| Identification |
|---|
| BMDB Protein ID
| BMDBP00987 |
| Secondary Accession Numbers
| None |
| Name
| Aldo-keto reductase family 1 member A1 |
| Synonyms
|
Not Available
|
| Gene Name
| AKR1A1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in alcohol dehydrogenase (NADP+) activity |
| Specific Function
| Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (By similarity). Plays an important role in ascorbic acid biosynthesis by catalyzing the reduction of D-glucuronic acid and D-glucurono-gamma-lactone (By similarity). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic. Involved also in the detoxification of lipid-derived aldehydes like acrolein (By similarity). Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs (By similarity). Displays no reductase activity towards retinoids (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| AKR1A1 |
| Gene Sequence
|
>978 bp
ATGGCGGCTTCCTGTATCCTCCTACACACTGGGCAGAAGATGCCCCTGATTGGACTGGGC
ACCTGGAAGAGCGACCCTGGCCAGGTTAAAGCAGCTATTAAGTATGCCCTGAGTGTAGGC
TACCGTCACATTGACTGTGCTGCTATCTATGGCAATGAGACTGAAATCGGGGAAGCCCTG
AAGGAGAATGTGGGACCTGGCAAGTTGGTGCCTCGGGAGGAGCTCTTTGTGACTTCCAAG
CTGTGGAACACAAAGCACCACCCCGAGGATGTGGAGCCTGCCCTCCGGAAGACACTTGCT
GACCTGCAGCTGGAGTATCTGGACCTGTACCTGATGCACTGGCCTTACGCCTTTGAGCGG
GGAGACAGCCCCTTCCCTAAGAATGCTGATGGGACTATACGCTATGACTCCACCCACTAC
AAGGAGACCTGGAGGGCTCTGGAGGCACTCGTGGCTAAGGGGCTGGTGCGGGCTCTGGGC
CTGTCCAACTTCAACAGTCGGCAGATTGACGATGTGCTCAGCGTGGCCTCTGTACGCCCA
GCTGTCCTGCAGGTGGAATGCCACCCATACCTGGCTCAGAATGAGCTGATTGCCCACTGC
CAAGCACGAAACCTGGAGGTGACTGCTTATAGCCCTCTGGGCTCCTCTGATCGTGCGTGG
CGTGATCCTGAGGAGCCTGTCCTGCTTAAGGAGCCAGTGGTCCTGGCACTGGCAGAAAAG
CATGGTCGATCTCCAGCTCAGATCTTGCTCAGGTGGCAGGTCCAGCGGAAAGTGAGCTGC
ATCCCCAAGAGTGTCACGCCTTCCCGTATCCTTGAGAACATCCAGGTGTTTGACTTCACC
TTTAGCCCAGAGGAGATGAAGCAGCTGGATGCCCTGAATAAAAATTTGCGATTCATTGTG
CCCATGCTTACGGTGGATGGGAAGAGGGTCCCAAGAGATGCAGGGCACCCTCTGTACCCC
TTCAATGACCCATATTGA
|
| Protein Properties |
|---|
| Number of Residues
| 325 |
| Molecular Weight
| 36617.0 |
| Theoretical pI
| 7.31 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Alcohol dehydrogenase [NADP+]
MAASCILLHTGQKMPLIGLGTWKSDPGQVKAAIKYALSVGYRHIDCAAIYGNETEIGEAL
KENVGPGKLVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER
GDSPFPKNADGTIRYDSTHYKETWRALEALVAKGLVRALGLSNFNSRQIDDVLSVASVRP
AVLQVECHPYLAQNELIAHCQARNLEVTAYSPLGSSDRAWRDPEEPVLLKEPVVLALAEK
HGRSPAQILLRWQVQRKVSCIPKSVTPSRILENIQVFDFTFSPEEMKQLDALNKNLRFIV
PMLTVDGKRVPRDAGHPLYPFNDPY
|
| External Links |
|---|
| GenBank ID Protein
| AAI02167.1 |
| UniProtKB/Swiss-Prot ID
| Q3ZCJ2 |
| UniProtKB/Swiss-Prot Entry Name
| AK1A1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC102166 |
| GeneCard ID
| AKR1A1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
