| Identification |
|---|
| BMDB Protein ID
| BMDBP00824 |
| Secondary Accession Numbers
| None |
| Name
| Endonuclease 8-like 2 |
| Synonyms
|
Not Available
|
| Gene Name
| NEIL2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Replication, recombination and repair |
| Specific Function
| Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| Not Available |
| SNPs
| NEIL2 |
| Gene Sequence
|
>990 bp
ATGCCAGAGGGGCCGTCTGTGAGGAAGTTTCACCATCTGGTTTCTCCCTTTGTGGGGCAG
CAGGTGGTCAAGACAGGAGGCAGCAGCAAGAAGCTAAACCCCACAAGTTTCCAGTCCCTC
TGGCTGCAGGACAGCCAGGTCCATGGAAAGAAATTATTCCTTAGATTTGATCCAGATGAA
GAAGCTGTGTCCCTGGGCAATTCCCTACTGTCAGAGCCTCTACGAGAAGGAGAGCAGAAG
GACAAAGCCAGGCACCACCAAGAAGCCTCTGACCCGTCCTCCTGGTCCCCGGGAGGAGAC
AGTGCTGTCCCCAGTGGAGACGATGGTCTGCAGTGTTTGGGGGGAGACACCCCTGCAGGA
GGTGCTGAGAGATGGCTGCAGGTCAGCTTTGGTTTGTTTGGCAGCATTCGGGTGAACGAG
TTCTCCAGAGCGAAGAAGGCAAACAAGAGGGGTGACTGGAGGGACCCTGTACCCAGGCTG
GTCCTACATTTCAGCGGGAGTGGCTTCCTGGCCTTCTATAACTGTCAGATGACATGGCGC
TTCTCTTCCCCTGTGGTCAGTCCCGCCTCTGACATATTGTCAGAAAAGTTTCACCGAGGA
CAGGCCCTGGAGGCTCTGGGCCGGGAGCAGCCCATCTGCTATACGCTGTTGGACCAGCGA
TACTTCTCAGGCTTAGGGAACATCATTAAGAACGAGGCCCTGTTCAGAGCCGGGATCCAC
CCGCTTTCTCCAGGCTCCCTCCTGGGTCTTCCACGCCTCGAGGCCCTGGTGGACCATGTG
GTGGCCTTCAGTGCAGACTGGCTGCAGGGCAAATTCCAGGGCACACGGCAGCACACGCAG
ATCTACCAGAAGGAGCAGTGCCCTGCCGGGCACCAGGTGGTCAGAGAGTCCCTGGGGCCG
CCGGGGGGCTTCCAGAGGCTCACGTGGTGGTGCCCCCAGTGCCAGCCCAGGTTGTCAGCA
GATGAGCCCAAGCAGCTGCAGCCCTCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 329 |
| Molecular Weight
| 36392.0 |
| Theoretical pI
| 8.39 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Endonuclease VIII-like 2
MPEGPSVRKFHHLVSPFVGQQVVKTGGSSKKLNPTSFQSLWLQDSQVHGKKLFLRFDPDE
EAVSLGNSLLSEPLREGEQKDKARHHQEASDPSSWSPGGDSAVPSGDDGLQCLGGDTPAG
GAERWLQVSFGLFGSIRVNEFSRAKKANKRGDWRDPVPRLVLHFSGSGFLAFYNCQMTWR
FSSPVVSPASDILSEKFHRGQALEALGREQPICYTLLDQRYFSGLGNIIKNEALFRAGIH
PLSPGSLLGLPRLEALVDHVVAFSADWLQGKFQGTRQHTQIYQKEQCPAGHQVVRESLGP
PGGFQRLTWWCPQCQPRLSADEPKQLQPS
|
| External Links |
|---|
| GenBank ID Protein
| CAE48362.1 |
| UniProtKB/Swiss-Prot ID
| Q6IE77 |
| UniProtKB/Swiss-Prot Entry Name
| NEIL2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AC107065 |
| GeneCard ID
| NEIL2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
