| Identification |
|---|
| BMDB Protein ID
| BMDBP01065 |
| Secondary Accession Numbers
| None |
| Name
| Ubiquitin carboxyl-terminal hydrolase 33 |
| Synonyms
|
Not Available
|
| Gene Name
| USP33 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in cysteine-type peptidase activity |
| Specific Function
| Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| USP33 |
| Gene Sequence
|
>2739 bp
ATGTCATCTTTTCGAAGTCATTGTCCACATTTGGATTCAGTTGGTGAAATAACTAAAGAA
GATTTAATACAAAAATCTCATGGTTCTTGTCAGGATTGTAAAGTCAGAGGACCAAACCTT
TGGGCATGCCTGGAGAATAGGTGTTCATATGTTGGCTGTGGTGAATCACAAGTGGATCAT
AGCACCATACATTCTCAGGAGACAAAGCATTATCTAACTGTGAACCTTACCACCCTTCGA
GTTTGGTGTTATGCTTGCAGCAAAGAAGTATTTTTGGATAGGAAATTAGGAACTCAGCCT
TCATTACCTCATGTAAAACCACTTCACCAAATACAAGAAAATGGCGTACAGGATTTTAAA
ATACCCAGTAACACAACATTAAAAACTCCTCTGGTTGCTGTGTTTGATGATCTGGATATA
GAAGTAGAAGAAGAAGATGAACTTAAGGCAAGAGGTCTTACAGGTTTGAAAAATATTGGA
AATACTTGTTATATGAATGCAGCTTTGCAGGCTCTTTCTAACTGCCCGCCTTTGACGCAG
TTTTTTCTTGATTGTGGAGGACTGGCTCGAACAGATAAGAAACCAGCTATTTGTAAAAGT
TATCTCAAACTGATGACAGAGCTCTGGCATAAAAGCAGGCCAGGATCAGTTGTGCCTACT
ACTCTGTTTCAAGGAATTAAAACTGTAAATCCAACATTTCGGGGGTATTCTCAGCAGGAT
GCTCAAGAATTCCTTCGATGTTTAATGGATCTGCTTCATGAAGAATTGAAAGAACAAGTC
ATGGAAGTAGAAGAGGATCCTCAAACTATAATGACTGAAGAGACCATGGAGGAAGACAAG
AGCCAGTCAGATGTAGATTTTCAGTCCTGCGAATCTTGTAGCAGCAGTGATAAAGCTGAA
AATGAAAATGGCTCTAGAAGCTTTTCTGAAGATAATAATGAGACAACAATGTTAATTCAG
GATGATGAGAACAATTCAGAAATGTCAAAAGATTGGCAAAAAGAGAAGATGTGCAACAAG
ATTAATAAAGTACATTCTGAAGGAGAATTAGATAAAGATAGAGACTCTGTATCTGAAACA
GCTGATTTGAACAACCAGGAAACTGTCAAAGTGCAAATACACAGCAGAGCTTCAGAATAT
ATTACTGATGTCCATTTGAATGACCTGTCTACACCACAGATCCTCCCATCAAATGAAGGT
GTTAATCCAAGATTATCAGCAAGCCCTCCTAAATCAGGCAATTTGTGGCCAGGATTGCCA
CCCACACACAAAAAAGTTCAATCTGCATTATCTCCAAAGAGAAAAAAACAGCACAAGAAA
TACCGAAGTGTTATTTCAGACATATTTGATGGAACAATCATTAGTTCAGTTCAGTGTCTG
ACTTGTGACAGGGTGTCTGTAACCCTCGAGACCTTTCAAGATCTGTCCTTGCCAATTCCT
GGCAAGGAAGACCTTGCTAAACTGCATTCGTCAAGTCATCCAACATCTATAGTCAAAGCA
GGATCATGTGGCGAAGCATATGCTCCACAAGGGTGGATAGCTTTTTTCATGGAGTATGTG
AAGAGGTTTGTTGTCTCATGTGTCCCTAGCTGGTTTTGGGGTCCAGTAGTAACCTTGCAA
GATTGTCTTGCTGCCTTCTTTGCCAGAGATGAACTAAAAGGTGACAATATGTACAGTTGT
GAAAAATGCAAAAAGTTGAGAAATGGAGTAAAGTTTTGTAAAGTACAAAAGTTTCCTGAG
ATTTTGTGCATCCATCTTAAAAGATTCAGACATGAACTGATGTTTTCCACCAAAATCAGT
ACCCATGTTTCATTTCCACTGGAAGGCCTGGATCTTCAACCATTTCTTGCTAAAGATAGT
CCGGTGCAAATTGTTACCTATGATCTTCTGTCAGTCATTTGTCACCATGGAACTGCAAGT
AGTGGACACTATATTGCCTACTGCCGAAACAATTTAAATAATCTCTGGTATGAATTTGAC
GACCAGAGTGTCACTGAAGTTTCAGAGTCTACTGTACAAAATGCAGAAGCTTATGTTCTC
TTCTACAGGAAGAGCAGTGAAGAAGCACAAAAAGAGAGGCGAAGAATATCAAATTTGTTG
AACATAATGGAACCAAGTCTCCTTCAGTTTTATATTTCTCGACAGTGGCTAAATAAATTT
AAGACCTTTGCTGAACCTGGCCCTATTTCAAATAATGATTTTCTCTGTATTCATGGAGGT
GTTCCTCCACGAAAAGCTGGTTATATTGAAGACCTGGTTTTGATGCTGCCTCAGAACATT
TGGGATAACCTATATAGCAGGTATGGAGGAGGACCAGCCGTCAACCATCTGTACATTTGT
CACACTTGCCAGATTGAAGCGGAGAAAATTGAAAAAAGAAGAAAAACTGAATTGGAAATT
TTTATTCGGCTCAACAGAGCATTCCAAGAGGAAGACTCTCCAGCTACTTTTTATTGCATC
AGTATGCAATGGTTTAGAGAATGGGAAAGTTTTGTGAAGGGTAAAGATGGAGATCCTCCA
GGTCCTATTGATAACACTAAAATTGCAGTCACCAAATGTGGCAATGTGATACTCAGGCAA
GGAGCAGATTCTGGTCAGATTTCTGAAGAAACATGGAATTTTCTACAGTCTATATATGGT
GGAGGGCCCGAAGTTATCTTGCGGCCTCCAGTTGTTCATGTTGATCCTGATGCAGTACAA
GCAGAAGAAAAAATTGAAGTAGAAACTCGGTCTTTGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 912 |
| Molecular Weight
| 103323.0 |
| Theoretical pI
| 5.76 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Ubiquitin carboxyl-terminal hydrolase
MSSFRSHCPHLDSVGEITKEDLIQKSHGSCQDCKVRGPNLWACLENRCSYVGCGESQVDH
STIHSQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVKPLHQIQENGVQDFK
IPSNTTLKTPLVAVFDDLDIEVEEEDELKARGLTGLKNIGNTCYMNAALQALSNCPPLTQ
FFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQD
AQEFLRCLMDLLHEELKEQVMEVEEDPQTIMTEETMEEDKSQSDVDFQSCESCSSSDKAE
NENGSRSFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVHSEGELDKDRDSVSET
ADLNNQETVKVQIHSRASEYITDVHLNDLSTPQILPSNEGVNPRLSASPPKSGNLWPGLP
PTHKKVQSALSPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIP
GKEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQ
DCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQKFPEILCIHLKRFRHELMFSTKIS
THVSFPLEGLDLQPFLAKDSPVQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFD
DQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKF
KTFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSRYGGGPAVNHLYIC
HTCQIEAEKIEKRRKTELEIFIRLNRAFQEEDSPATFYCISMQWFREWESFVKGKDGDPP
GPIDNTKIAVTKCGNVILRQGADSGQISEETWNFLQSIYGGGPEVILRPPVVHVDPDAVQ
AEEKIEVETRSL
|
| External Links |
|---|
| GenBank ID Protein
| AAI48906.1 |
| UniProtKB/Swiss-Prot ID
| A6QNM7 |
| UniProtKB/Swiss-Prot Entry Name
| UBP33_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC148905 |
| GeneCard ID
| USP33 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
