1.0 2018-05-07 22:24:14 UTC 2020-05-20 21:06:01 UTC BMDBP00839 BMDBP03132 Enzyme ADA Nucleotide transport and metabolism Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (By similarity). Plays an important role in purine metabolism and in adenosine homeostasis (By similarity). Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events (By similarity). Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (By similarity). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (PubMed:23240012). Enhances CD4+ T-cell differentiation and proliferation (By similarity). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (By similarity). Stimulates plasminogen activation (By similarity). Plays a role in male fertility (By similarity). Plays a protective role in early postimplantation embryonic development (By similarity). BMDB0000050 Adenosine BMDB0000195 Inosine BMDB0002111 Water BMDB0000051 Ammonia BMDB0000101 Deoxyadenosine BMDB0000071 Deoxyinosine 13 >1092 bp ATGGCCCAGACGCCCGCCTTCAACAAGCCCAAAGTAGAACTGCATGTCCACCTGGATGGA GCCATCAAGCCCGAAACCATCTTATATTATGGCAGGAAGAGGGGCATCGCCCTCCCCGCC GACACGCCAGAGGAGCTACAGAACATCATCGGCATGGACAAGCCACTTAGCCTCCCAGAG TTCCTGGCCAAGTTCGACTACTACATGCCTGCCATTGCGGGCTGCCGGGAGGCTGTCAAA AGGATTGCCTACGAGTTTGTGGAGATGAAGGCCAAGGACGGCGTGGTGTATGTGGAGGTG CGCTACAGCCCACACCTGCTGGCCAACTCCAAGGTGGAGCCGATCCCCTGGAACCAGGCT GAAGGGGACCTCACCCCGGATGAGGTGGTGTCACTGGTGAACCAGGGCCTGCAGGAGGGG GAGCGGGACTTCGGCGTGAAGGTGCGGTCCATCCTGTGCTGCATGCGCCACCAGCCCAGC TGGTCCTCTGAGGTGGTGGAGCTGTGTAAGAAGTACCGAGAGCAGACCGTGGTGGCCATT GACCTGGCTGGAGATGAGACCATTGAAGGCAGCAGCCTCTTCCCTGGACATGTGAAGGCC TATGCGGAGGCCGTGAAGAGCGGCGTCCACCGCACGGTCCACGCCGGGGAAGTGGGCTCG GCCAATGTGGTGAAAGAGGCCGTGGACACACTCAAGACCGAGAGGCTGGGGCATGGCTAC CACACCCTGGAGGATGCCACCCTTTACAACAGGCTGCGGCAGGAAAACATGCACTTCGAG GTCTGCCCCTGGTCCAGCTACCTCACCGGCGCCTGGAAGCCCGACACGGAACACCCGGTT GTTCGGTTCAAAAACGACCAGGTTAACTACTCGCTCAACACGGATGACCCGCTCATCTTC AAGTCCACGCTGGACACGGATTACCAGATGACCAAGAATGAAATGGGCTTCACCGAAGAG GAGTTTAAGAGACTGAACATCAATGCGGCCAAGTCCAGTTTCCTCCCTGAAGATGAGAAG AAGGAGCTTCTTGATCTGCTCTATAAGGCCTACGGGATGCCCTCTCCGGCCTCTGCAGAG CAGTGTCTGTGA 363 40919.0 5.2 None >Adenosine deaminase MAQTPAFNKPKVELHVHLDGAIKPETILYYGRKRGIALPADTPEELQNIIGMDKPLSLPE FLAKFDYYMPAIAGCREAVKRIAYEFVEMKAKDGVVYVEVRYSPHLLANSKVEPIPWNQA EGDLTPDEVVSLVNQGLQEGERDFGVKVRSILCCMRHQPSWSSEVVELCKKYREQTVVAI DLAGDETIEGSSLFPGHVKAYAEAVKSGVHRTVHAGEVGSANVVKEAVDTLKTERLGHGY HTLEDATLYNRLRQENMHFEVCPWSSYLTGAWKPDTEHPVVRFKNDQVNYSLNTDDPLIF KSTLDTDYQMTKNEMGFTEEEFKRLNINAAKSSFLPEDEKKELLDLLYKAYGMPSPASAE QCL AAF91430.1 P56658 ADA_BOVIN 1KRM 1NDV 1NDW 1NDY 1NDZ 1O5R 1QXL 1UML 1V79 1V7A 1VFL 1W1I 1WXY 1WXZ 2BGN 2E1W 2Z7G 1KRM 1NDV 1NDW 1NDY 1NDZ 1O5R 1QXL 1VFL 1WXY AF280603 ADA