| Identification |
|---|
| BMDB Protein ID
| BMDBP01245 |
| Secondary Accession Numbers
| None |
| Name
| 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase |
| Synonyms
|
Not Available
|
| Gene Name
| ADI1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in nickel ion binding |
| Specific Function
| Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. |
| Pathways
|
- Amino-acid biosynthesis
- L-methionine biosynthesis via salvage pathway
- L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| Not Available |
| SNPs
| ADI1 |
| Gene Sequence
|
>540 bp
ATGGTGGAGGCCTGGTACATAGACGATGCGGCCGACGACCCGCGGCTGCCGCACCGCGCC
GAGCCCGCGCGCCCTGTCGGCCTGGAGCAGCTGCGCCGGCTCGGGGTCCTTTACTGGAAG
CTGGATGCAGACAAATACGAGAACGATCCAGAATTAGAGAAGATCCGCAAAGAGAGAAAC
TACTCCTGGGTGGACATCATAACCATAAGCAAAGACAAACTACCGAATTACGAGGAAAAG
ATCAAGATGTTCTTTGAGGAGCACTTACACCTGGACGAGGAGATCCGCTACATCCTGGAC
GGCAGCGGGTACTTTGACGTGCGGGACCAGGAGGACCGCTGGATCCGGATCTCCATGGAG
AAGGGGGACATGATCACCCTGCCCGCCGGCATCTACCACCGCTTCACGCTGGACGAGAAG
AACTACGTGAAGGCCATGCGGCTGTTCGTGGGAGACCCCGTGTGGACGCCATACAACCGG
CCGTCGGACCACCTCGAGGCCCGGACGCAATACCTGGAGTTCCTGGCGCAGTCGGCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 179 |
| Molecular Weight
| 21487.0 |
| Theoretical pI
| 4.8 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
MVEAWYIDDAADDPRLPHRAEPARPVGLEQLRRLGVLYWKLDADKYENDPELEKIRKERN
YSWVDIITISKDKLPNYEEKIKMFFEEHLHLDEEIRYILDGSGYFDVRDQEDRWIRISME
KGDMITLPAGIYHRFTLDEKNYVKAMRLFVGDPVWTPYNRPSDHLEARTQYLEFLAQSA
|
| External Links |
|---|
| GenBank ID Protein
| AAI03236.1 |
| UniProtKB/Swiss-Prot ID
| Q3ZBL1 |
| UniProtKB/Swiss-Prot Entry Name
| MTND_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AAFC03041642 |
| GeneCard ID
| ADI1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
