1.0 2018-05-07 22:24:03 UTC 2020-05-20 21:06:20 UTC BMDBP00799 Enzyme DPP4 Amino acid transport and metabolism Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. BMDB0000725 Hydroxyproline 2 >2298 bp ATGAAGACACCATGGAAGGTGCTCCTGGGATTGCTGGCGATCGCTGCGCTCGTCACCGTC ATCACTGTGCCCGTGGTTCTGCTGACCAAAGGCAATGATGCTTCAACTGATAGTCGCAGA ACCTACACTCTAGCCGATTATTTAAAAAATACTTTTAGAATGAAATTCTACAACTTGAGA TGGGTTTCAGATCATGAATATCTCTACAAACAAGAAAATAATATCTTGCTATTCAATGCT GAATATGGAAACAGCTCCATTTTCTTGGAGAACAGTACATTTGATGAATTTGGACATTCT ATAAATGATTATTCAGTTTCACCAGATAGACAATATATTCTCTTCGAATACAACTATGTG AAGCAATGGAGGCATTCCTACACAGCTTCCTATGACATTTATGACTTAAATAAAAGGCAG TTAATTACAGAAGAGAGAATCCCAAACAACACACAGTGGATCACATGGTCATCAGTGGGT CATAAATTGGCATACGTTTGGAACAATGATATTTATGTGAAAAATGAACCAAATTCTCCA AGTCAGAGGATCACATGGACTGGGAAAAAAGATGTAATCTATAATGGAATAACTGACTGG GTTTATGAAGAGGAAGTCTTCAGTGCTTATTCCGCTCTGTGGTGGTCTCCAAACAGCACT TTTTTAGCATATGCCCAATTTAACGACACAGAAGTCCCGCTGATTGAATACTCCTTCTAC TCCGATGAGTCACTGCAATATCCAAAGACCGTGAAGATTCCATATCCAAAGGCAGGAGCT GTGAATCCAACTATAAAGTTCTTTGTTGTAAATATCAGCAGTCTCAGCCCGAACATTAAT GCAACTTCCCAACAAATTGTTCCTCCTGGTTCTGTGTTAATAGGGGACCACTACTTGTGT GACGTGACATGGGTAACAGAAGAAAGGATTTCATTGCAGTGGCTCCGCAGGATTCAGAAC TATTCGATCATGGATATCTGTGACTATGACAGGTCCACGGGAAGATGGATTTCCTCAGTG GGACGGCAGCACATTGAAATAAGTACCACTGGCTGGGTTGGAAGATTTAGGCCTGCAGAG CCTCATTTTACCTCTGACGGGAATAGCTTCTACAAGATCATTAGCAACGAAGAGGGTTAC AAACACATTTGTCACTTCCAAACAGATAAGAGAAATTGCACATTTATTACAAAAGGAGCC TGGGAGGTCATTGGGATAGAAGCTCTTACCAGTGATTATCTATACTACATTAGCAATGAA TATAAAGGAATGCCAGGTGCAAGAAATCTTTATAAAATCCAACTTAATGACTACACAAAA GTGACGTGCCTCAGCTGTGAGCTGAATCCAGACAGGTGTCAGTATTACTCTGTATCGTTC AGTCAAGAGGCAAAGTACTATCAGCTGAGATGTTCCGGTCCCGGTCTGCCCCTCTATACT CTGCATAACAGCAACAATGATAAAGAACTGAGAGTCCTGGAAAACAATTCAGATTTGGAT CAAGTGCTGCAGGATGTCCAGATGCCCTCAAAGAAACTGGACTTCATTCATTTGCATGGG ACAAAATTTTGGTATCAGATGATCTTGCCTCCTCATTTTGATAAATCCAAGAAATATCCT CTGCTATTAGAAGTATATGCAGGCCCCTGTAGTCAAAAAGCGGATGCTATCTTCAGACTC AACTGGGCTACTTACCTTGCAAGCACAGAAAACATTATAGTAGCTAGCTTTGATGGCAGA GGAAGTGGTTACCAAGGAGATAAGATCATGCACGCAATCAACAGAAGATTGGGAACATTT GAAGTTGAAGATCAAATTGAAGCAACCAGACAGTTTTCAAAAATGGGATTTGTGGACGAC AAACGGATTGCAATTTGGGGCTGGTCATACGGAGGGTACGTAACCTCAATGGTGCTGGGA GCAGGAAGTGGTGTGTTCAAGTGTGGAATAGCCGTGGCGCCTGTATCCAAGTGGGAGTAC TATGACTCCGTGTACACAGAACGTTACATGGGTCTTCCAACTCCAGAAGACAACCTTGAC TCTTACAGGAATTCAACAGTCATGAGCAGAGCTGAAAATTTTAAACAAGTTGAGTACCTC CTTATTCATGGAACAGCAGATGATAACGTTCACTTTCAGCAGTCAGCTCAGATCTCCAAA GCCCTGGTGGATGCTGGAGTGGATTTCCAGTCAATGTGGTATACAGATGAAGACCACGGG ATCGCCAGCAGCACAGCACACCAACACATATACACCCACATGAGCCACTTCCTAAAACAA TGCTTCTCTCTACTTTAG 765 88369.0 6.32 7-29 None >Dipeptidyl peptidase 4 MKTPWKVLLGLLAIAALVTVITVPVVLLTKGNDASTDSRRTYTLADYLKNTFRMKFYNLR WVSDHEYLYKQENNILLFNAEYGNSSIFLENSTFDEFGHSINDYSVSPDRQYILFEYNYV KQWRHSYTASYDIYDLNKRQLITEERIPNNTQWITWSSVGHKLAYVWNNDIYVKNEPNSP SQRITWTGKKDVIYNGITDWVYEEEVFSAYSALWWSPNSTFLAYAQFNDTEVPLIEYSFY SDESLQYPKTVKIPYPKAGAVNPTIKFFVVNISSLSPNINATSQQIVPPGSVLIGDHYLC DVTWVTEERISLQWLRRIQNYSIMDICDYDRSTGRWISSVGRQHIEISTTGWVGRFRPAE PHFTSDGNSFYKIISNEEGYKHICHFQTDKRNCTFITKGAWEVIGIEALTSDYLYYISNE YKGMPGARNLYKIQLNDYTKVTCLSCELNPDRCQYYSVSFSQEAKYYQLRCSGPGLPLYT LHNSNNDKELRVLENNSDLDQVLQDVQMPSKKLDFIHLHGTKFWYQMILPPHFDKSKKYP LLLEVYAGPCSQKADAIFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTF EVEDQIEATRQFSKMGFVDDKRIAIWGWSYGGYVTSMVLGAGSGVFKCGIAVAPVSKWEY YDSVYTERYMGLPTPEDNLDSYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISK ALVDAGVDFQSMWYTDEDHGIASSTAHQHIYTHMSHFLKQCFSLL AAL67836.1 P81425 DPP4_BOVIN 1ORW AF461806 DPP4