| Identification |
|---|
| BMDB Protein ID
| BMDBP00793 |
| Secondary Accession Numbers
| None |
| Name
| Alanine--glyoxylate aminotransferase 2, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| AGXT2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 20 |
| Locus
| Not Available |
| SNPs
| AGXT2 |
| Gene Sequence
|
>1545 bp
ATGACAGGAGCCTGGGGACATTTGCTGAGATCTTTGCACCTGAAAACCTTATCTCTCTGG
ATCCCCAAGACGTGCTTTTCCCTTAAGGCCCGTGCTTTCTGGACATCTGTGACCAGGTGC
GGTCTTCATACAAAGCCCAGCATGCCGCCATGTGACTTCACACCCGAAAGATACCAGTCC
CTGGCCTATAGCCGAGTCCTGGAGATCCATAAGCAACATCTCTCTCCTGTGCACACCGCC
TATTTCCCGGAGCCCCTGTTGCTCCACCAGGGACACGTGGAGTGGCTCTTTGATCATGAG
GGAAACAGATACCTGGATTTCTTTTCTGGGATTGTCACTGTCAGTGTTGGTCACTGCCAC
CCAAAAGTAAACGCAGCGGCGCAAAGGCAGCTGGGCCGCCTGTGGCATACAAGTTCTGTC
TTCTTCCACCCTCTGATCCACGAATATGCAGAGAAGCTTTCAGCACTTCTTCCTGAGCCT
TTGAAGGTCGTTTTCTTGGTGAACAGTGGTTCAGAAGCCAATGACCTAGCCATGCTGATG
GCCAGAGCACACTCAAACAGCACAGACATCATTTCTTTCAGAGGAGCCTACCATGGATGC
AGTCCTTACACACTTGGCTTGACAAATGTAGGCATCTATAAGATGGACCTCCCTCATGGG
ATGGGCTGCCAACCAACAATGTGCCCAGACATTTTCCATGGCCCTTGGGGAGGAAGCCAC
TGCCGAGATTCTCCAGTGCAAACAATTAGGAAGTGCAGCTGTGCGCCAGACTGCTGTCAA
GCTAAAGACCAGTATATTGAACAATTCAAAGATACTCTGAGCACTTCTGTGGCCAAATCA
ATTGCTGGATTTTTTGCAGAGCCAATTCAAGGGGTGAATGGCGTTGTTCAGTACCCGAAG
GGGTTTCTAAAGGAAGCCTTCGAGCTGGTGCGCGAGCGGGGAGGCGTGTGCATTGCAGAT
GAAGTGCAGACAGGATTTGGAAGGCTGGGCTCTCACTTCTGGGGCTTCCAAACACACGAT
GTCCTGCCAGATATTGTTACCATGGCTAAAGGGATTGGGAATGGCTTTCCCATGGCAGCA
GTCGTGACAACTCCAGATATTGCCAAGTCCTTAACCAAGCGCATGCTTCACTTCAATACC
TTTGGAGGGAACCCCATGGCCTGCGCCGTTGGTTCAGCAGTGCTTGAGGTGATTAAAGAA
GAAAATCTACAAGAAAATAGCCAAGAAGTTGGCACCTATATGTTGCTGAAGTTGGCTAAG
CTGCGGGATGAATTTGAAATTGTAGGAGATGTCCGAGGCAAAGGTCTCATGATAGGAATA
GAAATGGTGAAGGATAAGGAGAGCCGCCAGCCTCTTCCCCGTGAAGAAGTAAATCAAATC
CACCACGACTGCAAATGCATGGGGCTTCTGATTGGCAGAGGCGGCCTTTTCTCTCAGACT
TTCCGCATTGCGCCCTCAATGTGCATCACTAAACCAGAAGTTGATTTTGCAGTGGAAGTG
TTTCGCTCTGCCTTAATTCAACACATGGAGAGAAGAGCTAAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 514 |
| Molecular Weight
| 57226.0 |
| Theoretical pI
| 7.93 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Alanine--glyoxylate aminotransferase 2, mitochondrial
MTGAWGHLLRSLHLKTLSLWIPKTCFSLKARAFWTSVTRCGLHTKPSMPPCDFTPERYQS
LAYSRVLEIHKQHLSPVHTAYFPEPLLLHQGHVEWLFDHEGNRYLDFFSGIVTVSVGHCH
PKVNAAAQRQLGRLWHTSSVFFHPLIHEYAEKLSALLPEPLKVVFLVNSGSEANDLAMLM
ARAHSNSTDIISFRGAYHGCSPYTLGLTNVGIYKMDLPHGMGCQPTMCPDIFHGPWGGSH
CRDSPVQTIRKCSCAPDCCQAKDQYIEQFKDTLSTSVAKSIAGFFAEPIQGVNGVVQYPK
GFLKEAFELVRERGGVCIADEVQTGFGRLGSHFWGFQTHDVLPDIVTMAKGIGNGFPMAA
VVTTPDIAKSLTKRMLHFNTFGGNPMACAVGSAVLEVIKEENLQENSQEVGTYMLLKLAK
LRDEFEIVGDVRGKGLMIGIEMVKDKESRQPLPREEVNQIHHDCKCMGLLIGRGGLFSQT
FRIAPSMCITKPEVDFAVEVFRSALIQHMERRAK
|
| External Links |
|---|
| GenBank ID Protein
| AAI18403.1 |
| UniProtKB/Swiss-Prot ID
| Q17QF0 |
| UniProtKB/Swiss-Prot Entry Name
| AGT2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC118402 |
| GeneCard ID
| AGXT2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
