1.0 2018-05-07 22:25:38 UTC 2020-05-20 21:09:23 UTC BMDBP01144 Enzyme CLK3 Involved in ATP binding Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells (By similarity). BMDB0001341 ADP 21 >1473 bp ATGCATCACTGTAAGCGATACCGCTCCCCTGAGCCAGACCCGTACCTGAGCTACCGATGG AAGAGGAGGAGGTCTTACAGTCGGGAGCACGAAGGGAGATTGCGATACCCGTCTCGAAGG GAGCCGCCGCCACGGAGATCTCGGTCTAGAAGCCATGACCGCTTGCCCTACCAGAGGAGA TACCGGGAGCACCGTGACAGCGACACATACCGGTGTGAAGACCGGAGCCCATCCTTTGGG GAGGACTACTACGGATCTTCACGTTGCCATCATCGTCGGCGATCACGGGAGAGGGAGCCA TACCGGACCCGCAAGCACGCCCACCACTGCCACAAACGCCGCACCAGGTCTTGTAGCAGC GCCTCCTCGAGAAGCCAACAGAGCAGTAAGCGCAGCAGCCGGAGTGTGGAAGATGACAAG GAGGGCCACCTGGTGTGCCGGATCGGCGATTGGCTCCAAGAGCGATATGAGATCGTGGGG AACCTGGGTGAAGGCACCTTTGGCAAGGTGGTGGAGTGCTTGGACCATGCCAGAGGGAAG TCTCAGGTTGCCCTGAAGATCATCCGCAATGTAGGCAAGTACCGGGAGGCCGCCCGGCTA GAAATCAACGTTCTCAAGAAGATCAAGGAGAAGGACAAAGAGAACAAGTTCCTGTGCGTC TTGATGTCTGACTGGTTCAACTTCCACGGTCACATGTGCATCGCCTTTGAGCTCCTGGGC AAGAACACCTTTGAGTTCCTAAAGGAGAATAACTTCCAGCCTTACCCTCTACCACATGTC CGGCACATGGCCTACCAGCTCTGCCACGCCCTTAGATTTCTACATGAGAACCAACTGACC CACACAGACTTGAAGCCAGAGAACATCCTGTTTGTGAATTCTGAGTTTGAAACCCTCTAC AATGAGCACAAGAGCTGTGAGGAGAAGTCAGTGAAGAACACCAGCATCCGAGTGGCTGAC TTCGGCAGTGCTACCTTTGACCATGAGCATCACACGACCATCGTGGCCACCCGTCACTAT CGTCCACCTGAGGTGATCCTTGAGCTGGGCTGGGCACAGCCGTGCGATGTCTGGAGCATC GGCTGCATTCTCTTTGAGTACTACCGGGGCTTCACACTCTTCCAGACCCACGAGAACCGA GAGCATTTGGTGATGATGGAGAAGATCCTAGGGCCCATCCCATCACACATGATCCACCGC ACAAGGAAGCAGAAATATTTCTACAAAGGGGGCCTGGTTTGGGATGAGAACAGTTCTGAC GGCCGGTATGTGAAGGAGAACTGCAAACCTCTGAAGAGTTATATGCTCCAAGACACTCTG GAGCACGTGCAGCTGTTTGACCTGATGAGGAGGATGTTAGAATTTGACCCTGCCCAGCGC ATCACACTGGCGGAGGCCCTGCTGCACCCCTTCTTTGCTGGTCTGACCCCTGAGGAGCGG TCCTTCCACACCAGCCGCAACCCAAGCAGATGA 490 58628.0 9.71 None >Dual specificity protein kinase CLK3 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRR YREHRDSDTYRCEDRSPSFGEDYYGSSRCHHRRRSREREPYRTRKHAHHCHKRRTRSCSS ASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGK SQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLG KNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLY NEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSI GCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSD GRYVKENCKPLKSYMLQDTLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEER SFHTSRNPSR AAI04551.1 Q3SX21 CLK3_BOVIN BC104550 CLK3