| Identification |
|---|
| BMDB Protein ID
| BMDBP01048 |
| Secondary Accession Numbers
| None |
| Name
| Ubiquitin carboxyl-terminal hydrolase 20 |
| Synonyms
|
Not Available
|
| Gene Name
| USP20 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in cysteine-type peptidase activity |
| Specific Function
| Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| Not Available |
| SNPs
| USP20 |
| Gene Sequence
|
>2739 bp
ATGGGGGACTCCAGGGACCTTTGTCCTCATCTTGACTCGATAGGGGAGGTGACCAAAGAG
GACTTGCTGCTCAAATCCAAGAGCACCTGTCAGTCATGCGGGGTTTCTGGACCCAACCTG
TGGGCCTGTCTCCAGGTCTCCTGCTCCTACGTTGGCTGCGGAGAATCCTTCGCTGACCAC
AGCACCCTGCACGCACAGGCGAAAAAGCACAACCTGACGGTGAACCTGACCACGTTCCGG
GTGTGGTGCTACGCCTGTGAGAAGGAAGTGTTCCTGGAGCCGCGCCTGGCGGCCCACCCG
CCTGGCCCCGCGCCCAAGTTCTCAGAGCAGGACTCTCCGCCACCCTCCCACCCTCTGAAA
GCCGTCCCCATCGCTGTGGCGGACGAAGGAGAGTCCGAGTCGGAGGACGACGACCTGAAG
CCACGAGGCCTCACGGGCATGAAGAACCTCGGCAACTCCTGCTACATGAATGCGGCCTTG
CAGGCTCTGTCCAACTGCCCCCCGCTCACCCAGTTCTTCTTGGAGTGTGGAGGCCTGGTC
CGCACAGACAAGAAGCCAGCCCTGTGCAAAAGTTATCAGAAGCTGGTCTCTGAGGTCTGG
CACAGGAAACGCCCCAGCTATGTGGTTCCCACCAGCCTGTCCCATGGGATCAAGTTGGTC
AACCCAATGTTCCGAGGCTATGCCCAGCAGGACACCCAGGAATTCTTGCGCTGCCTGATG
GACCAGCTGCACGAGGAACTCAAGGAGCCCGTGGTGGCCACAGCGGCGGCGCTGACCGAG
GCGCGGGACTCGGACTCGAGCGACACGGATGAGAAGCGGGAGGGTGACCGGAGCCCCTCA
GAGGACGAGTTCCTGTCCTGCGACTCCAGCAGCGACCGCGGCGAGGGCGACGGGCAGGGG
CGCAGCGGGGGAGGCTCCCAGGCCGAGGCGGAGCTGCTGATGGCGGACGAGGCGGGCCGC
GCCATCTCCGAGAAGGAGCGCATGAAGGACCGCAAGTTCTCGTGGGGCCAGCAGCGCACC
AACTCGGAGCAGGTGGACGAGGACGCCGACGTGGACACCGCCATGGCCGCCCTGGAGCAG
CAGCCCCCGGAGACGCAGCCCCCCTCCCCGCGGTCCACCAGTCCCTGCCGGACGCCAGAG
CCGGACAACGAGGCGCACATGCGCAGCTCCCGGCCCTGCAGCCCCGTCCACCACCACGAA
GGCCACGCCAAGCTGGCCAGCAGCCCTCATCGTGCGAGCCCTGTGAGGATGGGGCCGGCC
TATGTGCTCAAGAAAGCCCAGGTCCCCGGCAGCCGGCGGCGGAAGGAGCAGAGCTACCGC
AGCGTCATCTCGGACATCTTCGACGGCTCCGTCCTCAGCCTCGTGCAGTGTCTCACCTGT
GACCGGGTGTCCACCACTGTGGAGACATTCCAGGACCTGTCACTGCCCATTCCTGGCAAG
GAGGACCTGGCCAAACTCCACTCGGCCATCTACCAGAACGTGCCGGCCAAGCCGGGTGCC
TGCGGGGACAGCTATGTGGCCCAGGGCTGGCTTGCCTTTATTGTGGAGTATATCCGACGG
TTCGTGGTGTCCTGTACCCCTAGCTGGTTTTGGGGGCCAGTCGTCACCCTGGAAGACTGC
CTGGCTGCCTTCTTTGCTGCTGATGAGCTGAAGGGTGACAACATGTACAGCTGTGAACGG
TGTAAAAAGCTGCGCAACGGGGTGAAGTACTGTAAGGTCTTGCGGTTGCCGGAGATCCTG
TGCATTCACCTGAAGCGCTTTAGGCACGAGGTCATGTACTCTTTCAAGATCAGCAGCCAT
GTGTCCTTCCCCCTCGAGGGCCTTGACCTGCGCCCCTTCCTCGCCAAGGAGTGCACGTCC
CAGATCACCACCTATGACCTCCTCTCGGTCATCTGCCACCACGGCACGGCAGGCAGTGGC
CACTACATCGCCTACTGCCAGAACGTGATCAACGGGCAGTGGTATGAGTTCGACGACCAG
TACGTCACCGAGGTCCACGAGACGGTGGTGCAGAACGCGGAGGCCTACGTGCTCTTCTAC
AGGAAGAGCAGCGAGGAAGCTGTGCGGGAGCGACAGCAGGTGGTGTCCCTGGCCGCCATG
CGGGAGCCCAGCCTGCTGCGGTTCTACGTGTCCCGGGAATGGCTCAACAAGTTTAACACC
TTCGCGGAGCCAGGGCCCATCACCAACCACACGTTCCTCTGCTCCCACGGAGGGATCCCG
CCCAACAAATATCACTACATCGATGACCTGGTGGTGATCCTGCCGCAGAACGTGTGGGAG
CACCTCTACAGCAGGTTTGGGGGCGGCCCCGCTGTGAACCATCTGTACGTGTGCTCCATC
TGCCAGGTGGAGATCGAGGCTCTGGCCAAGCGCAGGCGGGTGGAGATCGACACCTTCATC
AAGCTGAACAAGGCGTTCCAGGCCGAGGAGTCGCCCAGCGTCATCTACTGTATCAGCATG
CAGTGGTTCCGAGAGTGGGAGGCCTTCGTCAAGGGCAAGGACAACGAGCCCCCGGGGCCC
ATTGACAACAGCAGGATCGCACAGGTCAAAGGAAGCGGCCACATCCAGCTGAAGCCGGGA
GCTGACTATGGGCAGATCTCCGAGGAGACCTGGGTGTACCTGAACAACCTCTATGGCGGC
GGCCCCGAGATTGCCATCCGCCAGAGCGTGGCTCAGCTCCCGGACCCGGAGAGCTTGCAC
GGTGAACAGAAGATTGAAGCCGAGACCCGGGCCTTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 912 |
| Molecular Weight
| 101815.0 |
| Theoretical pI
| 6.06 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Ubiquitin carboxyl-terminal hydrolase
MGDSRDLCPHLDSIGEVTKEDLLLKSKSTCQSCGVSGPNLWACLQVSCSYVGCGESFADH
STLHAQAKKHNLTVNLTTFRVWCYACEKEVFLEPRLAAHPPGPAPKFSEQDSPPPSHPLK
AVPIAVADEGESESEDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLV
RTDKKPALCKSYQKLVSEVWHRKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLM
DQLHEELKEPVVATAAALTEARDSDSSDTDEKREGDRSPSEDEFLSCDSSSDRGEGDGQG
RSGGGSQAEAELLMADEAGRAISEKERMKDRKFSWGQQRTNSEQVDEDADVDTAMAALEQ
QPPETQPPSPRSTSPCRTPEPDNEAHMRSSRPCSPVHHHEGHAKLASSPHRASPVRMGPA
YVLKKAQVPGSRRRKEQSYRSVISDIFDGSVLSLVQCLTCDRVSTTVETFQDLSLPIPGK
EDLAKLHSAIYQNVPAKPGACGDSYVAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLEDC
LAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKISSH
VSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFDDQ
YVTEVHETVVQNAEAYVLFYRKSSEEAVRERQQVVSLAAMREPSLLRFYVSREWLNKFNT
FAEPGPITNHTFLCSHGGIPPNKYHYIDDLVVILPQNVWEHLYSRFGGGPAVNHLYVCSI
CQVEIEALAKRRRVEIDTFIKLNKAFQAEESPSVIYCISMQWFREWEAFVKGKDNEPPGP
IDNSRIAQVKGSGHIQLKPGADYGQISEETWVYLNNLYGGGPEIAIRQSVAQLPDPESLH
GEQKIEAETRAL
|
| External Links |
|---|
| GenBank ID Protein
| AAI53255.1 |
| UniProtKB/Swiss-Prot ID
| A7Z056 |
| UniProtKB/Swiss-Prot Entry Name
| UBP20_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC153254 |
| GeneCard ID
| USP20 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
