| Identification |
|---|
| BMDB Protein ID
| BMDBP00991 |
| Secondary Accession Numbers
| None |
| Name
| Alcohol dehydrogenase class-3 |
| Synonyms
|
Not Available
|
| Gene Name
| ADH5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. |
| Pathways
|
- Ethanol Degradation
- Retinol Metabolism
- Tyrosine Metabolism
|
| Reactions
|
| 3,4-Dihydroxymandelaldehyde + NAD → NADH + 3,4-Dihydroxyphenylglycol |
details
|
| 11-cis-Retinaldehyde + NAD → Retinal + NADH |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| Not Available |
| SNPs
| ADH5 |
| Gene Sequence
|
>1125 bp
ATGGCGAACCAGGTTATCAAGTGCAAGGCTGCAGTTGCCTGGGAGGCTGGGAAGCCTCTT
TCTATAGAGGAGGTAGAGGTGGCACCCCCAAAGGCTCATGAAGTTCGAATTAAGATTATT
GCCACTGCAGTTTGCCACACTGACGCCTATACACTGAGTGGGGCTGATCCTGAAGGGAAT
TATCCAGTGATCTTGGGACACGAAGGTGCTGGAATTGTGGAGAGTGTTGGTGAAGGAGTT
ACTAAGCTGAAGGCAGGTGATACTGTCATCCCACTTTACATCCCCCAGTGTGGAGAATGC
AAGTTTTGTCTGAATCCTAAAACAAACCTTTGCCAGAAGATAAGAGTCACTCAAGGAAAA
GGATTAATGCCAGATGGCACTAGCAGATTTACTTGTAAAGGAAAGACAATTTTACATTAC
ATGGGAACCAGCACATTTTCTGAATACACAGTTGTGGCTGACATTTCTGTTGCTAAAATT
GATCCTTTAGCACCTTTGGATAAAGTTTGCCTTCTGGGTTGTGGCATTTCAACTGGCTAT
GGTGCTGCTTTGAATGCTGCCAAGGTGGAGCCTGGCTCTACTTGTGCTGTCTTTGGCCTG
GGAGGAGTTGGATTGGCAGTTATCATGGGCTGTAAGATGGCTGGTGCAGCCCGGATCATT
GGTGTGGACATCAATAAGGATAAATTCGCAAGAGCCAAGGAGTTCGGGGCCTCTGAGTGT
ATTAACCCCCAGGACTTCAGTAAACCGATCCAGGAAGTGCTCATTGAGATGACTGACGGG
GGAGTCGACTACTCCTTTGAGTGTATTGGTAATGTGAAAGTCATGAGAGCAGCGCTGGAG
GCCTGCCACAAAGGCTGGGGCATCAGCGTGGTAGTGGGAGTAGCTGCCTCTGGTGAAGAA
ATCGCCACTCGTCCGTTCCAGCTAGTCACGGGCCGCACGTGGAAAGGCACTGCCTTTGGA
GGATGGAAGAGTGTAGAAAGTGTCCCAAAGTTGGTGTCTGAATATATGTCCAAAAAGATA
AAAGTTGATGAGTTTGTGACTCACAGTCTGCCTTTTGACCAAATTAATGAAGCCTTTGAT
CTGATGCATGCCGGAAAGAGCATCCGAACGGTTGTAAAGCTTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 374 |
| Molecular Weight
| 39677.0 |
| Theoretical pI
| 7.56 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Alcohol dehydrogenase class-3
MANQVIKCKAAVAWEAGKPLSIEEVEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPEGN
YPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGK
GLMPDGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGY
GAALNAAKVEPGSTCAVFGLGGVGLAVIMGCKMAGAARIIGVDINKDKFARAKEFGASEC
INPQDFSKPIQEVLIEMTDGGVDYSFECIGNVKVMRAALEACHKGWGISVVVGVAASGEE
IATRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTHSLPFDQINEAFD
LMHAGKSIRTVVKL
|
| External Links |
|---|
| GenBank ID Protein
| AAI02927.1 |
| UniProtKB/Swiss-Prot ID
| Q3ZC42 |
| UniProtKB/Swiss-Prot Entry Name
| ADHX_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC102926 |
| GeneCard ID
| ADH5 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
