGAGATTAACAAAGAGCTAATGAAAAATGTCAGC CACAACCCTCTTTTACTTCTCACACCACAGAAAATTAAAAGATATGTTGAGTCTTTATGG AGGAAAAAAAGTTCTGGACAACCTGTCACCTTTACTGATATCTTCGGGATGTTAATAGGA GAAACACTAATTCACAATAGAATGAACACTACCCTGAGTAGTTTGAAGGAAAAAGTCAAT ACTGGGCAGTGTCCTCTGCCGCTTTTCACCTGTCTCCATGTCAAACCCGATGTCTCAGAG CTGATGTTTGCAGATTGGGTTGAATTTAGTCCATTTGAGATTGGCATGGCTAAATATGGT ACTTTTATGGCGCCTGACTTATTTGGAAGCAAATTTTTTATGGGAACAGTTGTAAAGAAA TACGAAGAAAACCCCTTGCATTTCTTAATGGGTGTCTGGGGTAGTGCCTTTTCTATATTG TTCAACAGAGTCTTGGGAGTTTCTGGATCACAAAGTAAAGGTTCCACAATGGAAGAAGAA CTAGAAAATATTACAGCAAAGCATATTGTGAGTAATGATAGCTCAGACAGTGATGACGAA TCACAAGGACCCAAAGGCACTGAACATGAAGAAGCAGAAAGGGAATACCAAAATGATAAT CAAGCAAGTTGGGTCCAACGTATGCTCATGGCCTTGGTGAGTGACTCAGCTTTGTTCAAT ACCAGAGAAGGACGTGCCGGGAAGGTGCACAACTTCATGCTGGGCTTGAATCTCAATACA TCCTATCCAATGTCTCCTTTGAGAGACTTTACCATGCAAGAGTCCCTGGATGAAGACGAA TTGGATGCCGCTGTCGCAGATCCTGATGAATTTGAGCAGATATATGAGCCTTTGGATGTC AAAAGTAAAAAGATTCATGTGGTGGACAGTGGCCTCACATTTAACCTTCCATACCCTTTG ATCCTGAGACCTCAGAGGGGAGTTGATCTCATCATCTCCTTTGACTTTTCTGCAAGACCA GGTGACTCCAGTCCTCCGTTCAAGGAACTTCTACTTGCAGAAAAGTGGGCTAAAATGAAC AAGCTCCCCTTTCCAAAGATTGATCCTTACGTATTCGATCGAGAAGGACTGAAGGAATGC TATGTTTTTAAACCCAAGAATCCTGATGTCGAGAAAGATTGCCCGACTATCATTCACTTT GTTCTGGCCAACATCAACTTCAGAAAGTACAAGGCTCCAGGTGTTCCAAGAGAAACTAAT GAAGAGAAAGAAATAGCTGATTTTGATATTTTTGATGACCCTGAATCACCGTTTTCGACC TTCAACTTTCAATATCCCAATCAAGCATTTAAAAGGCTGCATGATCTCATGTACTTCAAT ACCCTGAACAACATTGATGTAATAAAGAATGCTATAGTCGAAAGCATCGAATATAGAAGG CAGAATCCGTCTCGTTGCTCTGTTTCCCTCAGTAGTGTTGAGGCAAGAAGATTCTTCAAC AAGGAGTTTCTAAGCAAACCCACAGCATAG 749 85350.0 5.18 12-31 67-88 100-117 137-158 170-198 204-222 None >Cytosolic phospholipase A2 MSFIDPYQHIIVEHHYSHKFTVVVLRATKVTKGTFGDMLDTPDPYVELFISSTPDSRKRT RHFNNDINPVWNETFEFILDPNQENILEITLMDANYVMDETLGTTTFPISSMKVGEKKQV PFIFNQVTEMILEMSLEVCSSPDLRFSMALCDQEKAFRQQRKENIKENMKKLLGPKNSEG LHSTRDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYIAGLSGSTWYMSTLYSH PDFPEKGPEEINKELMKNVSHNPLLLLTPQKIKRYVESLWRKKSSGQPVTFTDIFGMLIG ETLIHNRMNTTLSSLKEKVNTGQCPLPLFTCLHVKPDVSELMFADWVEFSPFEIGMAKYG TFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSKGSTMEEE LENITAKHIVSNDSSDSDDESQGPKGTEHEEAEREYQNDNQASWVQRMLMALVSDSALFN TREGRAGKVHNFMLGLNLNTSYPMSPLRDFTMQESLDEDELDAAVADPDEFEQIYEPLDV KSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMN KLPFPKIDPYVFDREGLKECYVFKPKNPDVEKDCPTIIHFVLANINFRKYKAPGVPRETN EEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMYFNTLNNIDVIKNAIVESIEYRR QNPSRCSVSLSSVEARRFFNKEFLSKPTA AAR17479.1 A4IFJ5 PA24A_BOVIN 1CJY AY363688 PLA2G4A