| Identification |
|---|
| BMDB Protein ID
| BMDBP00848 |
| Secondary Accession Numbers
| |
| Name
| UDP-glucose 6-dehydrogenase |
| Synonyms
|
Not Available
|
| Gene Name
| UGDH |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Cell wall/membrane/envelope biogenesis |
| Specific Function
| Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (By similarity). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). |
| Pathways
|
- Nucleotide-sugar biosynthesis
- UDP-alpha-D-glucuronate biosynthesis
- UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1
|
| Reactions
|
| Uridine diphosphate glucose + 2 NAD + Water → Uridine diphosphate glucuronic acid +2 NADH |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| Not Available |
| SNPs
| UGDH |
| Gene Sequence
|
>1485 bp
ATGTTTGAAATTAAGAAGATCTGCTGCATCGGTGCAGGCTATGTTGGTGGACCCACGTGT
AGTGTCATTGCTCACATGTGCCCCGAAATCAGGGTGACGGTTGTTGATATCAATGAATCA
AGAATCAATGCATGGAACTCTCCTACACTTCCTATTTATGAGCCAGGCCTAAAAGAAGTG
GTAGAATCCTGTCGAGGAAAAAATTTATTTTTTTCTACCAATATTGATGATGCCATTAAG
GAAGCTGATCTTGTGTTTATTTCTGTGAACACACCAACCAAAACCTATGGAATGGGAAAA
GGCCGTGCAGCAGATCTGAAGTATATTGAAGCTTGTGCTAGACGCATTGTGCAAAACTCA
CACGGGTACAAAATTGTGACTGAGAAAAGCACAGTCCCAGTGCGGGCAGCAGAAAGTATT
CGTCGAATATTTGATGCAAACACAAAACCCAACTTGAATTTACAGGTGCTGTCCAACCCT
GAGTTCTTGGCAGAAGGAACAGCCATCAAGGACCTGAAGAACCCAGACAGAGTACTGATT
GGAGGAGATGAAACCCCAGAGGGCCAGAGAGCTGTGCAAGCACTGTGTGCTGTGTATGAG
CACTGGGTTCCCAGAGAAAAGATCCTCACCACTAATACTTGGTCTTCAGAACTTTCCAAA
CTGACAGCAAATGCTTTTCTGGCCCAGAGAATCAGCAGCATTAATTCTATAAGTGCCCTC
TGTGAAGCAACAGGAGCTGATGTAGAAGAGGTGGCAACAGCCATTGGAATGGACCAGAGA
ATTGGAAATAAATTTCTGAAAGCCAGTGTTGGTTTTGGTGGGAGTTGCTTTCAAAAGGAT
GTTCTGAATTTGGTTTATCTCTGTGAGGCTCTAAATTTGCCTGAAGTAGCTCGTTATTGG
CAGCAGGTTATAGACATGAATGACTACCAGAGAAGGAGGTTTGCTTCCCGGATCATAGAC
AGTCTGTTTAATACAGTGACAGATAAGAAGATAGCTATTTTGGGGTTTGCTTTCAAAAAG
GACACTGGTGATACAAGAGAGTCATCTAGTATATATATTAGCAAATATTTGATGGATGAA
GGTGCACACCTCCATATATATGATCCGAAAGTACCAAGAGAACAGATAGTTGTGGATCTT
TCTCATCCAGGAGTTTCAAAGGACGACCAAGTGGCCCGGCTCGTGACCATTTCCAAAGAT
CCCTACGAAGCATGTGATGGTGCCCACGCCGTTGTGATTTGCACTGAGTGGGACATGTTT
AAGGAACTGGATTATGAACGCATTCATAAAAAAATGCTGAAACCAGCCTTTATCTTTGAC
GGACGACGTGTCCTGGACGGGCTCCACAATGAGCTACAAACCATTGGCTTCCAGATTGAA
ACAATTGGCAAGAAGGTGTCTTCAAAGAGAATTCCATATGCTCCTTCTGGTGAAATTCCA
AAGTTTAGTCTTCAGGATATGCCCAACAAGAAACCCAGAGTATAG
|
| Protein Properties |
|---|
| Number of Residues
| 494 |
| Molecular Weight
| 55136.0 |
| Theoretical pI
| 7.64 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>UDP-glucose 6-dehydrogenase
MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDINESRINAWNSPTLPIYEPGLKEV
VESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNS
HGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLI
GGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLTANAFLAQRISSINSISAL
CEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYW
QQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDE
GAHLHIYDPKVPREQIVVDLSHPGVSKDDQVARLVTISKDPYEACDGAHAVVICTEWDMF
KELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKKVSSKRIPYAPSGEIP
KFSLQDMPNKKPRV
|
| External Links |
|---|
| GenBank ID Protein
| AAC64183.1 |
| UniProtKB/Swiss-Prot ID
| P12378 |
| UniProtKB/Swiss-Prot Entry Name
| UGDH_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF095792 |
| GeneCard ID
| UGDH |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
