| Identification |
|---|
| BMDB Protein ID
| BMDBP01235 |
| Secondary Accession Numbers
| None |
| Name
| Receptor-type tyrosine-protein phosphatase F |
| Synonyms
|
Not Available
|
| Gene Name
| PTPRF |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity (By similarity). |
| Pathways
|
- EPO Signaling Pathway
- FAS signaling pathway ( CD95 )
- Growth Hormone Signaling Pathway
- T Cell Receptor Signaling Pathway
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| PTPRF |
| Gene Sequence
|
>5697 bp
ATGACCCCTGAGCCAGCCCCAGGGAGGACGATGGTGCCCCTTGTCCCTGCACTTGTGATG
CTTGGTTTGGTGGCAGGTGCCCATGGCGACAGCAAACCTGTCTTTGTCAAGGTCCCCGAG
GACCAGACTGGATTGTCAGGAGGGGTGGCCTCCTTCGTGTGCCAAGCCACGGGGGAACCC
AAGCCGCGCATCACATGGATGAAGAAGGGGAAGAAAGTCAGCTCCCAGCGCTTCGAGGTC
ATCGAGTTTGATGACGGGGCAGGGTCTGTGCTGCGGATCCAGCCACTGCGGGTGCAGCGA
GACGAAGCCATCTATGAGTGCACGGCCACCAACAGTCTGGGGGAGATCAACACCAGTGCC
AAGCTCTCAGTGCTCGAAGAGGAACAGCTGCCCCTTGGGTTCCCCTCCATCGACATGGGG
CCTCAGCTGAAGGTGGTGGAGAAGGCCCGCACGGCCACTATGCTGTGTGCAGCAGGCGGG
AATCCAGACCCTGAGATCTCTTGGTTCAAGGACTTCCTCCCTGTGGACCCCGCCGCGAGC
AACGGCCGCATCAAGCAACTGCGTTCAGGTGCCTTGCAGATTGAGAGCAGCGAGGAGTCG
GACCAAGGCAAGTACGAGTGTGTGGCGACCAACTCTGCAGGCACTCGTTACTCGGCCCCT
GCCAACCTATATGTGCGAGTGCGCCGCGTGGCTCCGCGTTTCTCCATCCCTCCCAGCAGC
CAGGAGGTGATGCCGGGCGGCAGCGTGAACCTGACGTGCGTCGCCGTTGGCGCACCCATG
CCCTACGTGAAGTGGATGATGGGGGCCGAAGAGCTCACCAAGGAGGACGAGATGCCGGTC
GGCCGCAATGTGCTGGAGCTCAGCAACGTGGTGCGCTCCGCCAACTACACTTGCGTGGCC
ATCTCCTCCCTGGGCATGATCGAGGCCACGGCCCAGGTCACCGTGAAAGCCCTGCCGAAG
CCTCCAATTGACCTTGTGGTGACAGAGACAACTGCCACCAGCGTCACTCTGACCTGGGAC
TCTGGGAACTCAGAGCCTGTATCCTACTATGGCATCCAGTACCGCCCAGCGGGCGCGGAG
GGCCCCTTCCAGGAGGTGGACGGCGTGGCCACCACCCGCTACAGCATCGGCGGCCTGAGC
CCTTTCTCAGAGTACGCCTTCCGCGTGCTGGCGGTGAACAGCATCGGGCGCGGGCCGCCC
AGCGAGGCGGTGCGGGCGCGCACGGGGGAGCAGGCGCCCTCCAGCCCCCCGCGCCGCGTG
CAGGCACGCATGCTAAGCGCCAGCACCATGCTGGTGCAGTGGGAGCCGCCCGAGGAGCCT
AACGGCCTGGTGCGGGGCTACCGCGTCTACTACACCCCCGACTCCCGCCGCCCTCTGAGC
GCCTGGCACAAGCACAACACAGACGCCGGGCTCCTCACCACTGTGGGCAGCCTGCTGCCT
GGCATCACCTACAGCCTGCGTGTGCTGGCCTTCACCGCCGTGGGCGACGGCCCCCCCAGC
CCCACCATCCAGGTCAAGACGCAGCAGGGAGTGCCTGCCCAGCCCGCGGACTTCCAGGCC
GAGGTGGACTCAGACACCAGGATCCAGCTCTCGTGGCTGCTGCCCCCGCAGGAGCGGATC
GTCAAGTATGAGCTGGTGTACTGGGCGGCAGAGGACGAGGGCCAGCAGCACAAGGTGACC
TTCGACCCCACGTCCTCCTATACCGTAGAGGACCTGAAGCCCGACACACTGTACCGCTTC
CAGCTGGCCGCCCGCTCTGAGCTGGGGGTGGGAGTCTTCACCCCCACCATTGAGGCTCGC
ACAGCACAGTCCACCCCCTCCGCACCCCCCCAGAAGGTGACGTGTGTGAGCGTGGGCTCC
ACCACCGTCCGGGTAAGTTGGGTCCCGCCGCCGGCCGACAGCCGCAACGGCGTCATCACC
CAGTACTCGGTGGCCTACGAGGCGGTGGACGGCGAGGACCGTGGGCGGCACGTGGTGGAC
GGCATCGGCCGCGAGCACTCCAGCTGGGACCTGGTGGGCCTGGAGAAGTGGACGGAGTAC
CGGGTGTGGGTGCGGGCGCACACGGACGTGGGCCCCGGCCCCGAGAGCAGCCCGGTGCTG
GTCCGCACCGACGAGGACGTGCCCAGTGGGCCACCGCGGAAGGTGGAGGTGGAGCCGCTC
AACTCCACTGCCGTGCGCGTCTCCTGGAAGCTGCCCGTCCCCAGCAAGCAGCATGGCCAG
ATCCGCGGCTACCAGGTCACCTACGTGCGGCTGGAGAATGGCGAGCCCCGCGGCGCCCCC
ATCATCCAGGACGTCATGCTGGCCGAGGCCCAGGAAACCACCATCAGCGGCCTGACCCCG
GAGACCACCTACTCCATCACCGTGGCTGCCTACACCACCAAGGGGGACGGTGCCCGCAGC
AAGCCCAAAATTGTCACGACCACAGGGGCAGTCCCAGGACGGCCCACCATGATGGTCAGC
ACCACGGCCATGAACACGGCGCTGCTCCAGTGGCACCCGCCCAAGGAGCTGCCCGGGGAG
CTCCTGGGCTACCGGCTGCAGTACCGCCGAGCCGACGAGGCGCGGCCCAGCACCATCGAT
TTTGGCAAGGACGACCAGCACTTTACGGTCACTGGCCTGCACAAAGGGGCCACCTACATC
TTCCGGCTCACTGCCAAGAACCGGGCCGGCCTGGGCGAGGAGTTCGAGAAGGAAATCACG
ACCCCCGAGGACGTGCCCAGCGGTTTCCCCCAAAACCTGCGCGTGATAGGGCTGACCACA
TCTACCACGGAACTGATCTGGGACCCCCCAGTGCTGGCGGAGAGGAACGGGCGCATCACC
AACTACACCGTGGTGTACCGTGACATCAACAGCCAGCAGGAGCTTCAGAACGTCACTGCC
GACACCCACCTGACGCTCTCCGGCCTCAAGCCAGACACCACTTACGACATCAAGGTCCGC
GCACGCACCAGCAAGGGCGCCGGCCCGCTCAGCCCCAGCATCCAGTCCCGGACCATGCCC
GTGGAGCAAGTGTTTGCCAAGAACTTCCGTGTGGAGGCTGCAATGAAGACATCTGTGCTG
CTCAGCTGGGAGGTGCCCGACTCCTACAAGTCAGCAGTGCCCTTCAGGATCCTGTACAAT
GGGCAGAGCGTGGAGGTGGACGGGCACTCCATGCGGAAGCTGATTGCAGACCTGCAGCCC
AACACTGAATACTCATTTGTGCTGATGAACCGCGGCAGCAGCGCGGGGGGCCTGCAACAC
CTCGTGTCCATCCGCACGGCCCCCGACCTCCTGCCGCACAAGCCACTGCCAGCCTCGGCC
TACATCGAGGACGGCCGCTTCACCCTCACCATGCCCCGCGTGCAGGAACCCGCACTGGTC
AGGTGGTTCTACATCATGGTGGTGCCCATTGACCGCATGGGAGGGAGCATGCTGGCGCCA
CAGTGGAGCACGCCCGAGGAGCTGGAGCTGGACGAGCTGCTGGAGGCCATCGAGCAGGGC
GGCGGGGAGCGGCTGCGGCGCCGGCGGCAGACGGAGCGGCTGAAGCCATACGTGGCCGCT
CAGGTGGACGTTCTCCCGGAGACCTTCACCTTGGGGGACAAGAAGAACTATCAAGGCTTC
TACAACCGGCCGCTGTCTCCAGACCTGAGCTACCAGTGCTTTGTGCTCGCCTCCCTGAAG
GAACCCGTGGACCAGAAGCGCTATGCCTGCAGCCCCTACTCCGATGAGATCGTGGTCCAG
GTGACACCAGCCCAGCAGCAGGAGGAACCCGAGCTGCTGTGGGTGACGGGCCCCGTCCTG
GCAGTCATTCTCATCGTCCTCATTGTCATCGCCATTCTCCTGTTCAAGAGGAAAAGGACC
CACTCCCCATCGTCCAAGGATGAGCAGTCAATTGGGCTGAAGGACTCCTTGCTGGCCCAC
TCCTCCGACCCTGTGGAGATGCGGCGGCTCAACTACCAGACCCCAGGTATGCGAGACCAC
CCGCCCATCCCCATCACCGACCTAGCTGACAACATCGAGCGCCTCAAAGCCAATGACGGC
CTCAAGTTCTCCCAGGAGTACGAGTCAATTGACCCAGGACAGCAGTTCACGTGGGAGAAT
TCAAACCTGGAGGTGAACAAGCCGAAGAACCGCTATGCCAACGTCATTGCTTACGACCAC
TCTCGAGTCATCCTTACCTCCATCGATGGTGTCCCCGGGAGCGACTACATCAATGCCAAT
TACATCGACGGCTACCGCAAGCAGAACGCCTACATTGCCACGCAGGGCCCGCTGCCTGAG
ACCATGGGCGATTTCTGGCGGATGGTGTGGGAACAGCGCACAGCCACTGTGGTCATGATG
ACGCGGCTGGAGGAGAAGTCCCGGGTGAAATGTGACCAGTACTGGCCAGCTCGTGGCACC
GAGACCTATGGCCTCATCCAGGTGACCCTGCTGGACACGGTGGAGCTGGCCACCTACACT
GTGCGCACCTTCGCGCTCTACAAGAGTGGCTCCAGTGAGAAGCGGGAGCTGCGTCAGTTC
CAGTTCATGGCCTGGCCAGACCACGGAGTCCCCGAGTACCCGACCCCTATCCTGGCCTTC
CTGCGGCGGGTCAAGGCTTGCAACCCCCTGGACGCGGGGCCCATGGTGGTGCACTGCAGC
GCGGGCGTGGGCCGCACGGGCTGCTTCATCGTCATCGACGCCATGCTGGAGCGGATGAAG
CACGAGAAGACAGTGGACATCTACGGCCACGTGACGTGCATGCGGGCGCAGCGCAACTAC
ATGGTGCAGACTGAGGACCAGTACGTGTTCATCCACGAGGCGCTGCTGGAGGCCGCCATG
TGTGGACACACGGAGGTGCCCGCCCGCAACCTCTACGCCCACATCCAGAAGCTGGGCCAA
GTGCCTCCCGGGGAGAGTGTGACTGCCATGGAGCTGGAGTTCAAGTTGCTGGCCAACTCC
AAGGCCCACACATCCCGCTTCATCAGCGCCAACCTGCCCTGCAACAAGTTCAAGAACCGC
CTGGTGAACATCATGCCCTACGAACTGACCCGTGTGTGTCTGCAGCCCATCCGCGGCGTG
GAGGGCTCCGACTACATCAATGCCAGCTTCCTGGATGGCTATCGACAGCAGAAGGCCTAC
ATAGCCACACAGGGGCCTCTGGCGGAGAGCACCGAGGATTTCTGGCGCATGTTATGGGAG
CACAACTCCACCATCATCGTCATGCTGACCAGGCTTCGGGAGATGGGCCGGGAGAAATGC
CACCAGTACTGGCCTGCAGAGCGCTCTGCTCGCTACCAGTACTTTGTCGTCGACCCGATG
GCTGAGTACAACATGCCCCAGTATATTCTCCGTGAGTTCAAGGTCACGGATGCCCGGGAT
GGGCAGTCGAGGACAATCCGGCAGTTCCAGTTCACAGACTGGCCGGAGCAGGGCGTGCCT
AAAACGGGCGAGGGCTTCATCGACTTCATCGGGCAGGTGCACAAGACCAAGGAGCAGTTC
GGGCAGGACGGGCCCATCACGGTGCACTGCAGTGCTGGTGTGGGCCGCACTGGGGTGTTC
ATCACGCTGAGCATTGTCCTGGAGCGGATGCGCTACGAAGGCGTGGTTGACATGTTCCAG
ACCGTGAAGACCCTGCGCACACAGCGCCCAGCCATGGTGCAGACGGAGGACCAGTATCAG
CTGTGCTACCGCGCGGCCCTGGAGTACCTCGGAAGCTTTGACCACTATGCAACGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 1898 |
| Molecular Weight
| 211382.0 |
| Theoretical pI
| 6.48 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Receptor-type tyrosine-protein phosphatase F
MTPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFVKVPEDQTGLSGGVASFVCQATGEP
KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA
KLSVLEEEQLPLGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPAAS
NGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSS
QEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVA
ISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVSYYGIQYRPAGAE
GPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRV
QARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPLSAWHKHNTDAGLLTTVGSLLP
GITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVDSDTRIQLSWLLPPQERI
VKYELVYWAAEDEGQQHKVTFDPTSSYTVEDLKPDTLYRFQLAARSELGVGVFTPTIEAR
TAQSTPSAPPQKVTCVSVGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVD
GIGREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPL
NSTAVRVSWKLPVPSKQHGQIRGYQVTYVRLENGEPRGAPIIQDVMLAEAQETTISGLTP
ETTYSITVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMVSTTAMNTALLQWHPPKELPGE
LLGYRLQYRRADEARPSTIDFGKDDQHFTVTGLHKGATYIFRLTAKNRAGLGEEFEKEIT
TPEDVPSGFPQNLRVIGLTTSTTELIWDPPVLAERNGRITNYTVVYRDINSQQELQNVTA
DTHLTLSGLKPDTTYDIKVRARTSKGAGPLSPSIQSRTMPVEQVFAKNFRVEAAMKTSVL
LSWEVPDSYKSAVPFRILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQH
LVSIRTAPDLLPHKPLPASAYIEDGRFTLTMPRVQEPALVRWFYIMVVPIDRMGGSMLAP
QWSTPEELELDELLEAIEQGGGERLRRRRQTERLKPYVAAQVDVLPETFTLGDKKNYQGF
YNRPLSPDLSYQCFVLASLKEPVDQKRYACSPYSDEIVVQVTPAQQQEEPELLWVTGPVL
AVILIVLIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDH
PPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDH
SRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMM
TRLEEKSRVKCDQYWPARGTETYGLIQVTLLDTVELATYTVRTFALYKSGSSEKRELRQF
QFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMK
HEKTVDIYGHVTCMRAQRNYMVQTEDQYVFIHEALLEAAMCGHTEVPARNLYAHIQKLGQ
VPPGESVTAMELEFKLLANSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGV
EGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTRLREMGREKC
HQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVP
KTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQ
TVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT
|
| External Links |
|---|
| GenBank ID Protein
| AAI51593.1 |
| UniProtKB/Swiss-Prot ID
| A7MBJ4 |
| UniProtKB/Swiss-Prot Entry Name
| PTPRF_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC151592 |
| GeneCard ID
| PTPRF |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
