| Identification |
|---|
| BMDB Protein ID
| BMDBP01090 |
| Secondary Accession Numbers
| None |
| Name
| Cyclin-dependent kinase 5 activator 1 |
| Synonyms
|
Not Available
|
| Gene Name
| CDK5R1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in cadherin binding |
| Specific Function
| p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| CDK5R1 |
| Gene Sequence
|
>924 bp
ATGGGCACGGTGCTGTCCCTGTCCCCCAGCTACCGGAAGGCCACGCTGTTTGAGGATGGC
GCGGCCACGGTGGGCCACTACACGGCCGTGCAGAACAGCAAGAACGCCAAGGACAAGAAC
CTGAAGCGGCACTCCATCATCTCCGTGCTGCCGTGGAAGAGGATCGTGGCCGTGTCGGCC
AAGAAGAAGAACTCCAAGAAGGTGCAGCCCAACAGCAGCTATCAGAACAACATCACGCAC
CTCAACAATGAGAACCTGAAGAAGTCGCTGTCGTGCGCCAACCTGTCCACGTTCGCCCAG
CCCCCGCCGGCCCAGCCGCCCGCCCCCCCTGCCAGCCAGCTCTCGGGTTCGCAGACCGGG
GTCTCCTCGTCCGTCAAGAAGGCCCCGCACCCTGCCGTCAGCTCCGCAGGAACGCCCAAA
CGGGTCATCGTCCAGGCGTCCACCAGCGAGCTGCTGCGCTGCCTGGGCGAGTTCCTCTGT
CGCCGGTGCTACCGCCTGAAGCACCTGTCCCCCACGGACCCTGTGCTCTGCGTGCGCAGC
GTGGACCGCTCGCTGCTGCTGCAGGGCTGGCAGGACCAGGGCTTCATCACGCCGGCCAAC
GTGGTCTTCCTCTACATGCTCTGCCGGGATGTCATCTCCTCCGAGGTGGGTTCCGACCAC
GAGCTCCAGGCGGTCCTGCTGACCTGCCTGTACCTCTCCTACTCCTACATGGGCAACGAG
ATCTCCTACCCGCTCAAGCCCTTCCTGGTGGAGAGCTGCAAGGAGGCCTTTTGGGACCGC
TGTCTCTCCGTCATCAACCTCATGAGCTCCAAGATGCTGCAGATCAACGCCGACCCCCAC
TACTTCACGCAGGTGTTCTCCGACCTGAAGAACGAGAGCGGCCAGGAGGACAAGAAGCGG
CTCCTCCTCGGGCTGGACCGGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 307 |
| Molecular Weight
| 34088.0 |
| Theoretical pI
| 9.8 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Cyclin-dependent kinase 5 activator 1
MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSA
KKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTG
VSSSVKKAPHPAVSSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRS
VDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNE
ISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKR
LLLGLDR
|
| External Links |
|---|
| GenBank ID Protein
| CAA55534.1 |
| UniProtKB/Swiss-Prot ID
| Q28199 |
| UniProtKB/Swiss-Prot Entry Name
| CD5R1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| X78934 |
| GeneCard ID
| CDK5R1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
