| Identification |
|---|
| BMDB Protein ID
| BMDBP00984 |
| Secondary Accession Numbers
| None |
| Name
| Ubiquitin-conjugating enzyme E2 K |
| Synonyms
|
Not Available
|
| Gene Name
| UBE2K |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53 (By similarity). Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. |
| Pathways
|
- Protein modification
- Protein ubiquitination
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| Not Available |
| SNPs
| UBE2K |
| Gene Sequence
|
>603 bp
ATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAG
GAGACGACGAAAAATCAAATTAAAGTAGATCTTGTAGATGAGAATTTTACAGAATTAAGA
GGAGAAATAGCAGGACCTCCAGACACACCATATGAAGGAGGAAGATATCAACTAGAGATT
AAAATACCAGAAACATATCCATTTAATCCCCCTAAGGTCCGGTTTATCACTAAAATATGG
CATCCTAATATTAGTTCCGTCACAGGGGCTATTTGTTTGGATATCCTGAAAGATCAATGG
GCAGCAGCAATGACTCTGCGCACGGTATTGTTGTCATTACAAGCTCTGCTGGCAGCTGCA
GAACCGGATGATCCACAAGATGCAGTAGTAGCAAATCAGTACAAACAAAATCCTGAAATG
TTCAAACAGACAGCTCGACTTTGGGCACATGTGTATGCTGGAGCACCAGTTTCTAGTCCA
GAGTACACCAAAAAAATAGAAAACCTATGTGCTATGGGCTTTGATAGGAATGCGGTAATA
GTGGCCTTGTCTTCAAAATCATGGGATGTAGAGACTGCAACAGAATTGCTTCTGAGTAAC
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 200 |
| Molecular Weight
| 22407.0 |
| Theoretical pI
| 5.1 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Ubiquitin-conjugating enzyme E2 K
MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEI
KIPETYPFNPPKVRFITKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSLQALLAAA
EPDDPQDAVVANQYKQNPEMFKQTARLWAHVYAGAPVSSPEYTKKIENLCAMGFDRNAVI
VALSSKSWDVETATELLLSN
|
| External Links |
|---|
| GenBank ID Protein
| AAB19536.1 |
| UniProtKB/Swiss-Prot ID
| P61085 |
| UniProtKB/Swiss-Prot Entry Name
| UBE2K_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| S51016 |
| GeneCard ID
| UBE2K |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
