| Identification |
|---|
| BMDB Protein ID
| BMDBP01027 |
| Secondary Accession Numbers
| None |
| Name
| Prostaglandin reductase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| PTGR1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in 15-oxoprostaglandin 13-oxidase activity |
| Specific Function
| Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha. Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4 (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| Not Available |
| SNPs
| PTGR1 |
| Gene Sequence
|
>990 bp
ATGGTTCATGCAAAGAGCTGGACCCTGAAGAAACATTTTGTAGGTTACCCTACTAACAGT
GACTTTGAACTGAAGACAGTTGAACTCCCACCCTTAAAAGATGGAGAGGTCCTGCTGGAA
GCTTTGTACTTGACTGTGGATCCTTACATGAGAATTATGGCAAAAAGCTTGAAGGAGGGT
GACATGATGATGGGAGAGCAAGTGGCCAGAGTTGTGGAAAGTAAAAATTCAGCCTTCCCA
ACAGGAACTATTGTGCTGGCTCCTTCTGGCTGGACAACGCATTCCATTTCTAATGGGGAA
AAACTGGAAAAGGTGCTTGCAGAGTGGCCAGACACGTTACCACTGTCTCTGGCTCTGGGA
ACGGTTGGCATGCCCGGCCTAACAGCCTACTTTGGCCTGTTGGACATCTGTGGAGTGAAG
GGTGGAGAAACAGTGCTGGTTAGTGCGGCAGCAGGAGCAGTGGGCTCTATTGTGGGGCAG
ATCGCTAAGCTCAAGGGCTGCAAAGTTGTTGGAACAGCAGGGTCTGATGAAAAAGTTGCT
TGGCTTAAAAAGCATGGATTTGATGTTGCCCTTAACTACAAAACAGTGAAGTCTTTGGAA
GAAGCTCTGAAAGAAGCTGCTCCCGAGGGTTATGATTGTTATTTTGATAATGTGGGTGGA
GAGTTTTCCAATGTTGCTATCACCCAGATGAAGAAATTTGGAAGAATTGCTATATGTGGG
GCCATCTCTGTATACAACAGAACCAGCCCACTTTCCCCAGGCCCATCCCCGGAAATCATC
ATCTTTAAGGAACTCCACTTGCAAGGCTTCGTCGTCTACCGCTGGCAAGGAGAAGTCCGC
CAGAAGGCTCTGAGAGACTTGCTGAAGTGGGTCTCAGAGGGTAAAATCCAGTACCATGAA
CATGTCACTGAAGGATTTGAAAACATGCCAGCTGCATTTATAGGATTGCTAAAAGGAGAG
AATCTGGGAAAGGCAATAGTGAAAGCATGA
|
| Protein Properties |
|---|
| Number of Residues
| 329 |
| Molecular Weight
| 35706.0 |
| Theoretical pI
| 7.57 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Prostaglandin reductase 1
MVHAKSWTLKKHFVGYPTNSDFELKTVELPPLKDGEVLLEALYLTVDPYMRIMAKSLKEG
DMMMGEQVARVVESKNSAFPTGTIVLAPSGWTTHSISNGEKLEKVLAEWPDTLPLSLALG
TVGMPGLTAYFGLLDICGVKGGETVLVSAAAGAVGSIVGQIAKLKGCKVVGTAGSDEKVA
WLKKHGFDVALNYKTVKSLEEALKEAAPEGYDCYFDNVGGEFSNVAITQMKKFGRIAICG
AISVYNRTSPLSPGPSPEIIIFKELHLQGFVVYRWQGEVRQKALRDLLKWVSEGKIQYHE
HVTEGFENMPAAFIGLLKGENLGKAIVKA
|
| External Links |
|---|
| GenBank ID Protein
| AAI02823.1 |
| UniProtKB/Swiss-Prot ID
| Q3SZJ4 |
| UniProtKB/Swiss-Prot Entry Name
| PTGR1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC102822 |
| GeneCard ID
| PTGR1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
