| Identification |
|---|
| BMDB Protein ID
| BMDBP01185 |
| Secondary Accession Numbers
| None |
| Name
| Serine/threonine-protein kinase N1 |
| Synonyms
|
Not Available
|
| Gene Name
| PKN1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| PKN1 |
| Gene Sequence
|
>2835 bp
ATGGCCAGCGACGCTGTGCAGAGTGAGCCGCGCAGCTGGTCCCTGCTGGAGCAGCTGGGC
CTGGCGGGTGCCGACCTGGCAGCCCCTGGGGTACAGCAGCAGCTGGAGCTGGAGCGGGAG
CGTCTGCGGCGGGAGATCCGCAAGGAGCTGAAGCTGAAAGAGGGTGCAGAGAACCTGCGG
CGAGCCACCACCGACCTGGGCCGTAACCTGGGCCCTGTGGAGCTGGTGCTGCGAGGCTCC
TCACGCAGGCTTGCCCTGCTGCACCAGCAGCTGCAGGAGCTGCATGCCCACGTGGTGCTG
CCCGACCCTGCGGTGGGCGTGCACGATGCCCCCCAGTCCCCTGGCACAGGCGACTCTGCC
TGCTCAGCCACCAACCTGAGCCGCGTGGCCGGTCTGGAGAAGCAGCTGGCCATCGAGCTG
AAGGTGAAGCAGGGGGCAGAGAACATGATCCAGACATACAGCAACGGCAGCACCAAGGAC
CGGAAGCTGCTGCTGACAGCCCAGCAGATGCTGCAAGACAGTAAGACCAAGATAGATATC
ATCCGCATGCAACTGCACCGGGCACTGCAGGCCTGCCAGCTGGAGAGCCAGGCGGCCCCA
GACGAGGCTCAAGGGAGTCCGGACTTGGGGGCAGTGGAGCTGCGCATCGAGGAGCTGCGT
CACCACTTCCGAGTGGAGCACGCGGTGGCCGAGGGCGCCAAGAATGTGCTGCGCCTGCTC
AGCGCCGCTAAGGCTCCGGACCGCAAAGCGGTCAGCGAGGCCCAGGAAAAGCTGACCGAG
TCCAACCAGAAGCTGGGGCTGCTTCGGGAGGCGCTGGAGCGGCGGCTTGGGGAGCTCCCT
GCTGACCACCCGAAGGGGCGGCTGCTGCGCGAAGAGCTCGCCGCGGCTTCGTCCGCAGCC
TTTAGCGCCCGCCTGGCCGGGCCGTTCCCCGCCACGCACTACAGCACCCTGAGCAAGCCT
GCACCACTCACAGGGACCCTGGAGGTGCGTGTGGTGGGCTGCAGAGACCTTCCAGAGACC
ATCCCTTGGAACCCTTCACCTTCGGTGGGGGGACCTGGGACCCCTGACAGCCGCACCCCC
TTCCTGAGCCGCCCAGCCCGAGGTCTTTACAGCCGAACCGGAAGTCTCAGTGGCAGGAGC
AGCCTCAAAGCGGAAGCTGAGAACACCAATGAGGTGAGCACTGTTCTCAAGCTGGATAAC
ACAGTGGTGGGACAGACATCCTGGAAGCCGTGTGGCCCCAACGCCTGGGACCAGAGCTTT
ACCCTGGAACTGGAGAGGGCACGGGAATTGGAGTTGGCTGTGTTCTGGCGGGACCAGCGG
GGCCTGTGTGCCCTCAAATTCCTGAAGTTGGAGGATTTCTTGGACAACGAGAGGCATGAG
GTGCAGCTGGACATGGAACCTCAGGGCTGCCTGGTGGCTGAGGTCACCTTCCGCAACCCT
GTCATTGAGAGGATCCCCCGGCTCCGACGACAGAAGAAGATCTTCTCCAAGCAGCAAGGG
AAGGCATTTCAGCGCGCTAGGCAGATGAACATCGACGTCGCCACCTGGGTACGGCTGCTC
CGCAGGCTCATCCCCAACGCCACAGCCACTGGTACCTTCAGCCCAGGGGCTTCACCAGGA
CCTGAGGCTCGGTCCACAGGTGACATATCTGTGGAGAAGCTGAACCTTGGGACTGAAACA
GACAGCTCACCCCAGAAGAGCCCTCTGGGTCCTCCTTCCAGCCCATCCAGTCTGAGTTCT
CCGATCCAGGCAACTACTACCACTCCCGAGCTGCCTTCGGAGACCCAGGAGACACCAGGC
CCCACGCTGTGCAGCCCTCTGAGGAAGTCACCCCTGACCCTCGAGGATTTCAAGTTCCTG
GCAGTGCTGGGCCGGGGTCACTTTGGGAAGGTGCTGCTCTCTGAATTCCGGCCCAGTGGG
GAGCTGTTCGCCATCAAGGCTTTGAAGAAAGGGGACATTGTGGCCCGAGACGAGGTGGAG
AGCCTGATGTGTGAGAAGCGGATCTTGGCAGCTGTGACCAATGCGGGACACCCCTTTCTG
GTGAACCTGTTTGGCTGTTTCCAGACACCAGAGCATGTATGCTTCGTGATGGAGTACTCA
GCTGGTGGGGACCTGATGCTGCACATCCACAGTGATGTGTTCTCGGAGCCCCGTGCTGTC
TTTTATTCGGCCTGTGTGGTGCTGGGGCTGCAGTTTCTCCACGAACACAAGATTGTCTAC
AGGGACCTGAAGTTGGACAATTTGCTTCTGGACACTGAGGGCTATGTCAAGATTGCAGAC
TTTGGCCTCTGCAAGGAGGGGATGGGCTATGGAGACCGGACCAGCACTTTCTGTGGGACC
CCAGAGTTCCTGGCACCTGAGGTGCTGACGGACACGTCGTACACTCGTGCGGTGGACTGG
TGGGGACTGGGCGTGTTGCTCTATGAAATGCTGGTTGGTGAGTCCCCATTCCCAGGGGAT
GATGAGGAGGAGGTATTTGACAGCATCGTCAACGATGAGGTTCGCTACCCCCGCTTCCTG
TCAGCTGAAGCCATTGGCATCATGCGCAGGCTCCTGCGGAGGAATCCAGAGCGGAGGTTG
GGATCCAGCGAGAGGGATGCTGAGGATGTGAAAAAACAGCCTTTCTTCAGGACCCTGGGC
TGGGATGCCCTGCTGGCCCGGCGCCTGCCGCCGCCTTTCGTACCCACGCTGGCCGGCCGC
ACTGATGTCAGCAACTTTGACGAGGAATTCACAGGGGAGGCCCCCACGCTGAGCCCACCC
CGCGACGCACGGCCCCTCACAGCCACCGAACAGGCGGCCTTCCGGGACTTCGACTTTGTG
GCTGGGAGCTGCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 944 |
| Molecular Weight
| 104133.0 |
| Theoretical pI
| 6.44 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Protein kinase N1
MASDAVQSEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLRREIRKELKLKEGAENLR
RATTDLGRNLGPVELVLRGSSRRLALLHQQLQELHAHVVLPDPAVGVHDAPQSPGTGDSA
CSATNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSKTKIDI
IRMQLHRALQACQLESQAAPDEAQGSPDLGAVELRIEELRHHFRVEHAVAEGAKNVLRLL
SAAKAPDRKAVSEAQEKLTESNQKLGLLREALERRLGELPADHPKGRLLREELAAASSAA
FSARLAGPFPATHYSTLSKPAPLTGTLEVRVVGCRDLPETIPWNPSPSVGGPGTPDSRTP
FLSRPARGLYSRTGSLSGRSSLKAEAENTNEVSTVLKLDNTVVGQTSWKPCGPNAWDQSF
TLELERARELELAVFWRDQRGLCALKFLKLEDFLDNERHEVQLDMEPQGCLVAEVTFRNP
VIERIPRLRRQKKIFSKQQGKAFQRARQMNIDVATWVRLLRRLIPNATATGTFSPGASPG
PEARSTGDISVEKLNLGTETDSSPQKSPLGPPSSPSSLSSPIQATTTTPELPSETQETPG
PTLCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVE
SLMCEKRILAAVTNAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAV
FYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGT
PEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFL
SAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWDALLARRLPPPFVPTLAGR
TDVSNFDEEFTGEAPTLSPPRDARPLTATEQAAFRDFDFVAGSC
|
| External Links |
|---|
| GenBank ID Protein
| AAI26540.1 |
| UniProtKB/Swiss-Prot ID
| A1A4I4 |
| UniProtKB/Swiss-Prot Entry Name
| PKN1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC126539 |
| GeneCard ID
| PKN1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
