| Identification |
|---|
| BMDB Protein ID
| BMDBP00972 |
| Secondary Accession Numbers
| None |
| Name
| NEDD8-conjugating enzyme Ubc12 |
| Synonyms
|
Not Available
|
| Gene Name
| UBE2M |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation (By similarity). |
| Pathways
|
- Protein modification
- Protein neddylation
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| Not Available |
| SNPs
| UBE2M |
| Gene Sequence
|
>552 bp
ATGATCAAGCTGTTCTCGCTGAAGCAGCAGAAGAAGGAGGAGGAGTCGGCGGGCGGCACC
AAGGGCAGCAGCAAGAAGGCGTCGGCGGCGCAGCTGCGGATCCAGAAGGACATAAACGAG
CTGAATCTGCCCAAGACGTGTGACATCAGTTTCTCAGATCCAGACGACCTCCTCAACTTC
AAGCTGGTTATCTGTCCTGATGAGGGCTTCTACAAGAGCGGGAAGTTTGTGTTCAGTTTT
AAGGTGGGCCAGGGTTACCCGCATGACCCCCCCAAGGTGAAGTGTGAGACGATGGTTTAT
CACCCCAACATTGACCTCGAGGGCAACGTCTGCCTCAACATCCTCAGAGAGGACTGGAAG
CCAGTCCTTACGATAAACTCCATAATTTATGGCTTGCAGTATCTCTTCTTGGAGCCCAAC
CCTGAAGACCCACTGAACAAGGAAGCCGCCGAGGTCCTGCAGAACAACCGGAGGCTGTTT
GAGCAGAATGTCCAGCGCTCCATGCGGGGTGGCTATATCGGCTCCACTTACTTCGAGCGC
TGCCTGAAATAG
|
| Protein Properties |
|---|
| Number of Residues
| 183 |
| Molecular Weight
| 20900.0 |
| Theoretical pI
| 7.84 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>NEDD8-conjugating enzyme Ubc12
MIKLFSLKQQKKEEESAGGTKGSSKKASAAQLRIQKDINELNLPKTCDISFSDPDDLLNF
KLVICPDEGFYKSGKFVFSFKVGQGYPHDPPKVKCETMVYHPNIDLEGNVCLNILREDWK
PVLTINSIIYGLQYLFLEPNPEDPLNKEAAEVLQNNRRLFEQNVQRSMRGGYIGSTYFER
CLK
|
| External Links |
|---|
| GenBank ID Protein
| AAI33502.1 |
| UniProtKB/Swiss-Prot ID
| A3KN22 |
| UniProtKB/Swiss-Prot Entry Name
| UBC12_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC133501 |
| GeneCard ID
| UBE2M |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
