1.0 2018-05-07 22:25:00 UTC 2020-05-20 21:00:57 UTC BMDBP01008 Enzyme CBR4 Lipid transport and metabolism The heterotetramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD. The homotetramer has NADPH-dependent quinone reductase activity. Both homotetramer and the heterotetramer have broad in vitro substrate specificity and can reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones. Fatty Acid Biosynthesis SMP0087257 Lipid metabolism BMDB0000217 NADP BMDB0000902 NAD 8 >714 bp ATGGACAAGGTGTGCGCCGTGTTCGGAGGCTCCCGGGGCATCGGCAGGGCGGTGGCCCGC CTGATGGCCCAGAGAGGCTATCGACTGGCCATCGTCGCCCGGAATCTGGAGGGGGCCAGA GCCGCGGCCGGGGACCTCGGCGGAGACCATTTGGCATTGAGCTGTGATGTTGCCAAAGAA CATGATGTTCAAAATACATTTGAAGAGATAGAGAAAAATTTAGGTCGCGTTAATTTCTTG GTAAATGCAGCTGGAATTAACAGGGATAACCTCTTAGTAAGGACAAATACTGAAGATATG CTCTCTCAGCTCCATACTAACCTCCTGGGCTCCATGCTGACCTGTAGAGCTGCCCTGAAG ACAATGATTAAACAGCAGAGAGGGTCCATTGTGAATGTAGGAAGTGTTGTTGGTTTAAAA GGCAATTCCGGCCAGTCTGTATACAGTGCCAGTAAAGGAGGATTAGTCGGATTTTCACGT GCTCTTGCCAAAGAAGTAGCAAAAAAGAAAATTAGAGTGAATGTAGTTGCACCAGGATTC ATTCACACAGATATGACAAAAGACTTGAATGAAGAACTTTTAAAGAAGAATATCCCTCTG GGAAGGTTTGGAGACGCCCTTGACGTGGCCCAGGCAGCCGTATTTCTTCTAGAGTCGCCG TATGTGACAGGGCACGTCCTGGTGGTGGATGGCGGCCTGCAGCTCACCATGTAG 237 25269.0 9.97 None >Carbonyl reductase 4 MDKVCAVFGGSRGIGRAVARLMAQRGYRLAIVARNLEGARAAAGDLGGDHLALSCDVAKE HDVQNTFEEIEKNLGRVNFLVNAAGINRDNLLVRTNTEDMLSQLHTNLLGSMLTCRAALK TMIKQQRGSIVNVGSVVGLKGNSGQSVYSASKGGLVGFSRALAKEVAKKKIRVNVVAPGF IHTDMTKDLNEELLKKNIPLGRFGDALDVAQAAVFLLESPYVTGHVLVVDGGLQLTM AAI34483.1 A4IFA7 CBR4_BOVIN BC134482 CBR4