| Identification |
|---|
| BMDB Protein ID
| BMDBP01145 |
| Secondary Accession Numbers
| None |
| Name
| MAP kinase-activated protein kinase 3 |
| Synonyms
|
Not Available
|
| Gene Name
| MAPKAPK3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 22 |
| Locus
| Not Available |
| SNPs
| MAPKAPK3 |
| Gene Sequence
|
>1155 bp
ATGGACGTGGAGACAGCAGAGGAGCAGGGGGGCCCTGCGCCCCCGTCAGGTGTACCCTGC
GGACCTTGTTCCGCCGGCGCTCCCGCCCTCGGGGGGCGGCGGGAGCCCAAGAAGTACGCA
GTGACCGATGACTACCAGTTGTCCAAGCAGGTGCTGGGCTTGGGTGTGAACGGCAAGGTG
CTGGAGTGCTTCCACCGGCGCACTGGGCAGAAGTGTGCCCTGAAGCTCCTGTACGACAGC
CCCAAGGCCCGGCAGGAGGTGGACCACCACTGGCAGGCCTCCGGTGGCCCCCACATCGTG
CGCATCCTGGATGTTTATGAGAATATGCATCACAGCAAACGCTGTCTCCTCATCATCATG
GAATGCATGGAAGGTGGTGAGTTGTTCAGCAGGATTCAGGAGCGTGGTGACCAGGCTTTC
ACTGAAAGAGAAGCCGCAGAGATCATGCGGGATATTGGCACTGCCATCCAGTTTCTGCAC
AGCCGGAACATCGCCCACCGAGATGTCAAGCCTGAAAACCTGCTCTACACGTCCAAGGAT
AAAGATGCGGTGCTGAAGCTCACGGACTTTGGCTTTGCCAAAGAGACCACCCAGAATGCC
CTGCAAACTCCATGTTACACTCCCTACTATGTGGCTCCTGAGGTTCTGGGTCCAGAGAAG
TATGACAAGTCATGTGACATGTGGTCCCTGGGCGTCATCATGTACATCCTCCTGTGCGGC
TTCCCGCCCTTCTACTCCAACACGGGCCAGGCCATCTCCCCGGGGATGAAGAGGAGGATC
CGCCTGGGCCAGTATGGCTTCCCCAGCCCTGAGTGGTCCGAGGTCTCCGAGGATGCCAAG
CAGCTGATCCGCCTCCTGCTGAAGACGGACCCCACCGAGAGGCTGACCATCACGCAATTC
ATGAACCATCCCTGGATCAACCAATCGATGGTGGTGCCCCAGACTCCACTCCACACGGCC
CGAGTGCTGCAGGAGGACAGAGACCACTGGGATGAAGTCAAGGAGGAGATGACCAGCGCC
TTGGCAACCATGCGGGTGGACTATGACCAGGTGAAGATCAAGGACCTGAAGACCTCTAAC
AACCGGCTCCTCAACAAGCGGAGGAAGAAGCAGGCAGGCAGCTCCTCCGGCTCGCAGGGC
TGCAACAATCAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 384 |
| Molecular Weight
| 43316.0 |
| Theoretical pI
| 7.72 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>MAP kinase-activated protein kinase 3
MDVETAEEQGGPAPPSGVPCGPCSAGAPALGGRREPKKYAVTDDYQLSKQVLGLGVNGKV
LECFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVRILDVYENMHHSKRCLLIIM
ECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSRNIAHRDVKPENLLYTSKD
KDAVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCG
FPPFYSNTGQAISPGMKRRIRLGQYGFPSPEWSEVSEDAKQLIRLLLKTDPTERLTITQF
MNHPWINQSMVVPQTPLHTARVLQEDRDHWDEVKEEMTSALATMRVDYDQVKIKDLKTSN
NRLLNKRRKKQAGSSSGSQGCNNQ
|
| External Links |
|---|
| GenBank ID Protein
| ABG67036.1 |
| UniProtKB/Swiss-Prot ID
| Q3SYZ2 |
| UniProtKB/Swiss-Prot Entry Name
| MAPK3_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT026197 |
| GeneCard ID
| MAPKAPK3 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
