| Identification |
|---|
| BMDB Protein ID
| BMDBP01014 |
| Secondary Accession Numbers
| None |
| Name
| Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating |
| Synonyms
|
Not Available
|
| Gene Name
| NSDHL |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Cell wall/membrane/envelope biogenesis |
| Specific Function
| Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis. |
| Pathways
|
- Steroid Biosynthesis
- Zymosterol biosynthesis
- Zymosterol from lanosterol: step 4/6
|
| Reactions
|
| 4a-Methylzymosterol-4-carboxylic acid + NADP → 3-Keto-4-methylzymosterol + NADPH + Carbon dioxide |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| X |
| Locus
| Not Available |
| SNPs
| NSDHL |
| Gene Sequence
|
>1071 bp
ATGGAACAAGCAGCTGGTGAGCCAACAAGGACATGTTTGACAGAAGACATTCCAAAAGCC
AAGAGGTGCACGGTGATTGGAGGCTGTGGGTTCCTGGGTCAGCACATGGTGGAGCAGTTG
CTAGCAAGAGGCTATGCTGTCAATGTATTTGACATTCGGCAAGGGTTTGACAATCCTCGT
GTGCAGTTTTTCCTGGGTGACCTTTGCAGCCAACAGGACCTGTACCCAGCTCTGAAAGGT
GTAAGCACAGTTTTCCACTGCGCATCGCCCCCACCATTCAATAACAACAAGGAACTCTTT
TATAGAGTGAATTACATTGGCACCAAGAATGTCATTGAAACCTGCAAAGAGGCTGGGGTT
CAGAAACTCATTTTAACCAGCAGTGCCAGTGTCATCTTTGAGGGTGTTGACATCAAGAAT
GGAACTGAAGACCTCCCTTATGCCACGAAACCCATTGACTACTACACGGAGACAAAGATC
TTACAAGAGAGAGCAGTCCTGGGTGCCCATGATCCCGAGAAGAATTTCCTGACCACAGCC
ATCCGCCCTCATGGCATTTTTGGCCCAAGGGACCCCCAGTTAGTCCCCATTCTCATTGAG
GCAGCCAAGAAAGGCAAGATGAAGTTCATGATTGGGAACGGAAAGAACTTGGTAGACTTT
ACCTTTGTGGAGAACGTGGTCCACGGACACATCCTGGCTGCAGAGCACCTCTCCCAGGAC
ACCGCCTTGGGTGGGAAGGCTTTTCACATCACCAACGACGAGCCCATCCCCTTCTGGACT
TTCCTGTCCCGAATCCTGACAGGCCTCAATTATGAAGCCCCCAAGTACCACATCCCCTAC
TGGCTGGCCTACTATCTAGCCCTCCTTGTGTCCCTCCTGGTGATGGTGATCAGTCCTGTC
ATCCAGCTTCAGCCCACTTTCACGCCTATGCGGGTCGCACTGGCTGGCACTTTCCACTAC
TACAGCTGCGAGAAAGCCAAAAAACTCATGGGCTACCGGCCGCTGGTCACCATGGATGAT
GCTGTGGACAAGACCGTGAGGAGCTTTCACCACCTGCGCAAGGTCATGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 356 |
| Molecular Weight
| 39902.0 |
| Theoretical pI
| 8.27 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
MEQAAGEPTRTCLTEDIPKAKRCTVIGGCGFLGQHMVEQLLARGYAVNVFDIRQGFDNPR
VQFFLGDLCSQQDLYPALKGVSTVFHCASPPPFNNNKELFYRVNYIGTKNVIETCKEAGV
QKLILTSSASVIFEGVDIKNGTEDLPYATKPIDYYTETKILQERAVLGAHDPEKNFLTTA
IRPHGIFGPRDPQLVPILIEAAKKGKMKFMIGNGKNLVDFTFVENVVHGHILAAEHLSQD
TALGGKAFHITNDEPIPFWTFLSRILTGLNYEAPKYHIPYWLAYYLALLVSLLVMVISPV
IQLQPTFTPMRVALAGTFHYYSCEKAKKLMGYRPLVTMDDAVDKTVRSFHHLRKVM
|
| External Links |
|---|
| GenBank ID Protein
| AAI03390.1 |
| UniProtKB/Swiss-Prot ID
| Q3ZBE9 |
| UniProtKB/Swiss-Prot Entry Name
| NSDHL_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC103389 |
| GeneCard ID
| NSDHL |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
