1.0 2018-05-07 22:24:32 UTC 2020-05-20 21:01:30 UTC BMDBP00904 Enzyme ERO1A Involved in electron carrier activity Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1 (By similarity). BMDB0001248 FAD 10 >1407 bp ATGGGCCGCCGCTGGGGCTTCCTGATCGGCTTCTTGGTCGCCGTGGGGTTGCTGGGCTTG GGCCACGGCGAGCAGCAGCCCTCAGAGACGGCGGCGCAGAGGTGCTTCTGCCAGGTTAGT GGTTACTTGGATGATTGTACCTGTGATGTTGAAACCATTGATAAATTTAATAACTACAGG CTTTTCCCAAGACTTCAAAAACTCCTGGAAAGTGACTACTTTAGATATTACAAGGTAAAC CTGAAAAGGCCATGTCCTTTCTGGAATGATATCAACCAGTGTGGAAGAAGGGATTGTGCC GTCAAGCCTTGTCACTCAGATGAAGTTCCTGATGGAATTAAGTCTGCAAGCTACAAGTAT TCTGAAGAAGCCAATAATCTCATTGAAGAATGTGAGCAAGCTGAACGACTTGGAGCTGTG GATGAATCTCTGAGTGAGGAAACACAGAAGGCTGTTCTTCAGTGGACCAAGCATGATGAT TCCTCAGACAACTTCTGTGAAGTTGATGATATACAGTCTCCTGATGCTGAGTATGTCGAT TTGCTCCTTAATCCCGAGCGCTACACGGGTTACAAAGGACCAGATGCTTGGAAGATATGG AATGTCATCTATGAAGAAAACTGTTTTAAGCCACAGACAATTAAAAGACCTTTAAATCCT TTGGCTTCTGGTCAAGGTAAAAGTGAAGAGAATACTTTTTACAGTTGGCTAGAAGGTCTC TGTGTAGAGAAAAGAGCATTCTACAGACTTATATCTGGCCTCCATGCAAGCATTAATGTG CATTTGAGTGCACGGTATCTTCTACAAGATACGTGGTTGGAAAAAAAATGGGGACACAAC ATTACAGAATTTCAACAGCGATTTGATGGAATATTAACTGAAGGAGAAGGTCCACGAAGG CTTAAGAACTTGTATTTTCTCTACTTAATAGAATTAAGGGCTTTGTCTAAAGTGGTTCCA TTCTTTGAGCGCCCAGATTTTCAACTCTTCACTGGAAATAAAGATCAGGATGCAGAAAAC AAAATGTTACTTCTGGAAATACTTCATGAAATCAAGTCATTTCCTTTGCATTTTGATGAG AATTCATTTTTTGCTGGGAATAAAAAAGAAGCAAACAAACTAAAGGAGGATTTTCGACTG CATTTTAGAAATATTTCAAGAATCATGGATTGTGTTGGTTGTTTGAAATGTCGACTGTGG GGAAAGCTTCAGACTCAGGGTTTGGGCACTGCTCTGAAGATCTTGTTTTCTGAGAAATTG ATTGCAAATATGCCAGAAAGTGGACCCAGTTATGAATTCCATCTAACCAGACAAGAAATA GTATCATTATTTAATGCATTTGGAAGAATTTCAACAAGTGTGAAAGAATTAGAAAACTTC AGGAACTTGTTACAAAATATTCATTAA 468 54297.0 6.0 1-23 >ERO1-like protein alpha MGRRWGFLIGFLVAVGLLGLGHGEQQPSETAAQRCFCQVSGYLDDCTCDVETIDKFNNYR LFPRLQKLLESDYFRYYKVNLKRPCPFWNDINQCGRRDCAVKPCHSDEVPDGIKSASYKY SEEANNLIEECEQAERLGAVDESLSEETQKAVLQWTKHDDSSDNFCEVDDIQSPDAEYVD LLLNPERYTGYKGPDAWKIWNVIYEENCFKPQTIKRPLNPLASGQGKSEENTFYSWLEGL CVEKRAFYRLISGLHASINVHLSARYLLQDTWLEKKWGHNITEFQQRFDGILTEGEGPRR LKNLYFLYLIELRALSKVVPFFERPDFQLFTGNKDQDAENKMLLLEILHEIKSFPLHFDE NSFFAGNKKEANKLKEDFRLHFRNISRIMDCVGCLKCRLWGKLQTQGLGTALKILFSEKL IANMPESGPSYEFHLTRQEIVSLFNAFGRISTSVKELENFRNLLQNIH AAI42180.1 A5PJN2 ERO1A_BOVIN BC142179 ERO1A