| Identification |
|---|
| BMDB Protein ID
| BMDBP00989 |
| Secondary Accession Numbers
| |
| Name
| Aldehyde dehydrogenase family 3 member B1 |
| Synonyms
|
Not Available
|
| Gene Name
| ALDH3B1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. Can use both NADP(+) and NAD(+) as electron acceptor. May have a protective role against the cytotoxicity induced by lipid peroxidation. |
| Pathways
|
- Acetate from ethanol: step 2/2
- Alcohol metabolism
- Ethanol Degradation
|
| Reactions
|
| Pristanal + NAD + Water → Pristanic acid + NADH |
details
|
| Glyceric acid + NADP + Water → Glyceraldehyde + NADPH |
details
|
| Homovanillin + NADP + Water → p-Hydroxyphenylacetic acid + NADPH |
details
|
| 3-Methoxy-4-hydroxyphenylglycolaldehyde + NADP + Water → Vanillylmandelic acid + NADPH |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 29 |
| Locus
| Not Available |
| SNPs
| ALDH3B1 |
| Gene Sequence
|
>1407 bp
ATGGACCCCTTTGCAGATACCCTGCAGCGGCTGCGGGAAGCCTTCGTCTCGGGGCGCACG
CGGCCGGCCGAGTTCCGGGACGCCCAGCTGAAGGGCCTGAGCCGCTTCCTGCGAGAGAAC
AAGCAGCTTCTGCAGGAGGCGCTGGCTCAGGACCTGCACAAGTCAGCCTTCGAGGCAGAG
GTGTCTGAAATCAGCATTAGCCAGAACGAGATTAACTTGGCCCTTAGGAACCTGAGGACC
TGGATGAAGGATGAGAAAGTGTCCAAGAACCTGGCCACGCAGCTGGACTCGGCCTTCATC
CGGAAGGAGCCCTTTGGCCTGGTGCTCATCCTGTCTCCCTGGAACTATCCTCTGAACCTG
AGCCTGGGGCCCCTGGTGGGTGCCCTCGCAGCAGGGAACTGCGTGGTGCTGAAACCCTCG
GAGATCAGCAAGAACACTGAGAAGGTCCTGGCCGAGGTGCTGCCCCGATACCTGGACCAG
AGCTGCTTTGCCGTGGTGCTGGGTGGGCCCCAGGAGACAGGGCGGCTGCTGGAGCACAAG
TTCGACTACATATTCTTCACGGGGAACCCTCAAGTTGGCAAGATTGTCATGACTGCCGCC
GCCAAGCACCTGACGCCCGTCACGCTGGAGCTGGGAGGCAAGAACCCCTGCTACGTGGAC
GACAACTGCGACCCCCAGACCGTGGCCAACCGGGTGGCCTTCTTTCGCTGTTTCAACGCT
GGCCAGACCTGCGTGGCCCCCGACTATGTCCTGTGCAGTCCCGAGATGCAGGCGCAGCTG
GTGCCCGCCCTGCAGAGCGCCATCACCCGTTTCTATGGCGACGACCCCCAGAGCTCCCCA
AACCTGGGCCGCATCATCAGCCAGAAGCATTTCCAGCGGCTCCGGGGCCTGCTGAGCTGT
GGCCGCGTGGTCATCGGCGGCCAGAGTGACGAATGCGATCTCTACATCGCCCCCACGGTG
CTGGTGGACGTGCAGGAGACCGATCCGGTGATGCAGGAGGAAATCTTCGGGCCCATCCTA
CCTATCGTGAACGTGAGGAGCCTGGGCCAGGCCATCGACTTCATCAACCGTCGGGAGAAG
CCCCTGGCCCTGTACGCCTTCTCCAACAGCAGCCAGGTGGTCAAGCGGGTCCTGGCCCAG
ACCAGCAGCGGGGGCTTCTGCGGGAACGACGGCTTCATGCACTTGACCCTGGCCAGCCTG
CCTTTCGGAGGAGTGGGCAGCAGCGGGATGGGCAATTACCACGGCAAGTTCTCCTTCGAC
ACCTTCTCCCACCACCGCGCCTGCCTGCTGCGCCGCCCCGGGCTGGAGAAGATCTACGCC
ATCCGCTACCCGCCCCACACTCCGCGCAACCTGAGGGTGCTGCTGATGGCCATGGAGACC
CGCAGCTGCAGCTGCACCCTGCTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 468 |
| Molecular Weight
| 51800.0 |
| Theoretical pI
| 8.12 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Aldehyde dehydrogenase family 3 member B1
MDPFADTLQRLREAFVSGRTRPAEFRDAQLKGLSRFLRENKQLLQEALAQDLHKSAFEAE
VSEISISQNEINLALRNLRTWMKDEKVSKNLATQLDSAFIRKEPFGLVLILSPWNYPLNL
SLGPLVGALAAGNCVVLKPSEISKNTEKVLAEVLPRYLDQSCFAVVLGGPQETGRLLEHK
FDYIFFTGNPQVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAFFRCFNA
GQTCVAPDYVLCSPEMQAQLVPALQSAITRFYGDDPQSSPNLGRIISQKHFQRLRGLLSC
GRVVIGGQSDECDLYIAPTVLVDVQETDPVMQEEIFGPILPIVNVRSLGQAIDFINRREK
PLALYAFSNSSQVVKRVLAQTSSGGFCGNDGFMHLTLASLPFGGVGSSGMGNYHGKFSFD
TFSHHRACLLRRPGLEKIYAIRYPPHTPRNLRVLLMAMETRSCSCTLL
|
| External Links |
|---|
| GenBank ID Protein
| ABF57409.1 |
| UniProtKB/Swiss-Prot ID
| Q1JPA0 |
| UniProtKB/Swiss-Prot Entry Name
| AL3B1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT025453 |
| GeneCard ID
| ALDH3B1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
