<?xml version="1.0" encoding="UTF-8"?>
<protein>
  <version>1.0</version>
  <creation_date>2018-05-07 22:25:05 UTC</creation_date>
  <update_date>2020-05-20 21:08:36 UTC</update_date>
  <accession>BMDBP01026</accession>
  <secondary_accessions>
  </secondary_accessions>
  <protein_type>Enzyme</protein_type>
  <synonyms>
  </synonyms>
  <gene_name>ISYNA1</gene_name>
  <general_function>Lipid transport and metabolism</general_function>
  <specific_function>Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity).</specific_function>
  <pathways>
    <pathway>
      <name>Inositol Metabolism</name>
      <smpdb_id>SMP0087242</smpdb_id>
      <kegg_map_id/>
    </pathway>
    <pathway>
      <name>Inositol Phosphate Metabolism</name>
      <smpdb_id>SMP0087256</smpdb_id>
      <kegg_map_id/>
    </pathway>
    <pathway>
      <name>Myo-inositol biosynthesis</name>
      <smpdb_id/>
      <kegg_map_id/>
    </pathway>
    <pathway>
      <name>Myo-inositol from D-glucose 6-phosphate: step 1/2</name>
      <smpdb_id/>
      <kegg_map_id/>
    </pathway>
    <pathway>
      <name>Polyol metabolism</name>
      <smpdb_id/>
      <kegg_map_id/>
    </pathway>
  </pathways>
  <metabolite_associations>
    <metabolite>
      <accession>BMDB0000902</accession>
      <name>NAD</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0001401</accession>
      <name>Glucose 6-phosphate</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000213</accession>
      <name>Myo-inositol 1-phosphate</name>
    </metabolite>
  </metabolite_associations>
  <go_classifications>
  </go_classifications>
  <subcellular_locations>
  </subcellular_locations>
  <gene_properties>
    <chromosome_location>7</chromosome_location>
    <locus/>
    <gene_sequence>&gt;1674 bp
ATGGAGGCCGCAACTGAGTTCGTGGTCGAGAGCCCCGACGTTGTCTACAGCCCCGAGACC
ATCGAGGCGCAGTACGAGTACCGGACGACGAGCGTCAGCCGCGAGGGCGGCGTCCTCAAG
GTGCACCCCACGTCCACGCGCTTCACTTTCCGGACCGCCCGGCAGGTGCCCCGGCTCGGG
GTCATGCTCGTCGGCTGGGGCGGCAACAACGGCTCCACACTGACCGCTGCCGTGCTGGCT
AACCGACTGCGCTTGTCCTGGCCCACGCGCACGGGCCGCAAGGAGGCCAACTACTACGGC
TCACTGACGCAGGCAGGCACTGTTAGCCTGGGCCTGGACGCCGAGGGCAAGGAAGTGTTC
GTGCCCTTCAGTTCACTGCTGCCCATGGTGGCGCCCGACGACCTCGTGTTCGACGGCTGG
GACATATCTTCGCTGAACCTGGCGGAGGCGATGCGGCGTGCACAGGTACTGGACTGGGGA
CTGCAGGAGCAACTCTGGCCGCACATGGAGGCCATGCGCCCGCGGCCCTCCGTCTACATC
CCGGAGTTCATCGCAGCTAACCAGAGTGCGCGCGCCGACAACGTCATCCCGGGCACGCGC
GCGCAGCAGCTGGAGCAGATCCGTAGGGACATCCGCGACTTTCGGTTCAGCGCCGGCCTG
GACAAAGTCATCGTGCTGTGGACAGCGAACACGGAGCGCTTCTGCGAAGTGATTCCAGGC
CTCAATGACACTGCTGAGAACCTGCTGCGCACCATCCAGCTGGGCCTGGAAGTGTCGCCC
TCCACACTCTTTGCCGTGGCCAGCATCTTGGAGGGCTGTGCCTTCCTCAATGGGTCCCCA
CAGAACACGCTGGTACCCGGTGCCCTCGAGCTCGCGTGGCAGCGCCGCGTTTTTGTGGGT
GGAGACGACTTCAAGTCGGGCCAGACCAAGGTCAAATCTGTGCTCGTGGACTTCCTTATC
GGCTCTGGCCTCAAGACCATGTCCATCGTGAGCTACAACCACCTGGGCAACAACGACGGG
CAGAACTTGTCAGCGCCCCCACAGTTTCGCTCCAAGGAGGTGTCCAAGAGCAGCGTGGTG
GACGACATGGTGCACAGCAACCCGGTGCTCTACTCGCCGGGCGAACAGCCCGACCACTGC
GTGGTCATCAAGTACGTGCCATACGTGGGCGACAGCAAGCGTGCCCTGGATGAGTACACA
TCGGAGCTGATGCTGGGTGGTACCAACACGTTGGTGCTGCACAACACGTGCGAGGACTCG
CTCCTGGCCGCACCCATCATGCTGGACCTGGCCCTGCTGACTGAACTATGTCAGCGAGTG
AGCTTCTGCACCGACGTCGACCCGGACCCGCAGAGCTTCCATCCGGTGCTGTCACTGCTC
GGCTTCCTCTTCAAGGCGCCACTTGCACCACCCGGCAGCCCCGTAGTCAATGCGCTCTTC
CGCCAGCGCAGCTGCATCGAGAATATCCTCAGGGCCTGCGTGGGGCTCCCGCCGCAGAAC
CACATGCTTCTGGAGCACAAGATGGAACGCCCTGGCCTCAAGAGAGTTGGGCCCTTGGCC
ACCACCTCTCCGGTGCTTTGCAAGAAAGGATCTGCGCCGACCGCACCCAATGGCTGTACT
GGTGATGCCAATGGGCACTCACAGGCTGAGGCACCCCAGATGCCCACCACCTAA</gene_sequence>
  </gene_properties>
  <protein_properties>
    <residue_number>557</residue_number>
    <molecular_weight>60761.0</molecular_weight>
    <theoretical_pi>5.85</theoretical_pi>
    <pfams>
    </pfams>
    <transmembrane_regions>
    </transmembrane_regions>
    <signal_regions>
      <region>None</region>
    </signal_regions>
    <polypeptide_sequence>&gt;Inositol-3-phosphate synthase 1
MEAATEFVVESPDVVYSPETIEAQYEYRTTSVSREGGVLKVHPTSTRFTFRTARQVPRLG
VMLVGWGGNNGSTLTAAVLANRLRLSWPTRTGRKEANYYGSLTQAGTVSLGLDAEGKEVF
VPFSSLLPMVAPDDLVFDGWDISSLNLAEAMRRAQVLDWGLQEQLWPHMEAMRPRPSVYI
PEFIAANQSARADNVIPGTRAQQLEQIRRDIRDFRFSAGLDKVIVLWTANTERFCEVIPG
LNDTAENLLRTIQLGLEVSPSTLFAVASILEGCAFLNGSPQNTLVPGALELAWQRRVFVG
GDDFKSGQTKVKSVLVDFLIGSGLKTMSIVSYNHLGNNDGQNLSAPPQFRSKEVSKSSVV
DDMVHSNPVLYSPGEQPDHCVVIKYVPYVGDSKRALDEYTSELMLGGTNTLVLHNTCEDS
LLAAPIMLDLALLTELCQRVSFCTDVDPDPQSFHPVLSLLGFLFKAPLAPPGSPVVNALF
RQRSCIENILRACVGLPPQNHMLLEHKMERPGLKRVGPLATTSPVLCKKGSAPTAPNGCT
GDANGHSQAEAPQMPTT</polypeptide_sequence>
  </protein_properties>
  <genbank_protein_id>AAI11161.1</genbank_protein_id>
  <uniprot_id>Q2NL29</uniprot_id>
  <uniprot_name>INO1_BOVIN</uniprot_name>
  <pdb_ids>
  </pdb_ids>
  <genbank_gene_id>BC111160</genbank_gene_id>
  <genecard_id>ISYNA1</genecard_id>
  <geneatlas_id/>
  <general_references>
  </general_references>
  <metabolite_references>
  </metabolite_references>
</protein>
