Identification
BMDB Protein ID BMDBP01167
Secondary Accession Numbers None
Name LIM domain kinase 2
Synonyms Not Available
Gene Name LIMK2
Protein Type Enzyme
Biological Properties
General Function Involved in ATP binding
Specific Function Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis by mediating phosphorylation of TPPP. Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro.
Pathways
  • Rac 1 cell motility signaling pathway
  • Rac 1 Cell Motility Signaling Pathway
Reactions Not Available
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 17
Locus Not Available
SNPs LIMK2
Gene Sequence
>1917 bp
ATGGCGGCGCAGGCAGGTGACGATGCCTGGAGGTGTCAGGGCTGTGGAGACTATGTCGCT
CCAAACCAGAGGTTGTACAGGACCGTCAGCGAAGCCTGGCCCACCTCCTGCTTCCGGTGT
TCTGAATGCCAGGATTCCCTCACCAACTGGTACTATGAGAAGGATGGGAAGCTGTACTGC
CACAAGGACTACTGGGGGAAGTTTGGGGAGTTCTGCCATGGATGCTCTCTGTTGATGACG
GGGCCGGTCATGGTGGCCGGGGAGTTCAAGTACCACCCAGAGTGCTTCGCCTGTATGAGC
TGCAAGGTGATCATCGAGGATGGGGACGCATACGCCCTGGTGCAGCACGCCACCCTCTAC
TGTGGGAAGTGCCACAACGAGGTGGTACTGGCACCCATGTTTGAGAGGCTGTCCACGGAA
TCCGTCCAGGACCAGCTGCCCTACTCCGTCACACACATCTCCATGCCAGCCACCACCGAA
GGCAGGCGGGGCTTCTCCGTGTCCGTGGAGAGTGCCTGCTCAAACTACGCCACCACCGTG
CAAGTGAGAGAGGTCAACCGGATGCACATCAGTCCTAACAACCGAAACGCCATCCACCCT
GGGGACCGCATCCTGGAGATCAATGGGGCCCCCGTGCGCACGCTCCGAGTGGAGGAGGTG
GAGGACGCCATTAGCCAGACGACCCAGACACTGCAGCTCCTGATTGAACATGACCCCGTC
TCCCAGCGCCTGGACCAGCTGCAGCTGGATGCACGCCTCTCTCCCTGCGCGCAGAATGAC
AGACACGCGCACACCCTCAGCCCCCTGGACACCAAGGAGAACCTGGAGGGGACACTGAGG
AGACGCTCCCTGAGACGCAGTAACAGCATCTCCAAGTCCCCCGGCCCCAGCTCCCCCAAG
GAGCCGCTCCTGCTCAGCCGTGACATCAGCCGCTCAGAGTCCCTGCGCTGCTCCAGTAGC
TGCTCACAGCAGATCTTCCGGCCCTGTGACCTGATCCACGGCGAGGTCCTGGGGAAGGGC
TTCTTCGGGCAGGCCATCAAGGTGACACACAAAGCCACGGGCAAAGTGATGGTCATGAAT
GAGCTGATCCGGTGTGATGAGGAGACACAGAAGACTTTTCTAACTGAGGTGAAGGTGATG
CGCAGCCTGGACCACCCCAACGTGCTCAAGTTCATCGGCGTACTGTACAAGGACAAGAAG
CTGAACCTGCTGACGGAGTACATCGAGGGGGGCACGCTGAAGGACTTCCTGCGCAACGTG
GACCCGTTCCCCTGGCAGCAGAAGGTCAGGTTTGCCAAAGGCATCGCCTCTGGAATGGCC
TATTTGCATTCCATGTGTATCATCCACCGGGATCTGAACTCGCACAACTGCCTCATCAAG
CTGGACAAGACTGTGGTGGTGGCTGACTTCGGGCTGTCACGGCTCATAGTCGAGGAGAGA
AAGAAGCCCCCCGTGGAAAAGGCCACCACCAAGAAGCGCACCTTGCGCAAGAGCGACCGC
AAGAAGCGCTACACGGTGGTGGGGAACCCCTACTGGATGGCCCCGGAGATGCTGAACGGA
AAGAGCTACGACGAGACGGTGGATGTCTTCTCTTTTGGGATTGTCCTCTGTGAGATAATC
GGGCAGGTGTATGCAGATCCTGACTGCCTGCCCCGAACACTGGACTTCGGCCTCAACGTG
AAGCTCTTCTGGGAGAAGTTTGTCCCCGAAGAGTGCCCCCCAGCCTTCTTCCCCCTGGCA
GCCATCTGCTGCAGACTGGAGCCTGAGAGCAGACCGGCATTCTCCAAACTGGAGGACTTC
TTTGAGGCACTGTCCCTGTACCTGGGGGAGCTGGGCATCCCACTGCCCACAGAGCTGGAG
GACCTGGACCACACCGTGAGCATGGAGTACGGCCTGATCCGGAACCCGCCTCCCTAG
Protein Properties
Number of Residues 638
Molecular Weight 72165.0
Theoretical pI 6.96
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions Not Available
Protein Sequence
>LIM domain kinase 2
MAAQAGDDAWRCQGCGDYVAPNQRLYRTVSEAWPTSCFRCSECQDSLTNWYYEKDGKLYC
HKDYWGKFGEFCHGCSLLMTGPVMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLY
CGKCHNEVVLAPMFERLSTESVQDQLPYSVTHISMPATTEGRRGFSVSVESACSNYATTV
QVREVNRMHISPNNRNAIHPGDRILEINGAPVRTLRVEEVEDAISQTTQTLQLLIEHDPV
SQRLDQLQLDARLSPCAQNDRHAHTLSPLDTKENLEGTLRRRSLRRSNSISKSPGPSSPK
EPLLLSRDISRSESLRCSSSCSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMN
ELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRNV
DPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEER
KKPPVEKATTKKRTLRKSDRKKRYTVVGNPYWMAPEMLNGKSYDETVDVFSFGIVLCEII
GQVYADPDCLPRTLDFGLNVKLFWEKFVPEECPPAFFPLAAICCRLEPESRPAFSKLEDF
FEALSLYLGELGIPLPTELEDLDHTVSMEYGLIRNPPP
GenBank ID Protein AAI09803.1
UniProtKB/Swiss-Prot ID Q32L23
UniProtKB/Swiss-Prot Entry Name LIMK2_BOVIN
PDB IDs Not Available
GenBank Gene ID BC109802
GeneCard ID LIMK2
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available