1.0 2018-05-07 22:25:14 UTC 2020-05-20 21:11:22 UTC BMDBP01059 Enzyme APTX Nucleotide transport and metabolism DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity). BMDB0001303 Zinc 8 >1071 bp ATGAGTAACGTGAGCTTGTCGGCCTCAGCCGTCTCGAGAGTAATGATGCGGGTGTGCTGG TTGGTGAGACAGGACAACCGGCACCAGCGAATCAAACTTCCACATTTGGAAACAGTCATG GTTGGGCGCAGCCCAGAGACCAAGATCGCCGACAAGAAGTGTTCTCGACAGCAAGTACAG TTGAAAGCAGAGTGTAACAAAGGATATGTCAAGGTAAAGCAGGTAGGGGTCAATCCCACC AGCATTGACTCAGTCATAATTGGGAAGGACCAGGAGGTGAAGCTGCAGCCTGGCCAGGTC CTCTACCTGGTGAATGAACTTTATCCGTATATTATAGAGTTTGAGGAAGAGACAAAGAGC CCTGGCCTGGAGTCACACAGGAAGAGAAAGAGGTCAGGCAGTAGCGATCCTACAGAAAGG GGTGCTGACCCGGAAGCTGAGCCCAGCACAGGACTGGAACCTGGGAGCAACCCTCACCAG TGCTCTGTGCCTCCAAAGAAGGAGAAGGATGCATCCATCAAAAAGGAATCCTTGGGCCAC TGGAGTCAAGGCTTGAAGATTTCTATGGAGGACCCCAAAATGCAGGTTTACAAAGATGAG CAGGTGGTGGTGATAAAGGATAAATACCCCAAGGCTCGTTTCCACTGGCTGGTCTTACCT TGGGCCTCCATTTCCAGTCTGAAGGCTGTGACCAGAGAACATCTTGAGCTCCTCAGACAC ATGCACGCTGTTGGAGAGAAAGTGATTGCTGACTTCGCTGGGTCCAGCAAATTCCGCTTC CGATTGGGCTACCATGCCATTCCCAGCATGAGCCATGTACACCTCCATGTGATCAGCCAG GATTTTGATTCTCCTTGCCTTAAAAACAAAAAACACTGGAATTCTTTCAATACTGAGTAC TTCCTTGAATCACAAGCTGTGATTGAGATGGTGCAAGAGGCTGGCAGGGTGACCGTCCGA GACGGGATGCCCGAGCTCCTGAAGCTGCCCCTCCGTTGTCACGAGTGCCAGCAGCTGCTG CCTTCCATCCCTCAGCTGAAGGAGCACCTCAGGAAGCACTGGTCCAAGTGA 356 40659.0 9.67 None >Aprataxin MSNVSLSASAVSRVMMRVCWLVRQDNRHQRIKLPHLETVMVGRSPETKIADKKCSRQQVQ LKAECNKGYVKVKQVGVNPTSIDSVIIGKDQEVKLQPGQVLYLVNELYPYIIEFEEETKS PGLESHRKRKRSGSSDPTERGADPEAEPSTGLEPGSNPHQCSVPPKKEKDASIKKESLGH WSQGLKISMEDPKMQVYKDEQVVVIKDKYPKARFHWLVLPWASISSLKAVTREHLELLRH MHAVGEKVIADFAGSSKFRFRLGYHAIPSMSHVHLHVISQDFDSPCLKNKKHWNSFNTEY FLESQAVIEMVQEAGRVTVRDGMPELLKLPLRCHECQQLLPSIPQLKEHLRKHWSK AAK91769.1 Q7YRZ2 APTX_BOVIN AY040778 APTX