1.0 2018-05-07 22:24:52 UTC 2020-05-20 21:52:38 UTC BMDBP00975 Enzyme UBE2C Involved in ATP binding Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Protein modification Protein ubiquitination BMDB0000182 L-Lysine 13 >540 bp ATGGCTTCCCAGAACCGCGACCCAGTCGCCGCCAGCGTCGCCGCCGCCCGTAAAGGAGCC GAGCCCAGCGGGGGTGCTGCCCGGGGCCCTGTGGGCAAGAGGCTACAACAGGAGCTGATG ACTCTCATGATGTCTGGCGATAAAGGAATTTCTGCCTTCCCTGAATCCGACAACCTCTTC AAATGGGTGGGGACCATCCATGGAGCCGCTGGCACAGTATATGAAGACCTGAGGTATAAA CTGTCCCTGGAGTTCCCCAGTGGCTACCCTTACAACGCGCCCACGGTGAAGTTCCTCACA CCCTGCTACCATCCCAATGTGGACACCCAGGGTAACATCTGTCTGGACATCCTGAAAGAC AAGTGGTCCGCCCTGTATGACGTCAGGACCATCCTGCTCTCCATCCAGAGTCTGCTCGGA GAGCCCAACATTGATAGCCCTTTGAACACACATGCTGCCGAGCTCTGGAAAAACCCCACA GCCTTTAAGAAGTACCTGCAAGAAACCTACTCAAAGCAGGTCTCCAGCCAAGACCCCTGA 179 19608.0 7.5 156-176 180-200 None >Ubiquitin-conjugating enzyme E2 C MASQNRDPVAASVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNLF KWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKD KWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVSSQDP AAI08196.1 Q32PA5 UBE2C_BOVIN 1I7K BC108195 UBE2C