<?xml version="1.0" encoding="UTF-8"?>
<protein>
  <version>1.0</version>
  <creation_date>2018-05-07 22:25:35 UTC</creation_date>
  <update_date>2020-05-20 21:08:06 UTC</update_date>
  <accession>BMDBP01135</accession>
  <secondary_accessions>
  </secondary_accessions>
  <protein_type>Enzyme</protein_type>
  <synonyms>
  </synonyms>
  <gene_name>HARS1</gene_name>
  <general_function>Translation, ribosomal structure and biogenesis</general_function>
  <specific_function>Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance.</specific_function>
  <pathways>
    <pathway>
      <name>Histidine Metabolism</name>
      <smpdb_id>SMP0087219</smpdb_id>
      <kegg_map_id/>
    </pathway>
    <pathway>
      <name>Protein Synthesis: Histidine</name>
      <smpdb_id>SMP0119392</smpdb_id>
      <kegg_map_id/>
    </pathway>
  </pathways>
  <metabolite_associations>
    <metabolite>
      <accession>BMDB0000177</accession>
      <name>L-Histidine</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000538</accession>
      <name>Adenosine triphosphate</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000045</accession>
      <name>Adenosine monophosphate</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000250</accession>
      <name>Pyrophosphate</name>
    </metabolite>
  </metabolite_associations>
  <go_classifications>
  </go_classifications>
  <subcellular_locations>
  </subcellular_locations>
  <gene_properties>
    <chromosome_location>7</chromosome_location>
    <locus/>
    <gene_sequence>&gt;1530 bp
ATGGCTGATCGTGCGGCGCTGGAGGATCTGGTGCGAGTTCAGGGAGAGCGTGTGCGGGGC
CTTAAGCAGCAGAAGGCCAGCGCGGAGCAGATCGAGGAGGAGGTGGCAAAACTACTGAAA
CTGAAGGCACAGCTGGGCCCTGATGAAGGAAAACCGAAGTTTGTGCTCAAAACCCCCAAG
GGCACAAGAGATTATAGTCCCCGGCAGATGGCAGTTCGAGAGAAGGTGTTTGATGTAATC
ATCAGCTGCTTCAAGCGCCATGGTGCAGAAGTGATTGATACACCTGTATTTGAACTAAAG
GAAACACTGACTGGAAAGTATGGAGAAGACTCTAAGCTTATCTATGACTTGAAGGACCAG
GGTGGGGAGCTGCTCTCTCTTCGATATGACCTCACTGTTCCTTTTGCTCGATACTTGGCA
ATGAATAAACTGACCAACATTAAACGCTACCACATAGCAAAAGTATATCGGCGGGATAAC
CCAGCCATGACCCGAGGCCGATATCGGGAATTCTACCAATGTGATTTTGACATTGCTGGG
CAGTTTGACCCCATGCTTCCTGATGCAGAGTGCCTGAAGATCATGTGTGAGATCCTGAGT
TCACTCCAGATTGGCGACTTCCTGGTCAAGGTGAATGATCGGCGCATCTTAGATGGGATG
TTTGCCATCTGTGGTGTTCCAGATAGCAAGTTCCGCACCATCTGCTCCTCTGTGGACAAG
CTGGACAAGGTGTCCTGGGAGGAAGTAAAGAATGAGATGGTAGGAGAGAAGGGCCTGGCA
CCTGAGGTGGCTGACCGCATTGGGGACTACGTCCAGCAACACGGTGGAGTATCCCTGGTG
GAACAGCTGCTCCAGGATCCTAAACTGTCCCAGAACAAGCAGGCCCTCGAGGGCCTGGGA
GACCTGAAGCTGCTATTTGAGTATCTGACCTTGTTTGGCATTGCTGACAAGATCTCCTTC
GACCTGAGCCTTGCTCGAGGACTGGACTACTATACCGGCGTGATCTATGAGGCAGTGCTG
CTACAGCCTCCAGCCCGAGCAGGGGAAGAACCCCTGGGTGTGGGCAGCGTGGCTGCTGGA
GGGCGCTATGATGGGCTGGTGGGCATGTTTGATCCCAAAGGGCGCAAGGTGCCCTGTGTA
GGGCTCAGCATTGGAGTAGAGCGGATCTTTTCCATCGTGGAGCAGAGGCTGGAGGCCTTG
GAGGAGAAGGTACGGACCACAGAGACACAGGTGCTTGTGGCATCTGCACAGAAGAAGCTG
CTGGAAGAGAGACTGAAGCTCATCTCAGAGTTATGGGATGCTGGGATCAAGGCAGAACTG
CTCTACAAAAAGAACCCCAAGTTACTGAATCAGCTGCAGTACTGTGAGGAGACAGGCATC
CCACTGGTGGCCATCATTGGTGAGCAAGAGCTCAAGGATGGGGTCATCAAGCTGCGCTCA
GTGGCCAGCAGGGAAGAGGTGGACGTCCGAAGAGAAGACCTTGTGGAGGAAATCAAAAGG
AGAACAAGCCAGCCGCTTTGCATCTGCTGA</gene_sequence>
  </gene_properties>
  <protein_properties>
    <residue_number>509</residue_number>
    <molecular_weight>57285.0</molecular_weight>
    <theoretical_pi>5.75</theoretical_pi>
    <pfams>
    </pfams>
    <transmembrane_regions>
    </transmembrane_regions>
    <signal_regions>
      <region>None</region>
    </signal_regions>
    <polypeptide_sequence>&gt;Histidyl-tRNA synthetase, cytoplasmic
MADRAALEDLVRVQGERVRGLKQQKASAEQIEEEVAKLLKLKAQLGPDEGKPKFVLKTPK
GTRDYSPRQMAVREKVFDVIISCFKRHGAEVIDTPVFELKETLTGKYGEDSKLIYDLKDQ
GGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAG
QFDPMLPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVPDSKFRTICSSVDK
LDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLG
DLKLLFEYLTLFGIADKISFDLSLARGLDYYTGVIYEAVLLQPPARAGEEPLGVGSVAAG
GRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKVRTTETQVLVASAQKKL
LEERLKLISELWDAGIKAELLYKKNPKLLNQLQYCEETGIPLVAIIGEQELKDGVIKLRS
VASREEVDVRREDLVEEIKRRTSQPLCIC</polypeptide_sequence>
  </protein_properties>
  <genbank_protein_id>AAI12732.1</genbank_protein_id>
  <uniprot_id>Q2KI84</uniprot_id>
  <uniprot_name>HARS1_BOVIN</uniprot_name>
  <pdb_ids>
  </pdb_ids>
  <genbank_gene_id>BC112731</genbank_gene_id>
  <genecard_id>HARS1</genecard_id>
  <geneatlas_id/>
  <general_references>
  </general_references>
  <metabolite_references>
  </metabolite_references>
</protein>
