| Identification |
|---|
| BMDB Protein ID
| BMDBP01073 |
| Secondary Accession Numbers
| None |
| Name
| 2-oxoglutarate dehydrogenase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| OGDH |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| 2-oxoglutarate dehydrogenase (E1) component of the 2-oxoglutarate dehydrogenase complex, which mediates the decarboxylation of alpha-ketoglutarate. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. |
| Pathways
|
- Citric Acid Cycle
- Lysine Degradation
- Warburg Effect
|
| Reactions
|
| Oxoadipic acid + Coenzyme A → Glutaryl-CoA + Carbon dioxide |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| Not Available |
| SNPs
| OGDH |
| Gene Sequence
|
>3072 bp
ATGTTTCACTTAAGGACTTGTGCTGCTAAGTTGAGGCCGTTAACGGCTTCCCAGACTGTG
AAGACATTTTCACAAAACAGACCAGCAGCAGCTAGGACGTTTGGGCAGATACGGTGCTAT
ACTGCCCCCGTTGCTGCAGAGCCTTTCCTCAGCGGGACTAGTTCGAACTATGTGGAGGAA
ATGTACTATGCTTGGTTGGAAAACCCCAAAAGTGTACACAAGTCATGGGACATTTTTTTC
CGAAACACCAATGCTGGAGCGCCCCCAGGCACCGCCTACCAGAGCCCACTCCCCCTGAGC
CCGGGCTCCCTGTCAGCTGTGGCCAGAGCAGGGCCCCTGGTGGAGGCCCAGCCCAACGTG
GACAAGCTGGTGGAGGATCACCTGGCGGTGCAGTCGCTCATCAGGGCTTACCAGATACGA
GGGCACCATGTAGCACAGCTGGACCCCCTGGGAATTTTGGATGCTGATCTGGACTCCTCC
GTGCCCGCTGATATTATCTCATCCACAGACAAACTTGGATTCTACGGTCTGGACGAGTCT
GACCTGGACAAGGTCTTCCACCTGCCCACCACCACATTCATTGGAGGGCAGGAGTCGGCT
CTTCCTCTGCGGGAAATCATCCGACGCCTGGAGATGGCCTACTGCCAGCACATTGGGGTA
GAATTCATGTTCATCAATGACCTGGAGCAGTGCCAGTGGATCCGGCAGAAATTTGAGACA
CCCGGGGTCATGCAGTTCACCAACGAGGAGAAGCGGACCCTGCTGGCTCGGCTCGTGCGC
TCCACCAGGTTTGAGGAGTTCCTGCAGCGGAAGTGGTCATCTGAGAAGCGCTTTGGTCTG
GAAGGCTGCGAAGTACTGATTCCTGCCCTCAAGACCATCATTGACAAGTCCAGTGAGAAC
GGAGTGGACTACGTGATCATGGGAATGCCACACAGGGGGAGACTGAATGTGCTTGCAAAC
GTCATCAGGAAGGAGCTGGAGCAAATTTTCTGTCAGTTCGACTCAAAGCTGGAGGCAGCT
GATGAGGGTTCTGGAGATGTGAAGTACCACCTGGGCATGTATCACCGGCGGATCAACCGT
GTGACCGACAGGAATATCACCCTGTCGCTGGTGGCAAACCCTTCCCACCTGGAGGCTGCC
GATCCCGTGGTGATGGGCAAGACCAAAGCTGAGCAGTTTTACTGCGGGGACACCGAGGGG
AAGAAGGTCATGTCCATCCTTCTGCATGGGGACGCCGCATTTGCTGGCCAGGGCATCGTT
TATGAGACCTTCCACCTGAGTGACCTGCCATCTTACACGACTCATGGCACTGTCCACGTG
GTTGTCAACAACCAGATCGGCTTCACCACAGACCCGCGAATGGCCCGCTCCTCACCCTAC
CCCACTGATGTGGCCCGAGTGGTGAATGCCCCTATCTTCCACGTGAACTCGGATGACCCG
GAGGCAGTCATGTATGTGTGCAAAGTTGCAGCTGAGTGGAGGAGCACCTTCCACAAGGAT
GTGGTGGTGGACCTGGTGTGTTATCGGCGCAATGGCCACAACGAGATGGATGAGCCCATG
TTCACCCAGCCGCTGATGTACAAGCAGATCCGCAAACAGAAGCCCGTGCTGCAGAAGTAC
GCAGAGTTGCTGGTGTCGCAGGGCGTGGTCAACCAGCCTGAGTATGAGGAGGAGATCTCC
AAATATGACAAGATCTGTGAGGAGGCCTTCGCCAGGTCCAAGGACGAAAAGATCTTGCAC
ATCAAGCACTGGCTGGACTCCCCCTGGCCTGGCTTCTTCACCCTGGACGGGCAGCCGAGG
AGCATGACCTGCCCCTCCACGGGCCTGACGGAGGACATTCTCACACACATTGGGAACGTG
GCCAGCTCCGTGCCTGTGGAGGATTTCACCATTCACGGAGGGCTGAGCCGGATCCTGAAG
ACCCGTGGGGAGCTGGTGAAGAACAGGACTGTGGACTGGGCTCTGGCGGAGTACATGGCT
TTTGGCTCCCTACTGAAGGAGGGCATCCATATCCGGCTGAGCGGCCAGGATGTGGAGCGG
GGCACTTTTAGCCATCGCCACCACGTCCTGCATGACCAGAACGTGGACAAGAGAACCTGC
ATCCCCATGAACCACCTCTGGCCCAACCAGGCCCCCTACACCGTGTGCAACAGCTCACTG
TCCGAGTACGGGGTCCTGGGCTTCGAGCTGGGTTTTGCAATGGCCAGTCCTAACGCCCTG
GTCCTCTGGGAGGCCCAGTTTGGTGACTTCCATAACACGGCCCAGTGCATCATCGACCAG
TTCATCTGCCCAGGACAAGCCAAGTGGGTGCGGCAGAACGGCATTGTGCTGCTGCTGCCC
CATGGCATGGAGGGCATGGGCCCAGAACATTCCTCCGCCAGGCCAGAGAGGTTCCTGCAG
ATGTGCAATGATGATCCAGACGTCCTACCGGACCTTAAGGAAGCCAACTTTGACATAAAT
CAGCTGTATGATTGCAACTGGGTTGTCGTCAACTGCTCCACCCCTGGCAACTTCTTCCAC
GTGCTACGTCGCCAGATTCTCCTGCCCTTCCGGAAGCCGTTAATCATCTTCACCCCAAAG
TCCCTGCTGCGGCATCCCGAAGCCAGGTCCAACTTTGACGAGATGCTTCCAGGAACCCAC
TTCCAGCGGGTGATCCCAGAAGATGGCCCTGCAGCACAGAACCCAGGAAACGTCAAGAGA
CTTCTCTTCTGTACTGGCAAGGTGTACTATGACCTCACCCGAGAGCGCAAAGCGCGGGAC
ATGGTGGAGCAGGTGGCCATCACCAGGATCGAGCAGCTGTCGCCTTTCCCCTTCGACCTC
CTGCTGCAGGAGGTCCAGAAGTACCCCAGCGCTGAGCTGGCCTGGTGCCAGGAGGAGCAC
AAGAACCAAGGCTACTACGACTACGTGAAGCCCAGGCTGCGAACCACCATCAGCCGCGCC
AAGCCTGTGTGGTATGCTGGCCGGGACCCAGCAGCAGCTCCAGCCACCGGCAACAAGAAG
ACCCACCTCACGGAGCTGCAGCGCCTCCTGGACACAGCCTTCGACCTGGACGCCTTCAAG
AACTTCTCGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1023 |
| Molecular Weight
| 115808.0 |
| Theoretical pI
| 6.74 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>2-oxoglutarate dehydrogenase E1 component, mitochondrial
MFHLRTCAAKLRPLTASQTVKTFSQNRPAAARTFGQIRCYTAPVAAEPFLSGTSSNYVEE
MYYAWLENPKSVHKSWDIFFRNTNAGAPPGTAYQSPLPLSPGSLSAVARAGPLVEAQPNV
DKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADIISSTDKLGFYGLDES
DLDKVFHLPTTTFIGGQESALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIRQKFET
PGVMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIIDKSSEN
GVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGSGDVKYHLGMYHRRINR
VTDRNITLSLVANPSHLEAADPVVMGKTKAEQFYCGDTEGKKVMSILLHGDAAFAGQGIV
YETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNSDDP
EAVMYVCKVAAEWRSTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKPVLQKY
AELLVSQGVVNQPEYEEEISKYDKICEEAFARSKDEKILHIKHWLDSPWPGFFTLDGQPR
SMTCPSTGLTEDILTHIGNVASSVPVEDFTIHGGLSRILKTRGELVKNRTVDWALAEYMA
FGSLLKEGIHIRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPYTVCNSSL
SEYGVLGFELGFAMASPNALVLWEAQFGDFHNTAQCIIDQFICPGQAKWVRQNGIVLLLP
HGMEGMGPEHSSARPERFLQMCNDDPDVLPDLKEANFDINQLYDCNWVVVNCSTPGNFFH
VLRRQILLPFRKPLIIFTPKSLLRHPEARSNFDEMLPGTHFQRVIPEDGPAAQNPGNVKR
LLFCTGKVYYDLTRERKARDMVEQVAITRIEQLSPFPFDLLLQEVQKYPSAELAWCQEEH
KNQGYYDYVKPRLRTTISRAKPVWYAGRDPAAAPATGNKKTHLTELQRLLDTAFDLDAFK
NFS
|
| External Links |
|---|
| GenBank ID Protein
| AAI18107.1 |
| UniProtKB/Swiss-Prot ID
| Q148N0 |
| UniProtKB/Swiss-Prot Entry Name
| ODO1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC118106 |
| GeneCard ID
| OGDH |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
