| Identification |
|---|
| BMDB Protein ID
| BMDBP01143 |
| Secondary Accession Numbers
| None |
| Name
| Mitogen-activated protein kinase 7 |
| Synonyms
|
Not Available
|
| Gene Name
| MAPK7 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression (By similarity). Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction (By similarity). |
| Pathways
|
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| MAPK7 |
| Gene Sequence
|
>2346 bp
ATGGCTGAGCCCCTGAAGGAGGACGACGGTGAGGACGGCTCCGGGGAGCCCCCCGGGCCG
GTGAAGGCGGAACCCGCTGGCACCGCCGCCTCGGTGGCTGCCAAGAACTTGGCCCTGCTG
AAGGCGCGGTCCTTCGACGTGACCTTCGACGTGGGGGACGAGTACGAGATCATCGAGACC
ATTGGCAACGGGGCCTACGGGGTGGTGTCCTCCGCGCGCCGCCGCCTCACCGGCCAGCAG
GTGGCCATTAAGAAGATCCCTAATGCTTTTGACGTGGTGACCAATGCCAAGCGGACCCTC
AGAGAGCTGAAGATCCTCAAGCACTTCAAGCACGACAACATCATTGCCATAAAGGACATC
CTGAGGCCCACTGTACCCTATGGCGAGTTCAAATCTGTCTACGTGGTCCTGGACCTGATG
GAGAGCGACCTGCACCAGATCATCCACTCCTCACAGCCGCTGACACTGGAGCATGTGCGC
TACTTCCTGTACCAGCTGCTGCGGGGCCTCAAGTACATGCACTCGGCTCAGGTCATCCAC
CGCGACCTCAAGCCCTCCAACCTACTGGTGAACGAGAACTGCGAGCTCAAGATTGGGGAC
TTTGGCATGGCCCGTGGCCTGTGCACCTCGCCCGCTGAGCACCAGTACTTCATGACCGAG
TATGTGGCCACTCGCTGGTACCGCGCCCCTGAGCTCATGCTCTCGCTGCACGAGTACACG
CAGGCCATCGACCTGTGGTCCGTGGGCTGCATCTTTGGGGAGATGCTGGCCCGGCGCCAA
CTCTTCCCAGGCAAAAACTATGTGCACCAGCTGCAGCTGATCATGACGGTGCTAGGTACC
CCGTCGCCGGCCGTGATTCAGGCTGTGGGAGCTGAGAGGGTGCGGGCCTATATCCAGAGC
CTGCCACCACGCCAGCCTGTGCCCTGGGAGACGGTGTACCCGGGCGCCGACCGCCAGGCG
CTCTCCCTACTGGGGCGCATGCTACGTTTTGAGCCCAGCGCCCGTGTCTCTGCAGCTGCT
GCCCTCCGCCACCCCTTCCTGGCCAAGTACCATGACCCCGACGACGAGCCTGACTGTGCC
CCGCCCTTTGACTTTGCCTTTGACCGTGAAGCCCTCACACGGGAGCGCATTAAGGAGGCC
ATTGTGGCGGAGATCGAGGACTTCCATGCACGGCGCGAGGGCATCCGCCAGCAGATCCGC
TTCCAGCCTTCCTTGCAGCCTGTGGCCAGTGAGCCTGGCTGCCCCGATGTGGAAATGCCC
AGCCCCTGGGCTCCGAGTGGGGACTGCGCCATGGAGTCCCCTCCGCCAGCCCCACTGCCA
TGCCCTGGCCCTGCGCCCGACACCATCGATCTGACCCTGCAGCCGCCCCCACCAGCCAGT
GAACCAGCCCCTCCAAAGAAGGAGGGGGCCATCTCAGACAACACCAAGGCTGCCCTCAAG
GCTGCCTTGCTCAAGTCCTTGCGGAGCCGGCTCCGAGATGGCCCCAGTGCCCCCCTGGAA
GCTCCTGAGCCTCGGAAGCCGGTGACTGCTCAGGAGCGCCAGCGGGAGCGGGAGGAGAAA
CGCCGACGGCGGCAGGAGCGGGCCAAGGAGCGAGAGAAGAGGCGGCAGGAGCGGGAGCGC
AAGGAGCGGGGCGCGGGGGTCTCGGGGGGCCCCTCCGCTGACCCCCTGGCTGGGCTGGTG
CTTAGCGACAACGACCGCAGCCTGCTGGAGCGTTGGACTCGCATGGCCCAGCCCCCCGCC
CCCGCACCCGCCACAGCCCGGCCCCCCAGCCCTCCCGCTGGCCCTGCCACCCAGCCCACT
GGGCCCCTGCCACAGCCGGCCTGCCCACCCCCTGCACCTGCAGCTGGCCCTGCTGCTCCC
CAGACCACCGCCGCCTCCGGCCTCCTGGCCCCCCAGCCGCTGGTGCCGCCCCCTGGGCTG
CCCGGCCCCAGTGCCCTGAGTGTTCTCCCTTACTTCCCCTCTGGCCCACCCCCTCCAGAC
CCCGGGGGGGCCCCACAGCCCTCCACATCGGAGTCACCTGACGTCACCCTGGTGACCCAG
CAGCTGTCCAAGTCACAGGTGGAGGACCCTTTGCCCCCCGTGTTCTCGGGCACCCCCAAG
GGCAGTGGAGCTGGGTATGGTGTTGGCTTTGACCTGGAGGAATTCCTAAACCAGTCTTTT
GACATGGGTGTGGCTGATGGGCCACAAGACGGCCAGGCAGACTCAGCCTCGCTCTCAGCC
TCCCTGCTCGCTGACTGGCTCGAGGGCCACGGCATGAACCCTGCTGACATCGAGTCCCTG
CAGCGTGAGATCCAGATGGATTCCCCCATGCTGCTGGCCGACCTGCCCGACCTCCAAGAG
CCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 781 |
| Molecular Weight
| 84832.0 |
| Theoretical pI
| 5.49 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Mitogen-activated protein kinase 7
MAEPLKEDDGEDGSGEPPGPVKAEPAGTAASVAAKNLALLKARSFDVTFDVGDEYEIIET
IGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDI
LRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIH
RDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYT
QAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMTVLGTPSPAVIQAVGAERVRAYIQS
LPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARVSAAAALRHPFLAKYHDPDDEPDCA
PPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMP
SPWAPSGDCAMESPPPAPLPCPGPAPDTIDLTLQPPPPASEPAPPKKEGAISDNTKAALK
AALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERER
KERGAGVSGGPSADPLAGLVLSDNDRSLLERWTRMAQPPAPAPATARPPSPPAGPATQPT
GPLPQPACPPPAPAAGPAAPQTTAASGLLAPQPLVPPPGLPGPSALSVLPYFPSGPPPPD
PGGAPQPSTSESPDVTLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSF
DMGVADGPQDGQADSASLSASLLADWLEGHGMNPADIESLQREIQMDSPMLLADLPDLQE
P
|
| External Links |
|---|
| GenBank ID Protein
| AAI42511.1 |
| UniProtKB/Swiss-Prot ID
| A5PKJ4 |
| UniProtKB/Swiss-Prot Entry Name
| MK07_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC142510 |
| GeneCard ID
| MAPK7 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
