1.0 2018-05-07 22:24:59 UTC 2020-05-20 21:09:22 UTC BMDBP01002 Enzyme IMPDH2 Nucleotide transport and metabolism Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. Purine Metabolism SMP0087239 XMP biosynthesis via de novo pathway XMP from IMP: step 1/1 BMDB0000175 Inosinic acid BMDB0000189 Inosine triphosphate BMDB0000586 Potassium BMDB0000902 NAD BMDB0001487 NADH BMDB0001554 Xanthylic acid 22 >1545 bp ATGGCCGACTACCTGATTAGCGGGGGCACGTCTTATGTGCCGGACGACGGGCTCACGGCA CAGCAGCTGTTCAACTGCGGGGACGGCCTCACCTACAATGACTTTCTCATTCTCCCCGGG TACATCGACTTCACTGCAGACCAAGTGGACCTGACCTCTGCTCTAACTAAAAAGATCACT CTGAAGACCCCACTGGTTTCCTCACCCATGGACACAGTCACAGAGGCTGGGATGGCCATA GCAATGGCGCTTACGGGTGGTATTGGCTTCATTCATCACAATTGTACACCAGAATTCCAG GCCAATGAAGTTCGGAAAGTGAAGAAATATGAGCAGGGATTCATCACAGACCCTGTGGTC CTCAGTCCCAGGGATCGCGTGAGGGATGTGTTTGAAGCCAAGGCCCGGCATGGGTTCTGT GGTATCCCCATCACTGACACAGGCCGGATGGGAAGCCACCTGGTGGGCATCATCTCCTCA AGGGACATTGATTTTCTCAAGGAGGAAGAGCATGACCGGCTTTTGGGAGAGATCATGACA AAGAGGGAAGACTTGGTGGTAGCCCCTGCAGGCATCACATTGAAAGAAGCAAATGAAATT CTGCAGCGTAGCAAGAAGGGAAAGTTACCCATTGTAAATGAAAATGATGAGCTGGTGGCC ATCATTGCCCGGACAGACCTGAAGAAAAACCGAGATTACCCACTGGCCTCCAAAGATGCC AAGAAGCAGCTGCTGTGTGGAGCAGCCATTGGCACTCATGAGGATGACAAGTATCGGCTA GACTTGCTGTCCCAGGCCGGTGTGGACGTAGTGGTTTTGGATTCTTCCCAAGGAAACTCC ATCTTCCAGATCAACATGATCAAGTACATCAAAGAGAAATACCCCAGTATCCAAGTCATT GGAGGGAATGTGGTCACGGCTGCTCAGGCCAAGAACCTCATTGATGCTGGCGTAGATGCC CTGCGGGTGGGAATGGGCAGTGGCTCCATCTGCATCACTCAGGAAGTGCTGGCCTGCGGG CGGCCCCAAGCAACAGCTGTTTACAAGGTGTCAGAATATGCGCGGCGTTTTGGTGTTCCT GTCATTGCTGACGGAGGAATCCAAAATGTGGGCCATATTGCCAAAGCTTTGGCCCTTGGA GCCTCCACAGTTATGATGGGCTCCCTCCTGGCTGCTACCACTGAGGCCCCTGGCGAGTAC TTCTTCTCTGATGGAATCCGGCTAAAGAAGTACCGTGGTATGGGTTCTCTCGATGCCATG GACAAGCATCTCAGCAGCCAGAATCGATATTTCAGTGAAGCAGACAAAATCAAGGTGGCC CAGGGGGTGTCTGGGGCTGTTCAGGATAAAGGATCCATCCATAAGTTTGTTCCCTACCTG ATTGCTGGCATCCAGCACTCCTGCCAGGATATTGGTGCCAAGAGTCTGACCCAAGTTCGA GCCATGATGTATTCTGGGGAGCTCAAGTTTGAGAAGAGAACATCCTCAGCCCAGGTGGAA GGTGGTGTCCACAGCCTCCATTCGTATGAGAAGCGTCTTTTCTGA 514 55763.0 7.34 None >Inosine-5'-monophosphate dehydrogenase 2 MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVV LSPRDRVRDVFEAKARHGFCGIPITDTGRMGSHLVGIISSRDIDFLKEEEHDRLLGEIMT KREDLVVAPAGITLKEANEILQRSKKGKLPIVNENDELVAIIARTDLKKNRDYPLASKDA KKQLLCGAAIGTHEDDKYRLDLLSQAGVDVVVLDSSQGNSIFQINMIKYIKEKYPSIQVI GGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVP VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF AAI04603.1 Q3SWY3 IMDH2_BOVIN 1JR1 BC104602 IMPDH2