| Identification |
|---|
| BMDB Protein ID
| BMDBP00847 |
| Secondary Accession Numbers
| None |
| Name
| Exostosin-1 |
| Synonyms
|
Not Available
|
| Gene Name
| EXT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in glucuronosyl-N-acetylglucosaminyl-proteogly |
| Specific Function
| Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). |
| Pathways
|
- Protein glycosylation
- Protein modification
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 14 |
| Locus
| Not Available |
| SNPs
| EXT1 |
| Gene Sequence
|
>2241 bp
ATGCAGGCCAAAAAACGCTATTTCATCCTGCTCTCAGCTGGCTCTTGTCTCGCCCTTTTG
TTTTATTTCGGAGGCTTGCAGTTTAGGGCATCGAGAAGCCACAGCCGGAGAGAAGAGCAC
AGCGGTCGGAATGGCTTGCACCATCCGAGTCCGGATCATTTCTGGCCCCGCTTCCCGGAC
GCTCTGCGCCCCTTCGTTCCCTGGGATCAATTGGAAAACGAGGATTCCAGTGTGCACGTT
TCGCCCCGGCAGAAGCGAGAGGCCAACTCGAGCATCTACAAAGGCAAGAAGTGCCGCATG
GAGTCCTGCTTCGATTTCACCCTTTGCAAGAAAAACGGCTTCAAAGTCTACGTCTACCCA
CAGCAAAAAGGGGAGAAAATTGCTGAAAGTTACCAAAACATTCTAGCGGCCATCGAGGGC
TCCAGGTTCTATACCTCGGACCCCAGCCAGGCGTGCCTCTTTGTCCTGAGTCTGGACACT
TTAGACCGAGACCAGTTGTCACCTCAGTATGTGCACAATTTGAGATCCAAAGTGCAGAGT
CTCCACTTGTGGAACAACGGTAGGAATCATTTAATTTTTAATTTATATTCCGGCACTTGG
CCTGACTACACCGAGGACGTGGGGTTTGACATCGGCCAGGCGATGCTGGCTAAAGCCAGC
ATCAGTACTGAAAACTTCCGACCCAACTTTGATGTTTCTATTCCCCTCTTTTCTAAGGAT
CATCCCAGGACAGGAGGGGAGAGGGGGTTTTTGAAGTTTAACACTATCCCTCCTCTCAGG
AAGTACATGCTGGTCTTCAAGGGGAAGAGGTACCTGACAGGGATAGGGTCAGACACCAGG
AATGCCTTATATCACGTCCATAACGGGGAGGACGTAGTGCTGCTCACCACCTGCAAGCAT
GGCAAAGACTGGCAGAAGCACAAGGATTCTCGCTGTGACCGGGACAACACCGAGTACGAG
AAATATGATTATCGGGAAATGCTGCACAATGCCACTTTCTGTCTGGTTCCTCGTGGTCGC
AGGCTTGGGTCCTTCAGGTTCCTGGAGGCTCTGCAGGCCGCCTGTGTCCCTGTGATGCTC
AGCAATGGATGGGAGTTGCCATTCTCTGAAGTGATTAATTGGAACCAAGCTGCCGTCATA
GGCGATGAGAGATTGTTATTACAGATTCCTTCTACAATCAGGTCTATTCATCAGGATAAA
ATCCTAGCACTTAGACAGCAGACACAATTCTTGTGGGAGGCTTATTTTTCTTCAGTTGAG
AAGATTGTATTAACTACACTAGAGATTATTCAGGACAGAATATTCAAGCACATATCACGC
AACAGTTTAATATGGAACAAACATCCTGGGGGATTGTTCGTCCTACCACAGTATTCATCT
TATCTGGGAGATTTCCCTTACTACTATGCTAATTTAGGTTTAAAGCCCCCCTCCAAATTC
ACTGCAGTCATCCACGCGGTGACCCCCCTGGTCTCTCAGTCCCAGCCAGTGTTGAAACTC
CTCGTGGCTGCAGCCAAGTCCCAGTACTGTGCCCAGATCATAGTTCTATGGAATTGTGAC
AAGCCCCTTCCAGCCAAACACCGCTGGCCTGCCACTTCTGTGCCTGTCATTGTCATTGAA
GGAGAAAGCAAGGTGATGAGCAGCCGTTTCCTGCCCTACGACAACATCATCACAGATGCT
GTGCTCAGCCTTGACGAGGACACCGTGCTTTCAACCACGGAGGTGGATTTTGCCTTCACC
GTGTGGCAGAGCTTCCCCGAGAGGATTGTGGGGTACCCCGCACGCAGCCATTTCTGGGAC
AACTCTAAGGAGCGGTGGGGCTACACGTCCAAGTGGACGAACGACTACTCCATGGTGTTG
ACGGGAGCTGCTATTTACCACAAATATTATCACTACCTTTACACCCATTACCTGCCAGCC
AGCCTGAAGAACATGGTGGACCAATTGGCCAACTGTGAGGACATACTCATGAATTTCCTG
GTGTCTGCTGTGACAAAATTGCCTCCAATCAAAGTGACCCAAAAGAAGCAGTATAAGGAG
ACAATGATGGGACAGACCTCTCGGGCTTCCCGCTGGGCTGACCCTGACCACTTTGCCCAG
CGACAAAGCTGCATGAATACGTTTGCCAGCTGGTTTGGCTACATGCCGCTGATCCACTCT
CAGATGAGGCTGGACCCCGTCCTCTTTAAAGACCAGGTCTCTATTCTGCGGAAGAAATAC
CGAGACATCGAGCGGCTTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 746 |
| Molecular Weight
| 86299.0 |
| Theoretical pI
| 9.34 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Exostosin-1
MQAKKRYFILLSAGSCLALLFYFGGLQFRASRSHSRREEHSGRNGLHHPSPDHFWPRFPD
ALRPFVPWDQLENEDSSVHVSPRQKREANSSIYKGKKCRMESCFDFTLCKKNGFKVYVYP
QQKGEKIAESYQNILAAIEGSRFYTSDPSQACLFVLSLDTLDRDQLSPQYVHNLRSKVQS
LHLWNNGRNHLIFNLYSGTWPDYTEDVGFDIGQAMLAKASISTENFRPNFDVSIPLFSKD
HPRTGGERGFLKFNTIPPLRKYMLVFKGKRYLTGIGSDTRNALYHVHNGEDVVLLTTCKH
GKDWQKHKDSRCDRDNTEYEKYDYREMLHNATFCLVPRGRRLGSFRFLEALQAACVPVML
SNGWELPFSEVINWNQAAVIGDERLLLQIPSTIRSIHQDKILALRQQTQFLWEAYFSSVE
KIVLTTLEIIQDRIFKHISRNSLIWNKHPGGLFVLPQYSSYLGDFPYYYANLGLKPPSKF
TAVIHAVTPLVSQSQPVLKLLVAAAKSQYCAQIIVLWNCDKPLPAKHRWPATSVPVIVIE
GESKVMSSRFLPYDNIITDAVLSLDEDTVLSTTEVDFAFTVWQSFPERIVGYPARSHFWD
NSKERWGYTSKWTNDYSMVLTGAAIYHKYYHYLYTHYLPASLKNMVDQLANCEDILMNFL
VSAVTKLPPIKVTQKKQYKETMMGQTSRASRWADPDHFAQRQSCMNTFASWFGYMPLIHS
QMRLDPVLFKDQVSILRKKYRDIERL
|
| External Links |
|---|
| GenBank ID Protein
| AAI40569.1 |
| UniProtKB/Swiss-Prot ID
| A5D7I4 |
| UniProtKB/Swiss-Prot Entry Name
| EXT1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC140568 |
| GeneCard ID
| EXT1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
