| Identification |
|---|
| BMDB Protein ID
| BMDBP00870 |
| Secondary Accession Numbers
| None |
| Name
| Very long-chain specific acyl-CoA dehydrogenase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| ACADVL |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, myristoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons. |
| Pathways
|
- Lipid metabolism
- Mitochondrial fatty acid beta-oxidation
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| ACADVL |
| Gene Sequence
|
>1968 bp
ATGCAGGCGGCGCGGATGACCGCGAGCTTGGGCCGTACTCTGCTGAGGCTGCGGGGCGTA
AGCTCGTGGCCCGGTGAGCTCTTGGGGCAGCCCCGGCCCGGCCCTGCCCCGCGACCCTAT
GCCAGTGGGGTCGCCCAGGCGGCTGTGGACCAGTCTGATTCCCAGCCTTCTGAGGCTTCG
ACCAGGGAAAAACGGGCCAACTCGGTATCTAAGTCCTTTGCTGTGGGCACGTTCAAGGGC
CAGCTCACCACCGATCAGGTGTTTCCATACCCGTCTGTGCTCAACGAGGACCAAACACAG
TTTCTCAAAGAGCTGGTGGGGCCCGTGACCCGATTCTTTGAGGAGGTGAACGATGCTGCC
AAGAATGACATGCTGGAAAGAGTGGAGGAGACCACCATGCAAGGTCTCAAGGAGTTGGGG
GCCTTTGGTCTGCAAGTACCCAATGAACTGGGTGGCGTGGGCCTCTGCAACACCCAGTAT
GCCCGATTGGTGGAGATCGTGGGCATGTATGACCTTGGCGTGGGCATCGTCCTGGGGGCC
CATCAGAGCATCGGTTTCAAAGGCATCCTGCTCTTCGGCACAAAGGCCCAGAAAGAAAAA
TATCTCCCCAAACTGGCATCTGGGGAGACTATAGCTGCTTTCTGTCTAACGGAGCCCTCC
AGTGGATCAGATGCAGCGTCCATCCGATCCTCAGCTGTGCCCAGCCCCTGTGGAAAATAC
TATACCCTCAACGGAAGCAAGATTTGGATCAGTAACGGGGGCCTGGCAGACATCTTCACG
GTCTTTGCCAAGACACCGGTTACAGACACAGCTACGGGCGCTGTGAAGGAGAAGATCACA
GCTTTTGTGGTGGAGAGGAGCTTTGGCGGCGTCACCCATGGGCCCCCTGAGAAGAAGATG
GGCATCAAAGCCTCAAACACAGCAGAGGTGTACTTTGACGGAGTACGGGTGCCAGCAGAG
AACGTACTGGGGGAGGTAGGGGGCGGCTTCAAGGTCGCCATGCATATTCTCAACAATGGA
AGGTTTGGCATGGCTGCAGCTCTGGCAGGCACCATGAAAGGCATCATTGCTAAGGCGGTG
GATCATGCTGCTAACCGTACCCAGTTTGGGGAGAAAATTCACAACTTTGGGCTGATCCAG
GAGAAGCTGGCCCGGATGGCTATGCTGCAGTATGTGACTGAGTCCATGGCGTACATGGTG
AGTGCCAACATGGACCAGGGATCCACGGACTTCCAGATAGAGGCCGCCATCAGCAAAATC
TTTGGCTCGGAGGCAGCCTGGAAAGTGACAGATGAGTGCATCCAAATCATGGGGGGCATG
GGCTTCATGAAGGAGCCTGGGGTAGAGCGTGTGCTCCGAGATCTTCGCATCTTCCGGATC
TTCGAGGGGACAAATGACATTCTCCGGCTGTTTGTGGCTCTGCAGGGCTGCATGGACAAA
GGAAAGGAACTCTCTGGGCTTGGCAATGCTCTAAAGAACCCTTTTGGGAATGCTGGCCTC
CTGCTAGGAGAGGCAGGCAAACAGCTGAGGCGGCGGGCAGGGCTGGGCAGTGGCCTGAGT
CTCAGTGGCATCGTCCACCAGGAACTGAGTCGGAGTGGTGAGCTGGCGGTGCAGGCTCTG
GAGCAGTTTGCCACCGTGGTGGAGGCCAAGCTGATAAAGCACAAGAAGGATATCATCAAT
GAACAGTTTCTGCTGCAGCGTCTGGCGGACAGTGCCATTGACCTCTATGCCATGGTGGTG
GTTCTGTCCAGGGCCTCAAGATCCCTGAGTGAAGGCCACCCCACAGCCCAGCATGAGAAA
ATGCTCTGTGACAGCTGGTGTATCGAGGCTGCAGCCCGGATCCGGGAGAACATGACTGCT
CTGCAGTCTGACCCCCAGCAGCAGGAGCTCTTTCGTAACTTCAAAAGCATCTCCAAGGCG
CTGGTGGAGCGGGGCGGCGTGGTCACCAGCAATCCCCTTGGTTTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 655 |
| Molecular Weight
| 70649.0 |
| Theoretical pI
| 8.78 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 55-75
- 78-98
- 199-219
- 228-247
|
| Protein Sequence
|
>Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
MRAARMAQSTGRQLLRLRGVSSWPGELLGQPRPGPARRPYASGVAQAAVDQSDSQPSEAS
TREKRANSVSKSFAVGTFKGQLTTDQVFPYPSVLNEDQTQFLKELVGPVTRFFEEVNDAA
KNDMLERVEETTMQGLKELGAFGLQVPNELGGVGLCNTQYARLVEIVGMYDLGVGIVLGA
HQSIGFKGILLFGTKAQKEKYLPKLASGETIAAFCLTEPSSGSDAASIRSSAVPSPCGKY
YTLNGSKIWISNGGLADIFTVFAKTPVTDTATGAVKEKITAFVVERSFGGVTHGPPEKKM
GIKASNTAEVYFDGVRVPAENVLGEVGGGFKVAMHILNNGRFGMAAALAGTMKGIIAKAV
DHAANRTQFGEKIHNFGLIQEKLARMAMLQYVTESMAYMVSANMDQGSTDFQIEAAISKI
FGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDLRIFRIFEGTNDILRLFVALQGCMDK
GKELSGLGNALKNPFGNAGLLLGEAGKQLRRRAGLGSGLSLSGIVHQELSRSGELAVQAL
EQFATVVEAKLIKHKKDIINEQFLLQRLADSAIDLYAMVVVLSRASRSLSEGHPTAQHEK
MLCDSWCIEAAARIRENMTALQSDPQQQELFRNFKSISKALVERGGVVTSNPLGF
|
| External Links |
|---|
| GenBank ID Protein
| AAA74051.1 |
| UniProtKB/Swiss-Prot ID
| P48818 |
| UniProtKB/Swiss-Prot Entry Name
| ACADV_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U30817 |
| GeneCard ID
| ACADVL |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
