| Identification |
|---|
| BMDB Protein ID
| BMDBP00936 |
| Secondary Accession Numbers
| |
| Name
| Aromatic-L-amino-acid decarboxylase |
| Synonyms
|
Not Available
|
| Gene Name
| DDC |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. |
| Pathways
|
- Catecholamine biosynthesis
- Dopamine biosynthesis
- Dopamine from L-tyrosine: step 2/2
|
| Reactions
|
| L-Tyrosine → Tyramine + Carbon dioxide |
details
|
| 5-Hydroxykynurenine → 5-Hydroxykynurenamine + Carbon dioxide |
details
|
| L-Tryptophan → Tryptamine + Carbon dioxide |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| Not Available |
| SNPs
| DDC |
| Gene Sequence
|
>1464 bp
ATGAATGCAAGCGAGTTCCGCAGGCGGGGGAAGGAGATGGTGGATTACGTGGCTGACTAC
TTGGAGGGCATTGAAGGGCGCCAGGTGTTCCCTGACGTGGATCCAGGCTACCTGCGCCCC
CTGATCCCCACCACCGCCCCGCAGGAGCCAGAGACATTTGAGGCCATCATCGAGGACATC
GAGAAGATCATCATGCCGGGGGTGACCCACTGGCACAGTCCCTACTTCTTCGCCTACTTC
CCCACGGCCAGTTCGTACCCGGCCATGCTCGCGGACATGCTGTGTGGGGCCATCGGCTGC
ATCGGCTTCTCCTGGGCTGCCAGCCCGGCGTGCACAGAGCTCGAGACGGTGATGATGGAC
TGGCTGGGGAAGATGCTGCAGCTGCCAGAGGCGTTTCTGGCTGGAGAAGCTGGAGAAGGC
GGCGGGGTGATCCAGGGAACTGCCAGTGAAGCTACCCTTGTGGCCCTGCTGGCCGCTCGG
ACCAAAGTGACCCGACACCTGCAGGCTCGTGCCCCAGAGCTGACGCAGGCTGCCATCATG
GAGAAGTTGGTGGCCTACGCATCTGACCAGGCACACTCCTCCGTGGAAAAAGCCGGCTTA
ATTGGCGGAGTGAGATTAAAAGCCATCCCTTCCGATGGCAAGTTTGCCATGCGAGCTTCG
CGCTGCAGGAGGCTGGAGAGAGACAAGGCAGCCGGCCTGATTCCTTCTTGCTTCGTGGTG
GCTACACTGGGGACCACGTCCTGCTGCTCCTTTGACAACCTCTTAGAAGTGGGGCCCATT
TGTCACAAGGAGGGCTTGTGGCTGCACGTGGACGCCGCCTACGCAGGCAGTGCCTTCATC
TGCCCTGAGTTCCGGCATCTTCTGAATGGCGTGGAGTTTGCAGATTCATTTAACTTTAAT
CCCCACAAATGGCTCTTGGTGAATTTTGACTGCTCTGCCATGTGGGTGAAAAAGAGGACA
GACCTGACCGGAGCCTTCAGGCTGGACCCAGTCTATCTGAGGCACAGCCACCAGGACTCA
GGGCTTATCACTGACTACAGGCACTGGCAGCTGCCACTGGGCCGGAGGTTCCGCTCTTTG
AAGATGTGGTTTGTTTTTAGGATGTACGGAGTCAAGGGACTGCAGGCCTATATCCGCAAG
CATGTCCAGCTGTCCCATGCATTCGAGGCATTGGTGCGCCAGGACACCCGCTTTGAAATC
TGTGCAGAAGTCATTCTGGGACTGGTCTGTTTCCGGCTAAAGGGTTCCAACAAACTGAAC
GAAGCTCTTCTGGAAAGCATAAACAGTGCCAAAAAAATCCACTTGGTCCCTTGTTCCCTG
AGAGACCGGTTCGTGCTGCGCTTCGCCATCTGCTCACGCACAGTGGAGCTGGCCCACGTA
CAGCTGGCCTGGGAGCACATCCAGGAGATGGCGGCCACAGTGTTAAGAGCACAGGGGGAG
GAAAAGGCAGAGATCAAAAATTGA
|
| Protein Properties |
|---|
| Number of Residues
| 487 |
| Molecular Weight
| 54294.0 |
| Theoretical pI
| 6.61 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Aromatic-L-amino-acid decarboxylase
MNASEFRRRGKEMVDYVADYLEGIEGRQVFPDVDPGYLRPLIPTTAPQEPETFEAIIEDI
EKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMD
WLGKMLQLPEAFLAGEAGEGGGVIQGTASEATLVALLAARTKVTRHLQAASPELMQAAIM
EKLVAYASDQAHSSVEKAGLIGGVRLKAIPSDGKFAMRASALQEALERDKAAGLIPFFVV
ATLGTTSCCSFDNLLEVGPICHEEGLWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN
PHKWLLVNFDCSAMWVKKRTDLTGAFRLDPVYLRHSHQDSGLITDYRHWQLPLGRRFRSL
KMWFVFRMYGVKGLQAYIRKHVQLSHAFEALVRQDTRFEICAEVILGLVCFRLKGSNKLN
EALLESINSAKKIHLVPCSLRDRFVLRFAICSRTVELAHVQLAWEHIQEMAATVLRAQGE
EKAEIKN
|
| External Links |
|---|
| GenBank ID Protein
| AAC41615.1 |
| UniProtKB/Swiss-Prot ID
| P27718 |
| UniProtKB/Swiss-Prot Entry Name
| DDC_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| M74029 |
| GeneCard ID
| DDC |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
