| Identification |
|---|
| BMDB Protein ID
| BMDBP00985 |
| Secondary Accession Numbers
| None |
| Name
| Ubiquitin-conjugating enzyme E2 S |
| Synonyms
|
Not Available
|
| Gene Name
| UBE2S |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination. |
| Pathways
|
- Protein modification
- Protein ubiquitination
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| Not Available |
| SNPs
| UBE2S |
| Gene Sequence
|
>672 bp
ATGAACTCCAACGTGGAGAACCTGCCCCCCCACATCATCCGCCTGGTGTACAAGGAGGTG
ACGACGCTGACCGCTGACCCACCTGATGGCATCAAGGTCTTTCCCAACGAGGAAGACCTT
ACCGACCTGCAGGTCACCATTGAGGGCCCTGAGGGGACCCCGTATGCCGGAGGCCTCTTC
CGCATGAAACTCCTGCTGGGGAAGGACTTTCCGGCCTCCCCACCCAAGGGCTACTTCCTG
ACGAAGATCTTCCACCCGAATGTGGGCGCCAATGGCGAGATCTGCGTCAATGTGCTCAAG
AGGGACTGGACCGCTGAGCTGGGCATCCGGCACGTGCTTCTGACCATCAAGTGCCTGCTG
ATCCACCCCAACCCCGAGTCGGCCCTCAACGAGGAGGCGGGCCGCCTGCTGCTGGAGAAC
TACGAGGAGTACGCAGCCCGCGCGCGCCTGCTCACTGAGATCCACGGCGGCGCCGGCGGG
CCCAGCGGTGGGAGGCCCGAGCCCGGCCGGGCCACTGCCAGTGGGGCGGCGGCCTCCACT
GCTGACCCCACAGCCACTGGGGGCCCAGCAGGGGCTGAGGGGCCCATGGCCAAGAAGCAC
GCGGGCGAGCGCGACAAGAAGCTGGCAGCCAAGAAAAAGACGGACAAGAAGCGGGCACTG
CGGCGCCTGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 223 |
| Molecular Weight
| 23896.0 |
| Theoretical pI
| 9.05 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Ubiquitin-conjugating enzyme E2 S
MNSNVENLPPHIIRLVYKEVTTLTADPPDGIKVFPNEEDLTDLQVTIEGPEGTPYAGGLF
RMKLLLGKDFPASPPKGYFLTKIFHPNVGANGEICVNVLKRDWTAELGIRHVLLTIKCLL
IHPNPESALNEEAGRLLLENYEEYAARARLLTEIHGGAGGPSGGRPEPGRATASGAAAST
ADPTATGGPAGAEGPMAKKHAGERDKKLAAKKKTDKKRALRRL
|
| External Links |
|---|
| GenBank ID Protein
| AAI14839.1 |
| UniProtKB/Swiss-Prot ID
| Q1RML1 |
| UniProtKB/Swiss-Prot Entry Name
| UBE2S_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC114838 |
| GeneCard ID
| UBE2S |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
