| Identification |
|---|
| BMDB Protein ID
| BMDBP01023 |
| Secondary Accession Numbers
| None |
| Name
| Nucleoredoxin |
| Synonyms
|
Not Available
|
| Gene Name
| NXN |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Posttranslational modification, protein turnover, chaperones |
| Specific Function
| Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| NXN |
| Gene Sequence
|
>1308 bp
ATGTCGGGATTCCTGGAGGAGCTGCTGGGCGAGAAGCTAGTGACTGGCGGCGGCGAGGAG
GTGGACGTGCACTCGCTGGCCGCCCGCGGCATCTCGCTGCTCGGGCTCTACTTCGGCTGC
AGCCTGAGCGCCCCCTGCGCGCAGCTCAGCGCCAGCCTGGCCGCCTTCTACGGCCGCCTG
CGGGGGGACGCAGCGGCCGGGCCGGGGCCGGGGCCGGGGGCCGGGGCGTCGGCGGAGCCC
GAGCCGCGGCGCCGCCTGGAGATCGTCTTCGTGTCCTCGGATCAGGACCAGCGGCAGTGG
CAGGACTTCGTGCGGGACATGCCGTGGCTGGCGCTACCCTACAAGGAAAAGCACAGGAAG
CTTAAACTTTGGAACAAATATCGAATTTCCAACATTCCATCGCTCATATTCTTAGACGCC
ACTTCCGGGAAGGTCGTGTGCAGGAACGGGCTGCTGGTGATCCGCGATGACCCAGAGGGT
TTGGAATTCCCCTGGGGACCTAAACCCTTCAGGGAAGTCATTGCAGGGCCCTTGCTTAGA
AGTAACGGGCAGTCCCTGGAGAGCAGCAGCCTGGAGGGGTCTCACGTGGGAGTCTATTTC
TCCGCACACTGGTGTCCACCCTGCCGAAGCCTCACCCGGGTCCTAGTGGAGTCCTACCGG
AAGATCAAGGAGGCAGGCCAGAAATTCGAGATCATCTTTGTTAGTGCGGACAGGTCTGAG
GACTCATTCAAACAGTACTTCAGTGAGATGCCGTGGCTTGCAGTCCCCTACACCGACGAG
GCCCGGCGGTCGCGCCTCAACCGGCTGTATGGAATCCAAGGCATCCCCACGCTCATCGTG
CTGGACCCGCAGGGGGAGGTGATCACGCGGCAGGGACGGGTGGAGGTGCTGAATGACGAG
GACTGCAGGGGCTTCCCGTGGCACCCCAAGCCCGTGCTGGAGCTCTCCGACTCCAACGCC
GTGCAGCTCAACGAGGGCCCCTGCCTCGTCCTGTTTGTAGATTCTGAGGATGACGGCGAG
TCGGAGGCGGCCAAGCAGCTGATCCAGCCAATAGCTGAGAAGATCATTGCCAAGTACAAA
GCCAAAGAGGAGGAGGCGCCGCTCCTGTTCTTTGTGGCGGGGGAGGATGACATGACTGAC
TCCCTGCGAGATTACACCAACCTGCCCGAGGCTGCCCCTTTACTCACCATTCTGGACATG
TCAGCCCGGGCCAAGTACGTGATGGACGTGGAGGAGATCACCCCCGCCATTGTGGAGGCC
TTTGTGAATGACTTCCTAGCAGAAAAGCTCAAACCAGAGCCCATCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 435 |
| Molecular Weight
| 48331.0 |
| Theoretical pI
| 4.67 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Nucleoredoxin
MSGFLEELLGEKLVTGGGEEVDVHSLAARGISLLGLYFGCSLSAPCAQLSASLAAFYGRL
RGDAAAGPGPGPGAGASAEPEPRRRLEIVFVSSDQDQRQWQDFVRDMPWLALPYKEKHRK
LKLWNKYRISNIPSLIFLDATSGKVVCRNGLLVIRDDPEGLEFPWGPKPFREVIAGPLLR
SNGQSLESSSLEGSHVGVYFSAHWCPPCRSLTRVLVESYRKIKEAGQKFEIIFVSADRSE
DSFKQYFSEMPWLAVPYTDEARRSRLNRLYGIQGIPTLIVLDPQGEVITRQGRVEVLNDE
DCRGFPWHPKPVLELSDSNAVQLNEGPCLVLFVDSEDDGESEAAKQLIQPIAEKIIAKYK
AKEEEAPLLFFVAGEDDMTDSLRDYTNLPEAAPLLTILDMSARAKYVMDVEEITPAIVEA
FVNDFLAEKLKPEPI
|
| External Links |
|---|
| GenBank ID Protein
| AAI48093.1 |
| UniProtKB/Swiss-Prot ID
| A6QLU8 |
| UniProtKB/Swiss-Prot Entry Name
| NXN_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC148092 |
| GeneCard ID
| NXN |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
