| Identification |
|---|
| BMDB Protein ID
| BMDBP00878 |
| Secondary Accession Numbers
| None |
| Name
| NADPH:adrenodoxin oxidoreductase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| FDXR |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. |
| Pathways
|
- Cholesterol metabolism
- Steroid metabolism
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| FDXR |
| Gene Sequence
|
>1479 bp
GGGCTGGTTCCTCTTCCCAAGCATGGCTCCGCGCTGTTGGCGCTGGTGGCCCTGGTCGTC
TTGGACTCGGACTCGGCTGCCTCCTTCCAGGAGCATCCAGAACTTCGGCCAGCACTTCTC
CACACAGGAGCAGACCCCCCAGATCTGTGTGGTGGGCAGTGGCCCAGCTGGCTTTTACAC
GGCCCAGCACCTGCTAAAGCACCACTCCCGGGCCCACGTGGATATCTACGAGAAACAGCT
GGTGCCCTTCCGCCTGGTGCGCGTTTGGCTGGCGCTGACCACCCCGAGGTCAAGAATGTT
ACTCAACACCTTTACCCAGACGGCCCGCTCTGACCGCTGTGCCTTCTATGGCAACGTGGA
GGTGGGCAGGGATGTGACTGTGCAGGAGCTGCGGGTGTATCGCCTAACCGCCGTGGTGCT
GAGCTATGGGGCAGAGGACCATCAGGCCCTGGATATCCCTGGTGAGGAGTTGCCCGGCGT
GTTCTCGGCCCGGGCCTTTGTGGGCTGGTACAATGGGCTTCCTGAGAACCGGGAGCTGGC
CCCGGACCTGAGCTGTGACACAGCCGTGATTCTGGGGCAGGGGAATGTGGCTCTGGACGT
GGCCCGGATCCTGCTGACCCCCCCCGACCACCTGGAGAAAACGGACATCACTGAGGCCGC
CCTGGGAGCCCTGAGACAGAGTCGGGTGAAGACGGTGTGGATCGTGGGCCGACGTGGACC
CCTACAAGTGGCCTTCACCATAAAGGAGCTTCGGGAGATGATTCAGTTACCAGGAACTCG
GCCCATGTTGGATCCTGCGGATTTCTTGGGTCTCCAGGACAGAATCAGGGAGGCCGCTCG
CCCGAGGAAGCGGCTGATGGAACTGCTGCTTCGAACAGCCACGGAGAAGCCAGGGGTGGA
GGAGGCTGCCCGCCGGGCATCAGCCTCCCGTGCCTGGGGCCTCCGCTTCTTCCGAAGCCC
GCAGCAGGTCCTGCGCCTGCCAGATGGGCGGGCGCGACGATCCGCCTGGCAGTCACCAGA
ACTGGAGGGCATTGGAGAGGCACACCCGGGCAGTGCCCACTGGGGATGTGGAGGACCTCC
CTGTGGGCTGGTGCTGAGCAGCATTGGGTATAAGAGCCGCCCCATCGACCCCAGTGTGCC
CTTTGACCCCAAGCTCGGGGTTGTCCCCAATATGGAGGGCCGGGTTGTGGATGTGCCAGG
CCTCTACTGCAGCGGCTGGGTGAAGCGGGGACCCACAGGTGTCATCACCACCACCATGAC
CGACAGCTTCCTCACCGGCCAGATTCTGCTACAGGACCTGAAGGCCGGGCACCTGCCGTC
TGGCCCCAGGCCGGGCTCTGCATTCATCAAGGCCCTGCTGGACAGCCGAGGGGTCTGGCC
CGTGTCTTTCTCGGACTGGGAGAAACTGGATGCTGAGGAGGTGTCCCGGGGCCAGGCCTC
GGGGAAGCCCAGAGAGAAGCTGCTGGATCCTCAGGAGAT
|
| Protein Properties |
|---|
| Number of Residues
| 492 |
| Molecular Weight
| 54338.0 |
| Theoretical pI
| 8.58 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>NADPH:adrenodoxin oxidoreductase, mitochondrial
MAPRCWRWWPWSSWTRTRLPPSRSIQNFGQHFSTQEQTPQICVVGSGPAGFYTAQHLLKH
HSRAHVDIYEKQLVPFGLVRFGVAPDHPEVKNVINTFTQTARSDRCAFYGNVEVGRDVTV
QELQDAYHAVVLSYGAEDHQALDIPGEELPGVFSARAFVGWYNGLPENRELAPDLSCDTA
VILGQGNVALDVARILLTPPDHLEKTDITEAALGALRQSRVKTVWIVGRRGPLQVAFTIK
ELREMIQLPGTRPMLDPADFLGLQDRIKEAARPRKRLMELLLRTATEKPGVEEAARRASA
SRAWGLRFFRSPQQVLPSPDGRRAAGIRLAVTRLEGIGEATRAVPTGDVEDLPCGLVLSS
IGYKSRPIDPSVPFDPKLGVVPNMEGRVVDVPGLYCSGWVKRGPTGVITTTMTDSFLTGQ
ILLQDLKAGHLPSGPRPGSAFIKALLDSRGVWPVSFSDWEKLDAEEVSRGQASGKPREKL
LDPQEMLRLLGH
|
| External Links |
|---|
| GenBank ID Protein
| AAA30362.1 |
| UniProtKB/Swiss-Prot ID
| P08165 |
| UniProtKB/Swiss-Prot Entry Name
| ADRO_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| M17029 |
| GeneCard ID
| FDXR |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
