| Identification |
|---|
| BMDB Protein ID
| BMDBP00913 |
| Secondary Accession Numbers
| None |
| Name
| Kininogen-2 |
| Synonyms
|
Not Available
|
| Gene Name
| KNG2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Inorganic ion transport and metabolism |
| Specific Function
| (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| Not Available |
| SNPs
| KNG2 |
| Gene Sequence
|
>1860 bp
ATGAAATTAATCACCATCCTTTTCCTTTGTTCCAGGCTGCTACCAAGTTTAACCCAAGAG
TCCTCTCAAGAAATCGACTGCAATGACCAGGATGTATTTAAAGCTGTGGACGCTGCTCTG
ACAAAATACAACAGTGAAAACAAGAGTGGCAACCAGTTTGTATTGTACCGCATAACCGAG
GTCGCCAGAATGGATAATCCTGACACATTTTATTCCTTGAAGTACCAAATCAAGGAGGGC
GACTGTCCTTTTCAAAGTAACAAAACTTGGCAGGACTGTGACTACAAGGACTCTGCACAA
GCTGCCACAGGACAGTGCACAGCGACCGTGGCCAAGAGAGGGAATATGAAGTTCTCCGTG
GCTATCCAGACCTGCCTGATCACTCCAGCCGAGGGCCCCGTGGTGACAGCCCAGTATGAG
TGCCTTGGCTGTGTGCATCCCATATCTACCAAGAGCCCCGACTTGGAGCCTGTTCTGAGA
TATGCCATCCAATATTTTAACAACAACACCAGTCATTCCCACCTCTTTGATCTGAAAGAA
GTAAAAAGAGCCCAAAAACAGGTGGTGTCTGGATGGAACTATGAAGTTAATTACTCAATT
GCACAAACTAATTGTTCCAAGGAGGAATTTTCATTCTTAACTCCAGACTGCAAGTCCCTT
TCAAGTGGTGATACTGGTGAATGTACAGATAAAGCACATGTAGATGTCAAGCTAAGAATT
TCTTCCTTCTCGCAGAAATGTGACCTTTATCCAGGGGAGGATTTTTTACCCCCCATGGTT
TGTGTCGGCTGCCCCAAACCTATACCTGTTGACAGCCCAGACCTGGAGGAAGCTCTGAAC
CATTCCATCGCAAAGCTTAATGCAGAGCATGATGGAACCTTCTATTTCAAGATTGACACT
GTGAAAAAAGCAACAGTACAGGTGGTAGGTGGATTGAAGTATTCTATTGTGTTCATAGCA
AGGGAAACCACATGTTCTAAGGGAAGTAATGAAGAGCTGACCAAGAGTTGTGAGATCAAT
ATACATGGTCAAATTCTACACTGTGATGCTAATGTCTATGTGGTGCCTTGGGAGGAAAAA
GTTTACCCTACTGTCAACTGTCAACCACTTGGACAGACCTCACTCATGAAAAGGCCTCCG
GGTTTTTCACCTTTCCGATCAGTTCAAGTGATGAAAACTGAAGGAAGCACAACTGTAAGT
CTACCCCACTCTGCCATGTCACCTGTACAAGATGAAGAGCGGGATTCAGGAAAAGAACAA
GGACCCACTCATGGGCATGGCTGGGACCATGGAAAGCAAATAAAATTACATGGCCTTGGC
CTTGGCCATAAACATAAGCATGACCAAGGTCATGGGCACCATAGAAGTCATGGTCTTGGC
CATGGACATCAAAAGCAACATGGTCTTGGCCATGGACATAAGCATGGTCATGGCCACGGA
AAACATAAAAACAAAGGAAAAAACAATGGAAAGCATTATGATTGGAGGACACCCTATTTG
GCAAGTTCTTATGAAGATAGCACTACATCCTCTGCACAGACGCAAGAGAAGACAGAAGAG
ACAACACTCTCTTCCCTAGCCCAGCCAGGTGTAGCCATTACCTTTCCTGACTTTCAGGAC
TCAGATCTCATTGCAACTGTGATGCCTAATACACTACCACCTCACACAGAGAGTGATGAT
GACTGGATCCCTGACATCCAGACAGAGCCAAATAGCCTTGCATTTAAATTGATTTCAGAT
TTTCCAGAAACAACCTCCCCCAAATGTCCTAGTCGCCCCTGGAAGCCAGTTAATGGAGTG
AATCCAACTGTGGAAATGAAAGAGTCTCATGATTTTGATCTTGTTGATGCTCTTCTTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 619 |
| Molecular Weight
| 68710.0 |
| Theoretical pI
| 6.55 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Kininogen-2
MKLITILFLCSRLLPSLTQESSQEIDCNDQDVFKAVDAALTKYNSENKSGNQFVLYRITE
VARMDNPDTFYSLKYQIKEGDCPFQSNKTWQDCDYKDSAQAATGQCTATVAKRGNMKFSV
AIQTCLITPAEGPVVTAQYECLGCVHPISTKSPDLEPVLRYAIQYFNNNTSHSHLFDLKE
VKRAQKQVVSGWNYEVNYSIAQTNCSKEEFSFLTPDCKSLSSGDTGECTDKAHVDVKLRI
SSFSQKCDLYPGEDFLPPMVCVGCPKPIPVDSPDLEEALNHSIAKLNAEHDGTFYFKIDT
VKKATVQVVGGLKYSIVFIARETTCSKGSNEELTKSCEINIHGQILHCDANVYVVPWEEK
VYPTVNCQPLGQTSLMKRPPGFSPFRSVQVMKTEGSTTVSLPHSAMSPVQDEERDSGKEQ
GPTHGHGWDHGKQIKLHGLGLGHKHKHDQGHGHHRSHGLGHGHQKQHGLGHGHKHGHGHG
KHKNKGKNNGKHYDWRTPYLASSYEDSTTSSAQTQEKTEETTLSSLAQPGVAITFPDFQD
SDLIATVMPNTLPPHTESDDDWIPDIQTEPNSLAFKLISDFPETTSPKCPSRPWKPVNGV
NPTVEMKESHDFDLVDALL
|
| External Links |
|---|
| GenBank ID Protein
| CAA24736.1 |
| UniProtKB/Swiss-Prot ID
| P01045 |
| UniProtKB/Swiss-Prot Entry Name
| KNG2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| V01492 |
| GeneCard ID
| KNG2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
