1.0 2018-05-07 22:24:50 UTC 2020-05-20 21:09:11 UTC BMDBP00969 Enzyme UBE2L3 Involved in ATP binding Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis. Protein modification Protein ubiquitination BMDB0000182 L-Lysine 17 >465 bp ATGGCGGCCAGCAGGAGGCTGATGAAGGAGCTTGAAGAAATCCGCAAGTGTGGGATGAAA AACTTCCGTAACATCCAGGTCGATGAAGCTAATTTGCTGACTTGGCAAGGGCTCATTGTT CCCGACAACCCTCCCTATGATAAGGGGGCCTTCAGAATCGAAATCAACTTTCCAGCAGAG TACCCCTTCAAACCACCGAAGATCACGTTCAAAACGAAGATCTACCACCCGAACATCGAC GAGAAGGGGCAGGTGTGTCTGCCTGTAATTAGTGCTGAAAACTGGAAGCCAGCAACCAAA ACCGACCAAGTCATCCAGTCCCTCATAGCACTGGTGAACGACCCCCAGCCGGAGCACCCG CTCCGGGCTGACCTAGCCGAAGAATACTCTAAGGACCGTAAAAAATTCTGTAAGAATGCT GAAGAATTTACAAAGAAATATGGGGAAAAGCGACCTGTGGACTAA 154 17862.0 8.79 None >Ubiquitin-conjugating enzyme E2 L3 MAASRRLMKELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPDNPPYDKGAFRIEINFPAE YPFKPPKITFKTKIYHPNIDEKGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHP LRADLAEEYSKDRKKFCKNAEEFTKKYGEKRPVD AAI05165.1 Q3MHP1 UB2L3_BOVIN 1FBV BC105164 UBE2L3