| Identification |
|---|
| BMDB Protein ID
| BMDBP00842 |
| Secondary Accession Numbers
| None |
| Name
| Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit |
| Synonyms
|
Not Available
|
| Gene Name
| DDOST |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in dolichyl-diphosphooligosaccharide-protein g |
| Specific Function
| Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (By similarity). |
| Pathways
|
- Protein glycosylation
- Protein modification
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| Not Available |
| SNPs
| DDOST |
| Gene Sequence
|
>1320 bp
ATGGCGACCCGCGCGGCCCGTGTGTGGTCCGGCTGGTGGCTGCTGCTGCTGCCTTTGCTT
GGCCTGGCCGGCGCCAGCGGTCCCCGCACCTTGGTACTGCTGGACAACCTCAACCTCCGG
GAGACGCATTCGCTTTTCTTCCGGAGCCTGAAGGATCGCGGCTTTGTACTCACATTCAAG
ACCGCAGATGACCCCAGCCTGTCCCTCATTAAGTACGGGGAGTTTCTTTATGACAATCTC
ATCATTTTCTCCCCTTCGGTAGAAGATTTTGGAGGAAATATCAACGTGGAGACCATCAGT
GCCTTTATCGACGGTGGAGGCAGTGTCCTGGTGGCTGCCGGCTCAGACATCGGCGACCCT
CTCCGAGAGCTGGGCAGTGAGTGTGGGATTGAGTTCGACGAGGAGAAAACAGCTGTCATC
GATCATCACAACTATGACGTCTCAGACCTTGGCCAGCACACGCTCATCGTGGCCGACACA
GAGAACCTGCTGAAGGCCCCCACCATCGTTGGGAAATCATCTCTGAATCCCATCCTCTTT
CGGGGCGTGGGTATGGTGGCCGACCCTGACAATCCTTTGGTGCTGGACATCCTGACGGGC
TCTTCCACCTCTTACTCCTTCTTCCCGGATAAACCCATCACCCAGTACCCGCACGCCGTG
GGGAAGAACACCCTTCTCATCGCGGGGCTGCAGGCCCGGAACAACGCCCGGGTCATCTTC
AGCGGCTCCCTTGACTTCTTCAGCGATGCCTTCTTCAACTCAGCGGTGCAGAAGGCTGCA
CCCGGCTCCCAGAGGTATTCCCAGACTGGCAACTACGAGCTGGCTGTGGCCCTTTCCCGC
TGGGTGTTCAAGGAGGAGGGGGTCCTCCGGGTGGGGCCCGTGTCCCATCATCGGGTGGGC
GAGACAGCGCCACCCAACGCCTACACCGTCACTGACCTAGTGGAATACAGCATCGTCATT
GAACAGCTCTCAGATGGAAAGTGGGTCCCATTTGATGGCGATGACATTCAGCTGGAGTTT
GTCCGCATCGATCCTTTTGTGAGGACCTTCTTGAAGAGGAAAGGTGGCAAATACAGCGTC
CAGTTCAAGTTGCCTGATGTGTACGGTGTGTTCCAGTTCAAAGTGGATTACAACCGGCTA
GGCTACACGCACCTGTACTCCTCCACTCAGGTGTCCGTGCGGCCGCTGCAGCACACGCAG
TACGAGCGCTTCATCCCCTCGGCCTACCCCTACTACGCCAGCGCCTTCTCCATGATGCTC
GGGCTCTTCATCTTCAGCGTCGTCTTCCTGCACATGAAGGAGAAGGAGAAGTCCGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 439 |
| Molecular Weight
| 48791.0 |
| Theoretical pI
| 5.61 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
MATRAARVWSGWWLLLLPLLGLAGASGPRTLVLLDNLNLRETHSLFFRSLKDRGFVLTFK
TADDPSLSLIKYGEFLYDNLIIFSPSVEDFGGNINVETISAFIDGGGSVLVAASSDIGDP
LRELGSECGIEFDEEKTAVIDHHNYDVSDLGQHTLIVADTENLLKAPTIVGKSSLNPILF
RGVGMVADPDNPLVLDILTGSSTSYSFFPDKPITQYPHAVGKNTLLIAGLQARNNARVIF
SGSLDFFSDAFFNSAVQKAAPGSQRYSQTGNYELAVALSRWVFKEEGVLRVGPVSHHRVG
ETAPPNAYTVTDLVEYSIVIEQLSDGKWVPFDGDDIQLEFVRIDPFVRTFLKRKGGKYSV
QFKLPDVYGVFQFKVDYNRLGYTHLYSSTQVSVRPLQHTQYERFIPSAYPYYASAFSMML
GLFIFSVVFLHMKEKEKSD
|
| External Links |
|---|
| GenBank ID Protein
| AAI49547.1 |
| UniProtKB/Swiss-Prot ID
| A6QPY0 |
| UniProtKB/Swiss-Prot Entry Name
| OST48_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC149546 |
| GeneCard ID
| DDOST |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
