| Identification |
|---|
| BMDB Protein ID
| BMDBP01170 |
| Secondary Accession Numbers
| None |
| Name
| Protein kinase C eta type |
| Synonyms
|
Not Available
|
| Gene Name
| PRKCH |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| Not Available |
| SNPs
| PRKCH |
| Gene Sequence
|
>2049 bp
ATGTCGTCCGGCACCATGAAGTTCAATGGCTACTTGAGGGTCCGCATTGGCGAGGCCGTG
GGGCTGCAGCCCACCCGCTGGTCCCTGCGCCACTCGCTCTTCAAGAAGGGCTATCAGCTA
CTGGACCCCTACCTGACGGTGAGCGTGGACCAGGTCGTGGGCCAGACTAGGACCAAACAG
AAGACCAACAAGCCCACGTACAATGAGGAGTTCTGCGCCAACGTCACCGACGGTGGCCAC
CTGGAGCTGGCCGTCTTCCACGAGACGCCCCTGGGCTACGACCACTTTGTGGCCAACTGC
ACCCTGCAATTCCAGGAGCTACTGCGCACGGCCGGCGCCTCGGACACCTTCGAGGGCTGG
GTGGATCTGGAGCCAGAAGGGAAAGTGTTTGTCGTAATAACCCTAACAGGGAGTTTCACT
GAAGCTACTCTCCAGAGAGACCGAATCTTCAAACATTTTACCAGGAAGCGCCAAAGGGCT
ATGCGAAGGCGAGTCCACCAGATCAACGGACACAAGTTCATGGCCACATACCTGAGGCAG
CCCACCTACTGCTCTCACTGCAGGGAGTTTATCTGGGGTGTATTTGGAAAACAGGGTTAT
CAATGCCAAGTGTGCACCTGTGTTGTCCACAAACGCTGCCATCATCTAATTGTTACAGCC
TGCACTTGCCAAAACAATATTAACAAAGTGGATTCAAAGACTGCTGAGCAGAGGTTTGGA
ATCAACATCCCACACAAGTTCAGCGTCCACAACTATAAGGTGCCGACGTTCTGCGACCAC
TGTGGCTCCCTGCTCTGGGGCATAATGCGACAAGGACTTCAGTGTAAAATATGTAAAATG
AATGTACACATTCGATGTCAGGCGAACGTGGCCCCAAACTGCGGGGTAAACGCGGTGGAG
CTGGCCAAGACTCTGGCAGGAATGGGCCTCCAACCCGGAAATATTTCTCCAACCTCGAAG
CTTGTTTCTAGATCAACCCTAAGACGACAAGGAAAGGAGAGCACCAAAGAAGGAAATGGC
ATTGGGGTAAATTCCTCCAACCGACTTGGGATCGACAACTTTGAGTTCATCCGAGTGTTG
GGGAAGGGCAGCTTTGGGAAGGTGATGCTCGCAAGAATCAAGGAAACAGGAGACCTCTAT
GCTGTGAAGGTGCTGAAGAAGGACGTGATCCTGCAGGATGACGATGTGGAGTGCACCATG
ACCGAGAAAAGGATCCTGTCCCTGGCCCGCAGTCACCCCTTCCTCACGCAGCTCTTCTGC
TGCTTTCAGACCCCTGATCGTCTGTTTTTTGTGATGGAGTTTGTGAATGGGGGCGACTTG
ATGTTTCACATTCAGAAGTCCCGGCGTTTTGATGAAGCACGGGCTCGTTTCTATGCTGCA
GAGATCATTTCGGCACTTATGTTCCTACATGACAAAGGAATCATCTATAGAGATCTGAAA
CTGGACAATGTACTGTTGGACCACGAGGGCCACTGCAAACTGGCAGATTTCGGGATGTGC
AAGGAGGGGATCTGCAACGGGGTCACCACGGCCACCTTCTGCGGCACGCCCGACTACATT
GCTCCGGAGATCCTCCAGGAGATGCTCTACGGGCCCGCGGTGGACTGGTGGGCTATGGGC
GTGCTGCTCTACGAGATGCTGTGTGGCCACGCGCCCTTTGAGGCAGAAAACGAAGATGAC
CTCTTTGAGGCCATACTGAACGATGAAGTGGTCTACCCTACATGGCTGCATGAAGATGCC
ACAGGGATCCTGAAATCTTTCATGACCAAGAACCCCACCATGCGCTTGGGCAGCCCAAGT
CAAGGCGGTGAGCATGCCATCTTGAGACACCCTTTCTTTAAGGAAATCGACTGGGCCCAG
CTGAACCATCGCCAAGTAGAACCACCTTTCCGACCCAGAATCAAATCCCGAGAAGACGTC
AGTAATTTTGACCCCGACTTCATAAAGGAAGAACCGGTTTTAACTCCAATTGATGAGGGA
CATCTTCCTATGATCAACCAGGATGAGTTTAGAAACTTTTCCTTTGTCTCTCCAGAGTTG
CATCCATAG
|
| Protein Properties |
|---|
| Number of Residues
| 682 |
| Molecular Weight
| 77661.0 |
| Theoretical pI
| 7.8 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Protein kinase C, eta
MSSGTMKFNGYLRVRIGEAVGLQPTRWSLRHSLFKKGYQLLDPYLTVSVDQVVGQTRTKQ
KTNKPTYNEEFCANVTDGGHLELAVFHETPLGYDHFVANCTLQFQELLRTAGASDTFEGW
VDLEPEGKVFVVITLTGSFTEATLQRDRIFKHFTRKRQRAMRRRVHQINGHKFMATYLRQ
PTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNINKVDSKTAEQRFG
INIPHKFSVHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCGVNAVE
LAKTLAGMGLQPGNISPTSKLVSRSTLRRQGKESTKEGNGIGVNSSNRLGIDNFEFIRVL
GKGSFGKVMLARIKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARSHPFLTQLFC
CFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLK
LDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMG
VLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSPS
QGGEHAILRHPFFKEIDWAQLNHRQVEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEG
HLPMINQDEFRNFSFVSPELHP
|
| External Links |
|---|
| GenBank ID Protein
| AAI20028.1 |
| UniProtKB/Swiss-Prot ID
| Q0P5H4 |
| UniProtKB/Swiss-Prot Entry Name
| Q0P5H4_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC120027 |
| GeneCard ID
| PRKCH |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
