<?xml version="1.0" encoding="UTF-8"?>
<protein>
  <version>1.0</version>
  <creation_date>2018-05-07 22:25:04 UTC</creation_date>
  <update_date>2020-05-20 21:04:49 UTC</update_date>
  <accession>BMDBP01022</accession>
  <secondary_accessions>
    <accession>BMDBP03125</accession>
  </secondary_accessions>
  <protein_type>Enzyme</protein_type>
  <synonyms>
  </synonyms>
  <gene_name>HSD3B</gene_name>
  <general_function>Cell wall/membrane/envelope biogenesis</general_function>
  <specific_function>3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.</specific_function>
  <pathways>
    <pathway>
      <name>Lipid metabolism</name>
      <smpdb_id/>
      <kegg_map_id/>
    </pathway>
    <pathway>
      <name>Steroid Biosynthesis</name>
      <smpdb_id>SMP0087233</smpdb_id>
      <kegg_map_id/>
    </pathway>
  </pathways>
  <metabolite_associations>
    <metabolite>
      <accession>BMDB0000902</accession>
      <name>NAD</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0001487</accession>
      <name>NADH</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0012454</accession>
      <name>3 beta,7 alpha-Dihydroxy-5-cholestenoate</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0012458</accession>
      <name>7 alpha-Hydroxy-3-oxo-4-cholestenoate</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0006281</accession>
      <name>7-a,27-dihydroxycholesterol</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000217</accession>
      <name>NADP</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0012459</accession>
      <name>7 alpha,26-Dihydroxy-4-cholesten-3-one</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000221</accession>
      <name>NADPH</name>
    </metabolite>
  </metabolite_associations>
  <go_classifications>
  </go_classifications>
  <subcellular_locations>
  </subcellular_locations>
  <gene_properties>
    <chromosome_location>3</chromosome_location>
    <locus>3q12</locus>
    <gene_sequence>&gt;1122 bp
ATGGCAGGGTGGAGCTGCCTCGTGACCGGAGGAGGAGGCTTTCTGGGCCAGAGGATCATC
TGCCTGTTGGTGGAGGAGAAGGATCTGCAGGAAATCCGGGTGCTAGACAAAGTCTTCAGA
CCAGAAGTTCGGGAGGAATTTTCTAAGCTCCAGAGCAAGATCAAGCTGACCCTGCTGGAA
GGAGACATTCTGGATGAGCAGTGCCTGAAGGGGGCCTGCCAGGGCACCTCAGTGGTCATC
CACACCGCCTCTGTCATTGACGTCAGGAATGCTGTCCCGCGAGAGACCATCATGAACGTC
AATGTGAAAGGTACCCAGCTGCTGTTGGAGGCCTGTGTCCAGGCCAGCGTACCGGTCTTT
ATCCACACCAGCACCATAGAAGTGGCTGGGCCCAACTCCTACAGGGAGATCATCCAAGAC
GGCCGTGAAGAAGAGCATCATGAATCGGCATGGTCCTCTCCATACCCATACAGCAAGAAG
CTTGCCGAGAAGGCTGTGCTGGGAGCTAATGGGTGGGCTCTGAAAAATGGTGGCACCTTG
TACACTTGTGCCCTGAGGCCCATGTACATCTACGGGGAGGGGAGCCCATTCCTTTCTGCC
TACATGCACGGAGCCTTGAATAACAACGGCATCCTGACCAATCACTGCAAGTTCTCAAGA
GTCAACCCAGTCTATGTTGGCAATGTGGCCTGGGCCCACATTCTGGCCTTGAGGGCCCTG
AGGGACCCCAAAAAGGTCCCAAACATCCAAGGACAGTTCTACTACATCTCAGACGACACG
CCACACCAAAGCTACGATGACCTCAATTACACTTTGAGCAAAGAATGGGGCTTCTGCCTG
GATTCCCGGATGAGCCTTCCTATTTCTCTGCAGTACTGGCTTGCCTTCCTGCTGGAAATA
GTGAGCTTCCTGCTCAGTCCAATTTACAAATATAACCCTTGCTTCAACCGCCACCTAGTG
ACTCTTTCCAACAGCGTGTTCACCTTCTCCTATAAGAAAGCTCAGCGAGATCTGGGGTAT
GAGCCCCTCTACACTTGGGAGGAAGCCAAGCAGAAAACCAAGGAGTGGATTGGCTCCCTG
GTGAAACAGCACAAAGAGACCCTGAAAACAAAGATTCACTGA</gene_sequence>
  </gene_properties>
  <protein_properties>
    <residue_number>373</residue_number>
    <molecular_weight>42220.0</molecular_weight>
    <theoretical_pi>7.96</theoretical_pi>
    <pfams>
    </pfams>
    <transmembrane_regions>
      <region>288-308</region>
    </transmembrane_regions>
    <signal_regions>
      <region>None</region>
    </signal_regions>
    <polypeptide_sequence>&gt;3 beta-hydroxysteroid dehydrogenase/Delta 5--&gt;4-isomerase
MAGWSCLVTGGGGFLGQRIICLLVEEKDLQEIRVLDKVFRPEVREEFSKLQSKIKLTLLE
GDILDEQCLKGACQGTSVVIHTASVIDVRNAVPRETIMNVNVKGTQLLLEACVQASVPVF
IHTSTIEVAGPNSYREIIQDGREEEHHESAWSSPYPYSKKLAEKAVLGANGWALKNGGTL
YTCALRPMYIYGEGSPFLSAYMHGALNNNGILTNHCKFSRVNPVYVGNVAWAHILALRAL
RDPKKVPNIQGQFYYISDDTPHQSYDDLNYTLSKEWGFCLDSRMSLPISLQYWLAFLLEI
VSFLLSPIYKYNPCFNRHLVTLSNSVFTFSYKKAQRDLGYEPLYTWEEAKQKTKEWIGSL
VKQHKETLKTKIH</polypeptide_sequence>
  </protein_properties>
  <genbank_protein_id>CAA35615.1</genbank_protein_id>
  <uniprot_id>P14893</uniprot_id>
  <uniprot_name>3BHS_BOVIN</uniprot_name>
  <pdb_ids>
  </pdb_ids>
  <genbank_gene_id>X17614</genbank_gene_id>
  <genecard_id>HSD3B</genecard_id>
  <geneatlas_id/>
  <general_references>
  </general_references>
  <metabolite_references>
  </metabolite_references>
</protein>
