| Identification |
|---|
| BMDB Protein ID
| BMDBP01091 |
| Secondary Accession Numbers
| None |
| Name
| PRKCA-binding protein |
| Synonyms
|
Not Available
|
| Gene Name
| PICK1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| PICK1 |
| Gene Sequence
|
>1254 bp
ATGTTTGCAGACTTGGGTTATGACATCGAGGAGGATAAACTCGGAATCCCTACTGTGCCT
GGGAAGGTGACCCTGCAGAAGGATGCTCAGAACCTGATCGGGATCAGCATTGGAGGAGGG
GCCCAGTACTGTCCCTGCCTGTATATTGTTCAGGTGTTTGACAACACGCCCGCCGCGCTG
GACGGCACCGTAGCAGCTGGCGATGAGATCACGGGGGTCAATGGCAGGTCAATCAAAGGA
AAAACTAAGGTGGAGGTGGCCAAGATGATTCAGGAGGTGAAGGGGGAGGTGACCATCCAC
TATAACAAGCTGCAGGCGGACCCCAAGCAGGGCATGTCCCTGGACATTGTGTTGAAGAAG
GTGAAGCATCGGCTGGTCGAGAACATGAGCTCGGGGACGGCAGATGCTCTGGGCCTGAGC
CGGGCCATCCTGTGCAATGATGGGCTCGTCAAGAGGCTGGAGGAGCTGGAGCGGACTGCT
GAGCTGTATAAAGGGATGACAGAACACACCAAGAACCTCCTCCGGGCCTTTTATGAGCTG
TCACAGACGCACCGTGCCTTTGGGGACGTGTTCTCTGTAATCGGGGTGCGGGAGCCTCAG
CCCGCTGCGAGTGAGGCTTTTGTGAAGTTCGCCGACGCCCACCGCAGCATCGAGAAGTTT
GGCATCCGGCTCCTGAAGACCATCAAGCCGATGCTGACAGACTTGAACACGTACCTCAAC
AAGGCCATCCCGGACACTCGCCTCACCATCAAGAAGTACCTGGACGTGAAGTTCGAGTAC
CTGTCCTACTGCCTGAAGGTCAAGGAGATGGACGACGAGGAGTACAGCTGCATTGCCCTC
GGGGAGCCCCTGTACCGCGTGAGCACAGGCAACTACGAGTACCGCCTGATCCTGCGCTGC
CGCCAGGAGGCGCGCGCCCGCTTCTCCCAGATGCGCAAGGACGTGCTGGAGAAGATGGAG
CTGCTCGACCAGGAGCACGTCCAGGACATCGTGTTACAGCTGCAGCGCTTCGTGTCCACC
ATGTCCAAGTACTACAACGACTGCTACTCGGTGCTGCGTGACGCCGACGTCTTCCCCATC
GAGGTGGATCTGGCGCACACCACGCTGGCCTACGGCCTCAGCCAGGACGAGTTCACGGAT
GGCGAGGACGAGGAGGACGAAGACGAGGAGGACACGGCAGCCGGGGAGCCGCCCAGGGAT
TCGCGAGGGGCTGCCGGGCCCCTGGACAAGGGCGGGAGCTGGTGTAACTCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 417 |
| Molecular Weight
| 46729.0 |
| Theoretical pI
| 4.82 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>PRKCA-binding protein
MFADLGYDIEEDKLGIPTVPGKVTLQKDAQNLIGISIGGGAQYCPCLYIVQVFDNTPAAL
DGTVAAGDEITGVNGRSIKGKTKVEVAKMIQEVKGEVTIHYNKLQADPKQGMSLDIVLKK
VKHRLVENMSSGTADALGLSRAILCNDGLVKRLEELERTAELYKGMTEHTKNLLRAFYEL
SQTHRAFGDVFSVIGVREPQPAASEAFVKFADAHRSIEKFGIRLLKTIKPMLTDLNTYLN
KAIPDTRLTIKKYLDVKFEYLSYCLKVKEMDDEEYSCIALGEPLYRVSTGNYEYRLILRC
RQEARARFSQMRKDVLEKMELLDQEHVQDIVLQLQRFVSTMSKYYNDCYSVLRDADVFPI
EVDLAHTTLAYGLSQDEFTDGEDEEDEDEEDTAAGEPPRDSRGAAGPLDKGGSWCNS
|
| External Links |
|---|
| GenBank ID Protein
| AAI11359.1 |
| UniProtKB/Swiss-Prot ID
| Q2T9M1 |
| UniProtKB/Swiss-Prot Entry Name
| PICK1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC111358 |
| GeneCard ID
| PICK1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
