| Identification |
|---|
| BMDB Protein ID
| BMDBP01162 |
| Secondary Accession Numbers
| None |
| Name
| Hepatocyte growth factor receptor |
| Synonyms
|
Not Available
|
| Gene Name
| MET |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| Not Available |
| SNPs
| MET |
| Gene Sequence
|
>4155 bp
ATGAAGGCCCCTGCTGTGCTTGCACCTGGCATTCTTGTGCTTCTGTTTACCTTCGTGCAG
AAGAGCAATGGGGAGTGTAAAGAGGCACTAGTAAAATCCAGGATGAATGTGAACATGCAA
TATCAGCTTCCTAACTTCACTGCAGAAACATCCATTCAGAATGTTGTTTTGCACAAACAT
CACATTTACCTCGGTGCCATTAACTACATTTACGTTTTAAATGACAAAGACCTTCAGAAG
GTTGCTGAGTACAAGACTGGGCCTGTGCTGGAACACCCAGATTGTTTCCCATGTCAGGAC
TGCAGCCATAAAGCCAATTTATCAGGTGGTGTTTGGAAAGATAACATCAACATGGCTCTG
CTTGTTGACACGTACTATGATGATCAACTCATTAGCTGTGGCAGTGTCCACAGAGGGACC
TGCCAGCGACACGTCCTTCCACCCAACAATACTGCAGACATAGAGTCGGAGGTTCACTGC
ATGTACTCTCCTCAGGCAGACGAAGAGACCAACCAGTGTCCTGACTGTGTGGTGAGTGCC
CTGGGAACCAAAGTCCTACTGTCTGAAAAGGATCGATTCATCAACTTCTTCGTGGGCAAT
ACCATAAATTCTTCTTACCTTCCAGATTATATATTGCACTCGATATCAGTGAGAAGGCTA
AAGGAAACACAAGATGGTTTTAAGTTTTTGACAGACCAATCCTATATTGATGTTCTACCT
GAACTCCGAGATTCCTACCCCATTAAGTATGTCCACGCCTTTGAAAGCAACCATTTTATT
TACTTTTTGACGGTCCAGCGGGAAACTCTAGATGCTCAGACTTTTCACACAAGAATAATC
AGGTTCTGTTCCGCAGACTCTGGATTGCATTCGTACATGGAAATGCCTCTGGAGTGTATT
CTGACGGAAAAGAGAAGAAAGAGATCCACAAAGCAGGAAGTGTTTAATATTCTCCAAGCT
GCATATGTCAGTAAGCCTGGGGCTCAGCTCGCTAGGCAAATAGGTGCCAGCCTGAATGAT
GACATTCTGTACGGGGTGTTTGCACAAAGCAAGCCAGATTCCTCAGAACCAATGAATCGT
TCTGCTGTCTGTGCATTCCCTGTCAAATATGTCAATGAGTTCTTCAACAAAATCGTCAAC
AAAAACAATGTGAGATGTCTCCAGCACTTTTATGGCCCCAACCATGAACACTGCTTCAAT
AGGACACTTTTGAGAAATTCATCAGGATGTGAAGTGCGCAATGATGAATATCGAACGGAG
TTTACCACAGCTTTGCCACGCGTTGACTTATTCACGGGCCAGTTCAACCAAGTCCTCTTA
ACATCTATATCCACCTTTATCAAAGGAGATCTCACCATCGCTAATCTCGGGACATCAGAA
GGTCGATTCATGCAGGTTGTGGTTTCTCGATCAGGATCATTAACTCCTCATGTGAATTTT
CACCTGGATTCCCACCCTGTGTCTCCAGAAGTGATTGTGGAGCACCCGCTAAACCAGAAT
GGCTATACACTGGTTGTCACTGGGAAGAAGATCACCAAGATCCCGCTGAATGGCCTGGGC
TGTGAACATTTCCAGTCCTGCAGTCAGTGCCTCTCAGCCCCTTCCTTTGTGCAATGTGGC
TGGTGCCATGATAAATGTGTGCGATTGGAGGAATGCTCCAGTGGAACGTGGACTCAAGAG
ACCTGTCTGCCAACAATCTACAAGGTTTTTCCAACTAGTGCCCCCCTTGAAGGAGGGACA
ACACTGACTGTTTGTGGCTGGGACTTTGGATTCAAGAGGAATAATAAATTTGATTTGAAG
AAAACCAGAGTTCTCCTTGGCAATGAGAGCTGCACCTTAACCTTAACTGAGAGCACAACA
AACATGTTGAAATGCACAGTTGGTCCTGCAATGAATGAACATTTCAATATGTCCATAGTT
ATTTCAAACAGCCGTGGGTCAGTAGAGTATAGTGCGTTTTCCTATGTGGATCCTATAATA
ACAAGTATTTCTCCAAATTATGGTCCAAAAACTGGTGGCACTTTACTTACATTAACTGGA
AAGCACCTAAACAGTGGAAATTCAAGACACATTTCAATTGGTGGAAAAACATGTACTTTA
AAAAGTGTTTCACATAGTATTCTCGAATGTTATACCCCAGCCCAAAGTGCTCCAACTGAG
TTTTCTGTTAAGTTGAAAATTGACTTAGCCAACCGAGAGGTGAACAGCTTCATTTACCGG
GAAGACCCCATTGTCTATGAAATACATCCCACCAAATCTTTTATTAGTGGTGGGAGTACA
ATAACAGGTGTTGGAAAAAACCTGAATTCAGTTAGTGTCCTAAGGATGGTAATAAATGTG
CATGAAGCCGGAAGGAACTTTACAGTGGCATGTCAACATCGCTCTAATTCAGAGATAATC
TGCTGTACAACTCCTTCAATAGAACAGCTGAACCTACAACTCCCCCTGAAAACCAAAGCC
TTTTTCATGTTAGATGGGATCCATTCCAAATACTTTGATCTCATTTATGTACATAATCCT
GTGTTTAAGCCTTTTGAAAAGCCAGTGATGATCTCAGTAGGCAATGAAAATGTACTGGAA
ATTAAGGGAAATGATATTGACCCTGAAGCAGTTAAAGGGGAGGTGTTAAAAGTTGGAAAT
AAGAGCTGTGAAAATATACACTCACACTCTGAAGCTGTTTTATGTACGGTCCCCAGTGAC
CTGCTGAAATTGAACAGCGAACTAAATATAGAGTGGAAGCAAGCAATTTCTTCAACTGTT
CTTGGAAAAGTGATAGTTCAACCAGATCAGAATTTCACAGGATTGATTGTTGGTGTTGTC
TCAATATCAATAATACTCTTACTGTTACTCGGGCTTTTCCTGTGGCTGAAAAAAAGGAAG
CAAATTAAAGATCTGGGCAGTGAATTAGTTCGCTATGATGCAAGAGTACACACTCCACAT
TTGGATAGGCTTGTCAGTGCCCGAAGTGTAAGCCCAACTACAGAAATGGTTTCCAATGAA
TCTGTAGACTACCGAGCTACTTTTCCAGAAGACCAGTTTCCTAATGCATCTCAGAATGGG
TCATGCAGACAAGTGCAGTATCCTCTGACAGATCTATCCCCCATCTTAACTAGTGGGGAC
TCTGATATATCCAGTCCATTACTGCAAAATACCATCCACATCGACCTCAGTGCTCTAAAT
CCAGAGCTGGTCCAGGCAGTTCAGCACGTAGTAATTGGGCCGAGCAGTCTGATTGTACAT
TTCAATGAAGTCATAGGAAGAGGACATTTTGGGTGTGTATATCATGGAACTTTGTTGGAC
AACGATGATAAGAAAATTCACTGTGCTGTGAAATCCTTGAATAGAATCACTGACATAGGA
GAAGTTTCCCAATTTCTGACTGAGGGAATCATCATGAAAGATTTTAGTCATCCCAATGTT
CTCTCACTTTTGGGAATCTGCCTTCGAAGTGAGGGGTCTCCACTGGTGGTCCTACCATAC
ATGAAACACGGGGATCTTCGAAATTTCATTAGAAATGAGACTCATAACCCAACTGTAAAA
GATCTTATTGGCTTTGGTCTTCAAGTAGCCAAAGGCATGGAATATCTTGCAAGCAAAAAG
TTTGTCCACAGAGACTTGGCTGCAAGAAACTGTATGCTGGATGAAAAATTCACCGTCAAG
GTTGCTGATTTTGGTCTTGCCAGAGACGTGTATGATAAGGAATACTATAGCGTACACAAC
AAAACAGGTGCAAAACTGCCAGTGAAATGGATGGCTTTAGAAAGCCTGCAGACTCAGAAA
TTTACCACCAAGTCAGATGTGTGGTCCTTTGGCGTGCTTCTCTGGGAACTGATGACAAGA
GGAGCACCACCTTATCCTGACGTCAACACCTTTGACATAACAGTTTACTTGTTGCAAGGA
AGAAGGCTCCTACAACCTGAATACTGCCCAGATCCCTTGTATGAAGTGATGCTGAAATGC
TGGCACCCTAAAGCTGAACTGCGCCCATCCTTTTCTGAACTGGTCTCCAGGATATCCGTG
ATATTCTCTACTTTCATTGGGGAGCACTATGTCCATGTGAATGCTACTTACGTGAACGTC
AAATGTGTCGCTCCATATCCTTCTCTGTTGTCATCACAAGATAATGTCAGTGGCGAGGAT
GATGATGACACATGA
|
| Protein Properties |
|---|
| Number of Residues
| 1384 |
| Molecular Weight
| 154814.0 |
| Theoretical pI
| 6.98 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Hepatocyte growth factor receptor
MKAPAVLAPGILVLLFTFVQKSNGECKEALVKSRMNVNMQYQLPNFTAETSIQNVVLHKH
HIYLGAINYIYVLNDKDLQKVAEYKTGPVLEHPDCFPCQDCSHKANLSGGVWKDNINMAL
LVDTYYDDQLISCGSVHRGTCQRHVLPPNNTADIESEVHCMYSPQADEETNQCPDCVVSA
LGTKVLLSEKDRFINFFVGNTINSSYLPDYILHSISVRRLKETQDGFKFLTDQSYIDVLP
ELRDSYPIKYVHAFESNHFIYFLTVQRETLDAQTFHTRIIRFCSADSGLHSYMEMPLECI
LTEKRRKRSTKQEVFNILQAAYVSKPGAQLARQIGASLNDDILYGVFAQSKPDSSEPMNR
SAVCAFPVKYVNEFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEVRNDEYRTE
FTTALPRVDLFTGQFNQVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGSLTPHVNF
HLDSHPVSPEVIVEHPLNQNGYTLVVTGKKITKIPLNGLGCEHFQSCSQCLSAPSFVQCG
WCHDKCVRLEECSSGTWTQETCLPTIYKVFPTSAPLEGGTTLTVCGWDFGFKRNNKFDLK
KTRVLLGNESCTLTLTESTTNMLKCTVGPAMNEHFNMSIVISNSRGSVEYSAFSYVDPII
TSISPNYGPKTGGTLLTLTGKHLNSGNSRHISIGGKTCTLKSVSHSILECYTPAQSAPTE
FSVKLKIDLANREVNSFIYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVLRMVINV
HEAGRNFTVACQHRSNSEIICCTTPSIEQLNLQLPLKTKAFFMLDGIHSKYFDLIYVHNP
VFKPFEKPVMISVGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHSHSEAVLCTVPSD
LLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIVGVVSISIILLLLLGLFLWLKKRK
QIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNASQNG
SCRQVQYPLTDLSPILTSGDSDISSPLLQNTIHIDLSALNPELVQAVQHVVIGPSSLIVH
FNEVIGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNV
LSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMEYLASKK
FVHRDLAARNCMLDEKFTVKVADFGLARDVYDKEYYSVHNKTGAKLPVKWMALESLQTQK
FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKC
WHPKAELRPSFSELVSRISVIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSQDNVSGED
DDDT
|
| External Links |
|---|
| GenBank ID Protein
| BAD05055.1 |
| UniProtKB/Swiss-Prot ID
| Q769I5 |
| UniProtKB/Swiss-Prot Entry Name
| MET_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB112434 |
| GeneCard ID
| MET |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
