| Identification |
|---|
| BMDB Protein ID
| BMDBP01050 |
| Secondary Accession Numbers
| None |
| Name
| AFG3-like protein 2 |
| Synonyms
|
Not Available
|
| Gene Name
| AFG3L2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Posttranslational modification, protein turnover, chaperones |
| Specific Function
| ATP-dependent protease which is essential for axonal and neuron development. In neurons, mediates degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU. Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form. Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 24 |
| Locus
| Not Available |
| SNPs
| AFG3L2 |
| Gene Sequence
|
>2418 bp
ATGGCGCACCGCTGCTTGCTGCTATGGGGCCGGGGCGCCTGCCGGCCCCGCGGGATGCCC
CCGATGCTCTTGCCTGGCGGCCGCACGGGCTCCACCGAACGGCTCTACCTGCGGATGCTT
TATCGATATGCCACGACTCAGGCGAAAACCAGCAGGAATTCCCTTCTGACAGATGTGATT
GCTGCTTATCAGAGACTCTGTTCTCGGCCTCCAAAAGGATTTGAAAAATACTTTCCCAAT
GGAAAAAATGGAAAAAAAACTAGTGAACCTAAAGAAGTTATGGGAGAAAAAAAAGAACCC
AAGCCAGCTGCTGCCCCGCGTCCTTCTGGAGGAGGAGTTGGTGGCGGTGGAAAACGAGGC
GGCAAGAAAGATGACTCTCACTGGTGGTCCAGGTTCCAGAAGGGTGACATCCCATGGGAT
GATAAGGAATTCAAGATGTACTTTCTCTGGACCGCCCTGTTTTGGGGAGGATTCCTGTTT
TACTTCCTGTTCAAGAGCTCCGGGAGAGAAATCACGTGGAAGGACTTTGCTAACAACTAT
CTTTCCAAGGGAGTTGTAGACAGACTGGAAGTTGTCAACAAGCGATTTGTTCGAGTGACT
TTTACACCAGGAAAAACTCCTGTTGATGGACAGTACGTCTGGTTCAATATTGGCAGTGTG
GACACCTTTGAGCGGAACCTGGAGACGCTGCAGCAGGAACTAGGCATAGAAGGAGAGAAC
CGGGTCCCTGTGGTCTACATCGCCGAGAGTGACGGCTCCTTCCTCCTGAGCATGCTGCCC
ACCGTGCTCATCATCGCCTTCCTGCTCTACACCATCCGGAGGGGCCCAGCCGGCATCGGC
CGCACAGGCCGGGGCATGGGCGGACTCTTCAGTGTTGGAGAGACCACCGCCAAGGTCCTC
AAGGATGAGATTGACGTGAAGTTCAAAGACGTGGCCGGCTGTGAGGAGGCCAAGCTGGAG
ATCATGGAATTTGTGAATTTCCTAAAAAATCCAAAGCAGTATCAAGACCTGGGAGCAAAA
ATCCCAAAGGGTGCCATTCTCACTGGTCCTCCAGGCACTGGGAAGACACTGCTGGCTAAG
GCCACGGCTGGAGAAGCCAATGTCCCTTTCATCACCGTTAGCGGGTCTGAGTTCTTGGAG
ATGTTTGTTGGTGTAGGCCCAGCTAGAGTCCGTGACTTATTCGCTCTTGCTCGGAAGAAC
GCCCCTTGCATCCTCTTCATCGATGAAATAGATGCGGTGGGAAGGAAGAGAGGCAGGGGC
AACTTCGGCGGGCAGAGTGAGCAGGAGAACACGCTCAACCAGCTGCTTGTGGAGATGGAC
GGATTTAACACAACAACCAATGTGGTCATCTTGGCGGGCACCAACCGACCGGATATCCTA
GACCCAGCTCTGATGAGGCCAGGCCGCTTCGACAGGCAGATCTTCATTGGACCGCCGGAC
ATTAAGGGAAGAGCCTCTATTTTCAAAGTTCATCTCCGACCCCTGAAGCTGGATAGCACC
CTGGAAAAGGAGAAGCTGGCGAGGAAGCTCGCATCCTTGACCCCGGGGTTTTCAGGAGCC
GATGTTGCCAACGTGTGCAACGAAGCTGCTTTGATCGCTGCGAGACACCTTTCAGATTCC
ATAAACCAGAAACACTTTGAACAAGCAATTGAACGAGTGATTGGCGGCTTAGAGAAGAAA
ACGCAGGTCCTACAGCCTGAGGAGAAGAAGACAGTGGCATACCATGAGGCAGGCCACGCA
GTTGCCGGTTGGTACCTGGAGCACGCAGACCCCCTCTTGAAGGTGTCCATCATCCCACGA
GGCAAAGGGCTGGGCTACGCTCAGTACCTGCCCCGGGAGCAGTACCTCTACACCCGGGAG
CAGCTCCTGGACCGCATGTGCATGACCTTGGGCGGCCGCGTGTCCGAGGAGATCTTCTTT
GGCAGGATCACTACCGGTGCCCAGGACGACTTGCGCAAAGTGACCCAGAGTGCCTACGCC
CAGATTGTTCAGTTTGGCATGAACGAGAAGGTCGGGCAGATCTCCTTTGACCTCCCACGT
CAGGGGGACATGGTGTTGGAGAAGCCGTACAGCGAGGCCACCGCCAGACTCATAGATGAC
GAAGTACGAATCCTTATCAACGATGCTTACAAGAGGACAGTGGCCCTCCTCACAGAGAAG
AAAGCTGACGTGGAGAAGGTTGCTCTGCTGTTGTTAGAAAAAGAAGTGTTAGACAAGAAC
GACATGGTGGAACTTCTGGGCCCCAGGCCATTTGCGGAGAAGTCTACGTACGAGGAGTTT
GTGGAAGGCACTGGTAGCCTAGACGAGGACACCTCACTCCCCGAGGGCCTGAAGGACTGG
AACAGGGAGCGTGAGGGCTCAGAGGAGCCCTCGGGCGAGAAGGTGACCAGCCCGGTCCAG
GGTGCCGGCCCTGCGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 805 |
| Molecular Weight
| 89388.0 |
| Theoretical pI
| 9.05 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>AFG3-like protein 2
MAHRCLLLWGRGACRPRGMPPMLLPGGRTGSTERLYLRMLYRYATTQAKTSRNSLLTDVI
AAYQRLCSRPPKGFEKYFPNGKNGKKTSEPKEVMGEKKEPKPAAAPRPSGGGVGGGGKRG
GKKDDSHWWSRFQKGDIPWDDKEFKMYFLWTALFWGGFLFYFLFKSSGREITWKDFANNY
LSKGVVDRLEVVNKRFVRVTFTPGKTPVDGQYVWFNIGSVDTFERNLETLQQELGIEGEN
RVPVVYIAESDGSFLLSMLPTVLIIAFLLYTIRRGPAGIGRTGRGMGGLFSVGETTAKVL
KDEIDVKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAK
ATAGEANVPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKRGRG
NFGGQSEQENTLNQLLVEMDGFNTTTNVVILAGTNRPDILDPALMRPGRFDRQIFIGPPD
IKGRASIFKVHLRPLKLDSTLEKEKLARKLASLTPGFSGADVANVCNEAALIAARHLSDS
INQKHFEQAIERVIGGLEKKTQVLQPEEKKTVAYHEAGHAVAGWYLEHADPLLKVSIIPR
GKGLGYAQYLPREQYLYTREQLLDRMCMTLGGRVSEEIFFGRITTGAQDDLRKVTQSAYA
QIVQFGMNEKVGQISFDLPRQGDMVLEKPYSEATARLIDDEVRILINDAYKRTVALLTEK
KADVEKVALLLLEKEVLDKNDMVELLGPRPFAEKSTYEEFVEGTGSLDEDTSLPEGLKDW
NREREGSEEPSGEKVTSPVQGAGPA
|
| External Links |
|---|
| GenBank ID Protein
| AAI05323.1 |
| UniProtKB/Swiss-Prot ID
| Q2KJI7 |
| UniProtKB/Swiss-Prot Entry Name
| AFG32_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC105322 |
| GeneCard ID
| AFG3L2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
