1.0 2018-05-07 22:24:54 UTC 2020-05-20 21:08:55 UTC BMDBP00983 Enzyme UBE2T Involved in ATP binding Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Protein modification Protein ubiquitination BMDB0000182 L-Lysine >588 bp ATGCAGAGAACATCGCGTCTGAAGCGAGAGCTGAGCCTGCTGGCCGCGGAGCCGCCCCCG GGCATCACGTGCTGGCAGGATGGGGATCGGATGGAAGACCTGCGAGCGCAGATTCTAGGT GGAGCCAACACACCTTATGAAAAAGGTGTTTTCAAGCTGGAAGTTCACATTCCAGAGAGG TACCCATTTGAACCTCCTCAGATCCGATTTCTGACTCCCATCTATCACCCCAACATCGAC TCTGCGGGACGGATTTGTCTAGATGTTCTCAAGTTGCCACCAAAAGGTGCCTGGAGACCA TCCCTCAACATCGCAACCCTGCTGACTTGCATTCAGCAGCTCATGGCCGAGCCCAACCCG GACGACCCGCTCATGGCTGACATCTCCTCAGAGTTTAAATACAACAAGCCAGTCTTCTTC AAGAACGCCAGGCAGTGGACAGAGAAGCACGCACGGCAGAAGACAGACGAGGAAGGGATG CCTGGCAGCCTCCCCGAGGTGGGCGGCTCAGAGGGACCCAGCGCCGCACAGAAGAGGAAA GCTGGGCAGCTGAGCAGCGGTGGAAAGAGGTTTTGCCCTGACGTTTAG 195 21765.0 8.32 None >Ubiquitin-conjugating enzyme E2 T MQRTSRLKRELSLLAAEPPPGITCWQDGDRMEDLRAQILGGANTPYEKGVFKLEVHIPER YPFEPPQIRFLTPIYHPNIDSAGRICLDVLKLPPKGAWRPSLNIATLLTCIQQLMAEPNP DDPLMADISSEFKYNKPVFFKNARQWTEKHARQKTDEEGMPGSLPEVGGSEGPSAAQKRK AGQLSSGGKRFCPDV AAI09638.1 Q32LD2 UBE2T_BOVIN DAAA02043707 UBE2T