1.0 2018-05-07 22:24:52 UTC 2020-05-20 21:07:28 UTC BMDBP00978 Enzyme UBE2D2 Involved in ATP binding Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3. P53 Signaling Pathway SMP0100482 Protein modification Protein ubiquitination BMDB0000182 L-Lysine 7 >444 bp ATGGCTCTGAAGAGAATCCATAAGGAATTGAATGACCTGGCACGGGACCCCCCAGCACAG TGTTCAGCAGGTCCCGTTGGAGATGATATGTTCCATTGGCAAGCTACAATAATGGGGCCA AATGACAGTCCCTATCAGGGTGGAGTATTTTTCTTGACAATTCATTTCCCAACAGATTAC CCCTTCAAACCACCTAAGGTTGCATTTACAACAAGAATTTATCATCCAAATATTAACAGT AATGGCAGCATTTGTCTTGATATTCTACGGTCACAGTGGTCTCCAGCACTAACTATTTCA AAAGTACTTTTGTCCATCTGTTCTCTGTTGTGTGATCCCAATCCAGATGATCCTTTAGTG CCTGAGATTGCTCGGATCTACAAAACAGATAGAGAAAAGTACAACAGAATAGCTCGGGAA TGGACTCAGAAGTATGCGATGTAA 147 16735.0 7.96 None >Ubiquitin-conjugating enzyme E2 D2 MALKRIHKELNDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDY PFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLV PEIARIYKTDREKYNRIAREWTQKYAM AAI14655.1 Q1RMX2 UB2D2_BOVIN 1UR6 BC114654 UBE2D2