| Identification |
|---|
| BMDB Protein ID
| BMDBP01133 |
| Secondary Accession Numbers
| None |
| Name
| Presenilins-associated rhomboid-like protein, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| PARL |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in serine-type peptidase activity |
| Specific Function
| Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| Not Available |
| SNPs
| PARL |
| Gene Sequence
|
>1134 bp
ATGGCGTGGGGAGGCTGGGCGCAGAGAGGCTGGGGCTGTGGACAAGCGTGGACTCTGCCA
GTGTGCGGCGGCAGCTATGAAGAGCTCACTGCGGCCCTGGCCCCGTCGCGGCTGCTCCGG
CGCAGGTTTAACTTTTTTATTCAGCAAAAATGTGGATTCAGAAAAGCACCCAGGAAGGTT
GAACCACGAAGATCGGACACAAGCAGTGAAGCGTACAAGAGAAGTGCTTTGATTCCTCCT
GTAGAAGAAACAGCCTTTTACCCTTCTCCCTATCCTATAAGGACTCTTGTAAAGCCTTTG
TTTTTTACTGTTGGGTTTACAGGCTGTGCATTTGGATCAGCTGCTATTTGGCAATATGAA
TCACTGAAATCCAAGGTCCAAAGTTATTTTGATGGTATAAAAGCTGATTGGTTGGATAGC
ATAAGACCGCAGAAGGAAGGAGACTTCAGAAAGGAGATTAACAAGTGGTGGAATAACCTA
AGTGATGGCCAGCGGACTGTGACAGGTATCATAGCTGCAAATGTTTTTGTATTTTGTTTG
TGGAGAGTACCTTCTCTGCAGCGGACAATGATCAGATACTTCACATCCAATCCAGCCTCA
AAGGTCCTTTGTTCTCCAATGTTGCTGTCAACGTTCAGTCATTTCTCCTTGTTTCACATG
GCAGCCAATATGTATGTCTTGTGGAGCTTCTCCTCCAGCATAGTGAACATTCTGGGTCAA
GAGCAGTTCATGGCAGTATACTTATCTGCAGGTGTTATTTCCACTTTTGTCAGTTATGTG
TGTAAAGTTGCCACAGGAAGATATGGACCATCACTTGGTGCATCTGGCGCAATCATGACT
GTCCTTGCTGCCGTCTGCACTAAGATCCCGGAAGGGAGACTCGCCATCATCTTCCTTCCA
ATGTTCACGTTCACAGCAGGGAATGCCCTAAAAGCCATTATTGCCATGGATACAGCAGGA
ATGATCCTGGGATGGAAATTTTTTGATCATGCAGCACATCTTGGGGGAGCTCTCTTTGGA
ATATGGTATATTACTTACGGTCATGAACTCATTTGGAAGAACAGGGAGCCTCTAGTGAAA
ATTTGGCATGAAATGAGGACTAACAGCCCCAAAAAAGGAGGTGGCTCTAAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 377 |
| Molecular Weight
| 42301.0 |
| Theoretical pI
| 10.24 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 100-119
- 166-185
- 206-228
- 243-260
- 271-287
- 294-316
- 331-352
|
| Protein Sequence
|
>Presenilins-associated rhomboid-like protein, mitochondrial
MAWRGWAQRGWGCGQAWTLPVCGGSYEELTAALAPSRLLRRRFNFFIQQKCGFRKAPRKV
EPRRSDTSSEAYKRSALIPPVEETAFYPSPYPIRTLVKPLFFTVGFTGCAFGSAAIWQYE
SLKSKVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVFVFCL
WRVPSLQRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNILGQ
EQFMAVYLSAGVISTFVSYVCKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIFLP
MFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYITYGHELIWKNREPLVK
IWHEMRTNSPKKGGGSK
|
| External Links |
|---|
| GenBank ID Protein
| AAX08693.1 |
| UniProtKB/Swiss-Prot ID
| Q2KHV4 |
| UniProtKB/Swiss-Prot Entry Name
| PARL_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT020676 |
| GeneCard ID
| PARL |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
