1.0 2018-05-07 22:24:59 UTC 2020-05-20 22:25:39 UTC BMDBP01003 Enzyme IMPDH1 Nucleotide transport and metabolism Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. Purine Metabolism SMP0087239 XMP biosynthesis via de novo pathway XMP from IMP: step 1/1 BMDB0000175 Inosinic acid BMDB0000189 Inosine triphosphate BMDB0000586 Potassium BMDB0000902 NAD BMDB0001487 NADH BMDB0001554 Xanthylic acid BMDB0002111 Water 4 >1716 bp ATGGAGGAGCCACGCGCTCCGCCAGCAGGGTCGGCGCCGTTCCCGGTGTCTCTGCAGGGA GGCGGAACCGCTGATGTTCCGGAGCCCGGAGCCCGGCAGCACCCGGGACACGAGACGGCG GCGCAACGGTACAGCGCCCGCCTGCTGCAGGCCGGCTACGAGCCCGAGAGCATGGCGGAC TACCTGATCAGCGGCGGCACCGGTTACGTGCCCGAGGATGGGCTCACTGCGCAGCAGCTG TTCGCCAACGCCGACGGCCTCACCTACAACGACTTCCTGATTCTCCCAGGATTCATAGAC TTCACAGCTGATGAAGTGGATCTGACTTCAGCCCTGACTCGGAAGATCACACTAAAGACG CCACTCATCTCATCCCCCATGGACACTGTGACGGAGGCTGACATGGCCATTGCAATGGCT CTGATGGGCGGTATTGGTTTCATTCACCACAACTGCACTCCAGAATTCCAGGCCAATGAG GTGCGGAAGGTCAAGAAATTTGAACAGGGCTTCATCACGGACCCCGTGGTACTAAGCCCC TCGCATACCGTGGGTGACGTGCTGGAGGCCAAGATCCGGCATGGCTTCTCAGGCATCCCC ATCACTGAGACGGGCACCATGGGCAGCAAGCTGGTGGGCATTGTCACCTCCCGAGACATC GACTTCCTTGCCGAGAAGGACCACACCACCCTTCTCAGTGAGGTGATGACCCCACGGAAT GAGCTGGTGGTGGCTCCAGCAGGTGTAACATTGAAAGAGGCAAATGAGATTCTGCAGCGC AGCAAGAAAGGAAAGCTGCCCATTGTCAATGATCGAGATGAGTTAGTGGCCATCATTGCC CGCACTGACCTGAAGAAGAACCGGGACTACCCCCTGGCCTCCAAGGATTCCCACAAGCAG CTGCTGTGCGGGGCGGCTGTGGGCACCCGTGAGGATGACAAATACCGCCTGGACCTGCTC ACCCAGGCGGGCGCTGATGTCATAGTGCTGGACTCATCCCAAGGGAACTCTGTGTATCAG ATCGCCATGGTACACTACATTAAGCAGAAGTACCCCCACCTCCAGGTGATTGGGGGCAAT GTGGTGACAGCAGCTCAGGCCAAGAACCTGATTGACGCTGGTGTGGATGGGCTGCGTGTG GGCATGGGATGCGGCTCCATCTGCATCACCCAGGAAGTGATGGCCTGTGGTCGGCCCCAG GGCACTGCCGTGTACAAAGTGGCTGAGTATGCCCGGCGCTTCGGGGTCCCAGTCATAGCC GACGGCGGCATCCAGACCGTGGGGCACGTGGTTAAGGCGCTGGCCCTCGGAGCCTCCACA GTGATGATGGGTTCCCTGCTCGCGGCCACCACGGAGGCCCCCGGCGAATACTTCTTCTCG GATGGTGTGAGGCTCAAGAAGTACCGCGGCATGGGCTCGCTGGACGCCATGGAGAAGAGC AGCAGCAGCCAGAAACGCTACTTCAGCGAGGGGGACAAGGTGAAGATTGCGCAGGGCGTC TCGGGCTCTATCCAGGACAAAGGCTCCATTCAGAAGTTCGTGCCCTACCTCATAGCGGGC ATCCAGCACGGCTGCCAGGACATCGGGGCCCGGAGTCTGTCTGTCCTGCGGTCCATGATG TACTCAGGAGAGCTCAAGTTTGAGAAGCGGACCATGTCGGCCCAGATCGAGGGCGGCGTC CACGGCCTGCACTCTTACGAGAAGCGGCTGTACTGA 514 55424.0 6.75 None >Inosine-5'-monophosphate dehydrogenase MEEPRAPPAGSAPFPVSLQGGGTADVPEPGARQHPGHETAAQRYSARLLQAGYEPESMAD YLISGGTGYVPEDGLTAQQLFANADGLTYNDFLILPGFIDFTADEVDLTSALTRKITLKT PLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVVLSP SHTVGDVLEAKIRHGFSGIPITETGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMTPRN ELVVAPAGVTLKEANEILQRSKKGKLPIVNDRDELVAIIARTDLKKNRDYPLASKDSHKQ LLCGAAVGTREDDKYRLDLLTQAGADVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVIGGN VVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVPVIA DGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAMEKS SSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLRSMM YSGELKFEKRTMSAQIEGGVHGLHSYEKRLY AAI26585.1 A0JNA3 IMDH1_BOVIN 1JCN DAAA02011497 IMPDH1